Cited by 222Neuroinflammation and Neurodegeneration MechanismsChemokine receptors and signalingAcute Ischemic Stroke Management

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury

Soriano, Sulpicio G., Amaravadi, Lakshmi S., Wang, Yanming F., Zhou, Hong, Yu, Gary X., Tonra, James R., Fairchild-Huntress, Victoria, Fang, Qing, Dunmore, Judy H., Huszar, Dennis, Pan, Yang·2002·Journal of Neuroimmunology

DOI 10.1016/s0165-5728(02)00033-4

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Abstract

Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound forms and is upregulated during brain inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its receptor CX(3)CR1 on leukocytes and microglia. We generated FKN-deficient mice to study the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-deficient mice had a 28% reduction in infarction size and lower mortality rate, when compared to wild-type littermates. The findings of this study indicate a possible role for FKN in augmenting postischemic injury and mortality after transient focal cerebral ischemia.

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Retracted
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Authors: Soriano, S. G., Amaravadi, L. S., Wang, Y. F., Zhou, H., Yu, G. X., Tonra, J. R., Fairchild-Huntress, V., Fang, Q., Dunmore, J. H., Huszar, D., & Pan, Y.
Affiliations: Boston Children's Hospital (US)
Takeda Oncology (United States) (US)
Corresponding author: Soriano, Sulpicio G.
ORCID: Soriano, Sulpicio G.
Amaravadi, Lakshmi S.
Zhou, Hong
Tonra, James R.
Huszar, Dennis
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2002-04
Volume: 125
Issue: 1-2
Pages: 59-65
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(02)00033-4
OpenAlex: W2077196241
Cited by: 222
References: 20
Citations by year: 2026: 4 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 11 · 2015: 15 · 2014: 15 · 2013: 13 · 2012: 10
FWCI: 5.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: fractalkine, CX3C chemokines, CX3CR1, transient focal cerebral ischemia, ischemia-reperfusion injury, infarct size, neuroprotection, chemokine receptors, neuroinflammation, microglia
MeSH terms: Animals, Ischemic Attack, Transient, Disease Susceptibility, Membrane Proteins, Mice, Inbred BALB C, RNA, Messenger, Reperfusion Injury, Gene Expression, Mice, Knockout, Infarction, Middle Cerebral Artery, Chemokines, CX3C, Mice, Chemokine CX3CL1

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Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury

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