The EAE-associated behavioral syndrome I. Temporal correlation with inflammatory mediators
Abstract
To elucidate the mechanisms underlying the EAE-associated behavioral syndrome (EBS), we examined the temporal correlation between the behavioral alterations and inflammatory processes. Onset of the behavioral syndrome was associated with the onset of brain infiltration, as well as mRNA expression of interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) and elevated production of interleukin 1 beta protein and prostaglandin E(2) (PGE(2)). Sickness behavior symptoms coincided with peak cytokine expression. Behavioral recovery was associated with a reduction of cytokine expression, but not infiltration, PGE(2) production or motor disturbances. These results suggest that inflammatory processes in general, and the production of pro-inflammatory cytokines in particular, are involved in mediating EAE-associated sickness behavior.
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Multiple sclerosis can be modelled in rodents by experimental allergic encephalomyelitis (EAE), which is associated with clear signs of sickness and depression-like behaviour.
“This autoimmune neuroinflammatory disease can be modelled in rodents by a condition known as experimental allergic encephalomyelitis (EAE) that is associated with clear signs of sickness and depression-like behaviour88,89.”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [88]
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Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130 · see citing works
Cytokines, “depression due to a general medical condition”, and antidepressant drugs
Yirmiya, R., Weidenfeld, J., Pollak, Y., Morag, M., Morag, A., Avitsur, R., Barak, O., Reichenberg, A., Cohen, E., Shavit, Y., et al. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_16 · Cited by 208 · see citing works
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From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125 · see citing works
- Authors
- Pollak, Y.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Pollak, Y
- ORCID
- Pollak, Y
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 137
- Issue
- 1-2
- Pages
- 94-99
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1978292506
- Cited by
- 55
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 5 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- experimental autoimmune encephalomyelitis, sickness behavior, inflammatory cytokines, IL-1β, TNF-α, prostaglandin E2, brain infiltration, behavioral recovery, motor disturbances
- MeSH terms
- Animals, Behavior, Animal, Brain, Encephalomyelitis, Autoimmune, Experimental, Female, Gene Expression Regulation, Interleukin-1, RNA, Messenger, Dinoprostone, Cytokines, Mice
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