Widespread expression of functional D1-dopamine receptors in fetal rat brain
Abstract
Maternal treatment with cocaine or the D1-dopamine receptor agonist, SKF 38393, induces expression of the immediate-early gene, c-fos, in fetal rodent brain. Our previous studies have focused on the suprachiasmatic nucleus late in gestation. In the present report, we examined the anatomical distribution of functional D1-dopamine receptors throughout fetal rat brain. Functional D1 receptors were defined using three complementary methods: in situ hybridization to detect D1 receptor mRNA, autoradiographic detection of 125I-SCH 23982 binding, and in situ hybridization to detect c-fos gene expression induced by maternal treatment with SKF 38393. D1-dopamine receptor binding, receptor mRNA, and SKF 38393-induced c-fos gene expression are widespread in fetal brain by late gestation. These data indicate that the fetal brain is sensitive to dopamine receptor activation, and suggest that gestational exposure to drugs of abuse acting via dopaminergic mechanisms may influence fetal brain function.
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SKF 38,393 is a D1-receptor agonist that induces c-Fos protein in several brain areas, including the amygdala and BST, within an hour following a systemic infusion.
“SKF 38,393 is a D1-receptor agonist that induces c-Fos protein in several brain areas, 54,55 including the amygdala and BST, 34 within an hour following a systemic infusion”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [55]
In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus.
“In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN26–28, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus29,30.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [29]
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- Authors
- Shearman, L. P., Zeitzer, J., & Weaver, D. R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Weaver, David R
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 102
- Issue
- 1
- Pages
- 105-115
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2045073877
- Cited by
- 35
- References
- 33
- Citations by year
- 2022: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2012: 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd029470-03)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-14427, HD29470)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D1 receptor, fetal brain, dopamine receptor expression, c-fos, SKF 38393, cocaine, prenatal drug exposure, dopaminergic signaling, receptor mRNA, receptor binding, rats
- MeSH terms
- Animals, Autoradiography, Brain, Corpus Striatum, Embryonic and Fetal Development, Radioligand Assay, RNA, Messenger, Pharmaceutical Vehicles, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Dopamine D1, Gene Expression Regulation, Developmental, Rats
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