Mapping inflammation onto mood: inflammatory mediators of anhedonia
Abstract
Evidence supports inflammatory involvement in mood and cognitive symptoms across psychiatric, neurological and medical disorders; however, inflammation is not a sensitive or specific characteristic of these diagnoses. The National Institute of Mental Health Research Domain Criteria (RDoC) ask for a shift away from symptom-based diagnoses toward a transdiagnostic neurobiological focus in the study of brain illnesses. The RDoC matrix may provide a useful framework for integrating the effects of inflammation on brain function. Based on preclinical and clinical findings, relevant relationships span negative and positive valence systems, cognitive systems, systems for social processes and arousal/regulatory systems. As an exemplar, we consider the psychopathological domain of anhedonia, conceptualizing the relevance of inflammation (e.g., cellular immunity) and downstream processes (e.g., indoleamine 2,3-dioxygenase activation and oxidative inactivation of tetrahydrobiopterin) across RDoC units of analysis (e.g., catecholamine neurotransmitter molecules, nucleus accumbens medium spiny neuronal cells, dopaminergic mesolimbic and mesocortical reward circuits, animal paradigms, etc.). We discuss implications across illnesses affecting the brain, including infection, major depressive disorder, stroke, Alzheimer's disease and type 2 diabetes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Much of the induced inflammation work has found reduced reward-related neural activity after an inflammatory stimulus, generally consistent with preclinical research.
“Much of this work has shown attenuated reward-related neural activity following an inflammatory stimulus, which is generally consistent with preclinical research on inflammation and reward (See Swardfager et al., 2016 for review).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Swardfager et al., 2016
Cites
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Self-citationInflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
Inflammation in Atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.009 · Cited by 2,228 · see citing works
Biological basis of the behavior of sick animals
Hart, B. L. (1988) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(88)80004-6 · Cited by 2,223 · see citing works
Genome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778 · see citing works
Lenggenhager, J. (1947) · PubMed · Cited by 1,772 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Normalization of obesity-associated insulin resistance through immunotherapy
Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works
Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
Barth, J., Schumacher, M., & Herrmann-Lingen, C. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146332.53619.b2 · Cited by 1,358 · see citing works
De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works
Inflammation and insulin resistance
de Luca, C., & Olefsky, J. M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.057 · Cited by 1,161 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
A Meta-Analysis of Cytokines in Alzheimer's Disease
Swardfager, W., Lanctôt, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.012 · Cited by 1,108 · see citing works
Self-citationTyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069 · see citing works
Time-related predictors of suicide in major affective disorder
FAWCETT, J. A., Scheftner, W. A., Fogg, L., Clark, D. C., Young, M. A., Hedeker, D., & Gibbons, R. D. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.9.1189 · Cited by 1,058 · see citing works
Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2353 · Cited by 1,050 · see citing works
Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works
Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90746-3 · Cited by 986 · see citing works
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
Setiawan, E., Wilson, A. A., Mizrahi, R., Rusjan, P. M., Miler, L., Rajkowska, G., Suridjan, I., Kennedy, J. L., Rekkas, P. V., Houle, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2427 · Cited by 939 · see citing works
The vascular depression hypothesis: mechanisms linking vascular disease with depression
Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works
Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Neuroinflammation in Parkinson's disease and its potential as therapeutic target
Wang, Q., Liu, Y., & Zhou, J. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0042-0 · Cited by 884 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Hilmas, C., Pereira, E., Alkondon, M., Rassoulpour, A., Schwarcz, R., & Albuquerque, E. X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07463.2001 · Cited by 772 · see citing works
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.015 · Cited by 756 · see citing works
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works
Reward processing dysfunction in major depression, bipolar disorder and schizophrenia
Whitton, A. E., Treadway, M. T., & Pizzagalli, D. A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000122 · Cited by 740 · see citing works
Neopterin as a Marker for Immune System Activation
Murr, C., Widner, B., Wirleitner, B., & Fuchs, D. (2002) · Current Drug Metabolism · doi:10.2174/1389200024605082 · Cited by 737 · see citing works
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · see citing works
Lamers, F., Vogelzangs, N., Merikangas, K. R., de Jonge, P., Beekman, A. T. F., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.144 · Cited by 691 · see citing works
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works
Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 647 · see citing works
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620 · see citing works
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Self-citationInflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596 · see citing works
Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.007 · Cited by 596 · see citing works
Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders: A Nationwide Study
Benros, M. E., Waltoft, B. L., Nordentoft, M., Østergaard, S. D., Eaton, W. W., Krogh, J., & Mortensen, P. B. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1111 · Cited by 572 · see citing works
Stress, depression, and anhedonia: caveats concerning animal models
Anisman, H., & Matheson, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.007 · Cited by 569 · see citing works
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
Dopamine Signaling in reward-related behaviors
Baik, J. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00152 · Cited by 534 · see citing works
The blood-brain barrier and immune function and dysfunction
Banks, W. A., & Erickson, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.031 · Cited by 523 · see citing works
Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 510 · see citing works
Self-citationO’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works
Barefoot, J. C., Helms, M. J., Mark, D. B., Blumenthal, J. A., Califf, R. M., Haney, T. L., O’Connor, C. M., Siegler, I. C., & Williams, R. B. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00380-3 · Cited by 492 · see citing works
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Kleinridders, A., Cai, W., Cappellucci, L., Ghazarian, A., Collins, W. R., Vienberg, S. G., Pothos, E. N., & Kahn, C. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500877112 · Cited by 486 · see citing works
Neurons in the frontal lobe encode the value of multiple decision variables
Kennerley, S. W., Dahmubed, A. F., Lara, A. H., & Wallis, J. D. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21100 · Cited by 453 · see citing works
Grosso, G., Pajak, A., Marventano, S., Castellano, S., Galvano, F., Bucolo, C., Drago, F., & Caraci, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096905 · Cited by 449 · see citing works
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.011 · Cited by 448 · see citing works
Leptin: A potential novel antidepressant
Lu, X.-Y., Kim, C. S., Frazer, A., & Zhang, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508901103 · Cited by 446 · see citing works
Frenois, F., Moreau, M., O’Connor, J., Lawson, M., Micon, C., Lestage, J., Kelley, K. W., Dantzer, R., & Castanon, N. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.005 · Cited by 438 · see citing works
Salamone, J. D., Correa, M., Mingote, S., & Weber, S. M. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035063 · Cited by 433 · see citing works
Uher, R., Perlis, R. H., Henigsberg, N., Zobel, A., Rietschel, M., Mors, O., Hauser, J., Dernovsek, M. Z., Souery, D., Bajs, M., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291711001905 · Cited by 420 · see citing works
Obesity, Inflammation, and Cardiovascular Risk
Mathieu, P., Lemieux, I., & Després, J. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.311 · Cited by 416 · see citing works
Akhondzadeh, S., Jafari, S., Raisi, F., Nasehi, A. A., Ghoreishi, A., Salehi, B., Mohebbi-Rasa, S., Raznahan, M., & Kamalipour, A. (2009) · Depression and Anxiety · doi:10.1002/da.20589 · Cited by 397 · see citing works
Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 394 · see citing works
Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
Berk, M., Dean, O. M., Drexhage, H. A., McNeil, J. J., Moylan, S., O'Neil, A. E., Davey, C. G., Sanna, L., & Maes, M. H. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-74 · Cited by 392 · see citing works
Dilger, R. N., & Johnson, R. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208108 · Cited by 391 · see citing works
Capuron, L., Pagnoni, G., Drake, D. F., Woolwine, B. J., Spivey, J. R., Crowe, R. J., Votaw, J. R., Goodman, M. M., & Miller, A. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2094 · Cited by 382 · see citing works
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · see citing works
Goldberg, J. F., Burdick, K. E., & Endick, C. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.564 · Cited by 372 · see citing works
Capuron, L., Schroecksnadel, S., Féart, C., Aubert, A., Higueret, D., Barberger-Gateau, P., Layé, S., & Fuchs, D. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.006 · Cited by 368 · see citing works
Nutt, D., Demyttenaere, K., Janka, Z., Aarre, T., Bourin, M., Canonico, P. L., Carrasco, J. L., & Stahl, S. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106069938 · Cited by 366 · see citing works
Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
Zarate, C. A., Payne, J. L., Singh, J. B., Quiroz, J. A., Luckenbaugh, D. A., Denicoff, K. D., Charney, D. S., & Manji, H. K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.013 · Cited by 347 · see citing works
Abbasi, S.-H., Hosseini, F., Modabbernia, A., Ashrafi, M., & Akhondzadeh, S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.033 · Cited by 344 · see citing works
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression.
Kim, H., Chen, L. L., Lim, G., Sung, B., Wang, S.-X., McCabe, M. F., Rusanescu, G., Yang, L.-L., Tian, Y.-H., & Mao, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61884 · Cited by 310 · see citing works
An inflammatory review of Parkinson's disease
Orr, C. F., Rowe, D. B., & Halliday, G. M. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00127-2 · Cited by 309 · see citing works
O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works
D, M. F. M., & Mischoulon, D. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.8157su1c.03 · Cited by 301 · see citing works
Nery, F. G., Monkul, E. S., Hatch, J. P., Fonseca, M., Zunta‐Soares, G. B., Frey, B. N., Bowden, C. L., & Soares, J. C. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.912 · Cited by 298 · see citing works
Neurobiological mechanisms of anhedonia
Gorwood, P. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.3/pgorwood · Cited by 285 · see citing works
Papakostas, G. I., Shelton, R. C., Zajecka, J. M., Etemad, B., Rickels, K., Clain, A., Baer, L., Dalton, E. D., Sacco, G. R., Schoenfeld, D., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11071114 · Cited by 275 · see citing works
Chronic Immune Stimulation Correlates with Reduced Phenylalanine Turnover
Neurauter, G., Schrocksnadel, K., Scholl-Burgi, S., Sperner-Unterweger, B., Schubert, C., Ledochowski, M., & Fuchs, D. (2008) · Current Drug Metabolism · doi:10.2174/138920008785821738 · Cited by 274 · see citing works
Savitz, J., Drevets, W. C., Smith, C. M., Victor, T. A., Wurfel, B. E., Bellgowan, P. S., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.194 · Cited by 272 · see citing works
Lally, N., Nugent, A. C., Luckenbaugh, D. A., Ameli, R., Roiser, J. P., & Zarate, C. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.105 · Cited by 271 · see citing works
Inflammation, Depressive Symptomatology, and Coronary Artery Disease
Appels, A., Bär, F. W. H. M., Bär, J., Bruggeman, C., & de Baets, A. M. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200009000-00001 · Cited by 270 · see citing works
Salazar, A., Gonzalez-Rivera, B. L., Redus, L., Parrott, J. M., & O’Connor, J. C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.03.010 · Cited by 261 · see citing works
Lapteva, L., Nowak, M., Yarboro, C. H., Takada, K., Roebuck‐Spencer, T., Weickert, T. W., Bleiberg, J., Rosenstein, D. L., Pao, M., Patronas, N. J., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22031 · Cited by 259 · see citing works
Molecular basis of homocysteine toxicity in humans
Jakubowski, H. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3204-7 · Cited by 257 · see citing works
The role of dopamine in reward and pleasure behaviour – review of data from preclinical research
Bressan, R. A., & Crippa, J. A. S. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00540.x · Cited by 254 · see citing works
Spijker, J., Bijl, R. V., De Graaf, R., & Nolen, W. A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.103002122.x · Cited by 254 · see citing works
PERSOONS, P., VERMEIRE, S., DEMYTTENAERE, K., FISCHLER, B., VANDENBERGHE, J., VAN OUDENHOVE, L., PIERIK, M., HLAVATY, T., VAN ASSCHE, G., NOMAN, M., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02535.x · Cited by 253 · see citing works
Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity
Gilbody, S. M., Lightfoot, T., & Sheldon, T. (2007) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.050385 · Cited by 251 · see citing works
Molecular Basis of Sickness Behavior<sup>a</sup>
DANTZER, R., BLUTHÉ, R., GHEUSI, G., CREMONA, S., LAYÉ, S., PARNET, P., & KELLEY, K. W. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb08321.x · Cited by 249 · see citing works
Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity
Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., & Nakao, K. (2011) · Endocrinology · doi:10.1210/en.2011-0004 · Cited by 247 · see citing works
Zinc in depression: a meta-analysis
Swardfager, W., Herrmann, N., Mazereeuw, G., Goldberger, K., Harimoto, T., & Lanctôt, K. L. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.008 · Cited by 246 · see citing works
Self-citationThomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 235 · see citing works
Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies
Rotella, F., & Mannucci, E. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.11.022 · Cited by 230 · see citing works
Integrated Neurobiology of Bipolar Disorder
Maletic, V., & Raison, C. L. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00098 · Cited by 227 · see citing works
Gibney, S. M., McGuinness, B. W., Prendergast, C., Harkin, A., & Connor, T. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.11.010 · Cited by 220 · see citing works
Langley, R. G. B., Feldman, S. R., Han, C., Schenkel, B., Szapary, P. O., Hsu, M.-C., Ortonne, J. P., Gordon, K. B., & Kimball, A. B. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.09.014 · Cited by 218 · see citing works
Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study
Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.001 · Cited by 216 · see citing works
Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00166-9 · Cited by 214 · see citing works
Felger, J. C., Mun, J., Kimmel, H. L., Nye, J. A., Drake, D. F., Hernandez, C. R., Freeman, A. A., Rye, D. B., Goodman, M. M., Howell, L. L., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.115 · Cited by 214 · see citing works
Felger, J. C., Alagbe, O., Hu, F., Mook, D., Freeman, A. A., Sanchez, M. M., Kalin, N. H., Ratti, E., Nemeroff, C. B., & Miller, A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.026 · Cited by 214 · see citing works
Hannestad, J. O., Gallezot, J., Schafbauer, T., Lim, K., Kloczynski, T., Morris, E. D., Carson, R. E., Ding, Y., & Cosgrove, K. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.055 · Cited by 213 · see citing works
Garfield, J. B. B., Lubman, D. I., & Yücel, M. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413508455 · Cited by 213 · see citing works
Brain inflammation is induced by co-morbidities and risk factors for stroke
Drake, C., Boutin, H., Jones, M. S., Dénes, Á., McColl, B. W., Selvarajah, J. R., Hulme, S., Georgiou, R. F., Hinz, R., Gerhard, A., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.008 · Cited by 205 · see citing works
Mesolimbic Dopamine and the Regulation of Motivated Behavior
Salamone, J. D., Pardo, M., Yohn, S. E., López-Cruz, L., SanMiguel, N., & Correa, M. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_383 · Cited by 204 · see citing works
Stress-induced neuroinflammation: role of the toll-like receptor-4 pathway
Gárate, I., Garcia-Bueno, B., Madrigal, J. L. M., Caso, J. R., Alou, L., Gomez-Lus, M. L., Micó, J. A., & Leza, J. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.005 · Cited by 202 · see citing works
Chan, R. C. K., Shi, Y., Lai, M.-K., Wang, Y.-N., Wang, Y., & Kring, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035352 · Cited by 201 · see citing works
Capuron, L., Ravaud, A., Gualde, N., Bosmans, E., Dantzer, R., Maes, M., & Neveu, P. J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00030-0 · Cited by 201 · see citing works
The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine
Monteggia, L. M., Gideons, E., & Kavalali, E. T. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.006 · Cited by 198 · see citing works
Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.06.008 · Cited by 195 · see citing works
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies
Bressa, G. M. (1994) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb05403.x · Cited by 195 · see citing works
Novel therapeutic targets in depression: Minocycline as a candidate treatment
Soczynska, J. K., Mansur, R. B., Brietzke, E. M., Swardfager, W., Kennedy, S. H., Woldeyohannes, H. O., Powell, A. M., Manierka, M. S., & McIntyre, R. S. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.026 · Cited by 190 · see citing works
Self-citationLongevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine
Unger, R. H. (2005) · Biochimie · doi:10.1016/j.biochi.2004.11.014 · Cited by 184 · see citing works
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
Neurobehavioral deficits in db/db diabetic mice
Sharma, A. N., Elased, K. M., Garrett, T. L., & Lucot, J. B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.002 · Cited by 180 · see citing works
Berlin, I., Givry-Steiner, L., Lecrubier, Y., & Puech, A. (1998) · European Psychiatry · doi:10.1016/s0924-9338(98)80048-5 · Cited by 178 · see citing works
O’Leary, O. F., Bechtholt, A. J., Crowley, J. J., Hill, T. E., Page, M. E., & Lucki, I. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0728-9 · Cited by 177 · see citing works
Unipolar depression does not moderate responses to the Sweet Taste Test
Dichter, G. S., Smoski, M. J., Kampov-Polevoy, A. B., Gallop, R., & Garbutt, J. C. (2010) · Depression and Anxiety · doi:10.1002/da.20690 · Cited by 175 · see citing works
Behavioral activation system deficits predict the six-month course of depression
McFarland, B. R., Shankman, S. A., Tenke, C. E., Bruder, G. E., & Klein, D. N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.012 · Cited by 174 · see citing works
Visceral obesity and the heart
Mathieu, P., Pîbarot, P., Larose, É., Poirier, P., Marette, A., & Després, J. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.001 · Cited by 173 · see citing works
Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement
Noonan, M. P., Kolling, N., Walton, M. E., & Rushworth, M. F. S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08023.x · Cited by 169 · see citing works
Moreau, M. M., André, C., O’Connor, J. C., Dumich, S. A., Woods, J. A., Kelley, K. W., Dantzer, R., Lestage, J., & Castanon, N. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.001 · Cited by 168 · see citing works
Metabolic effects of interleukin‐6 in human splanchnic and adipose tissue
Lyngsø, D., Simonsen, L., & Bülow, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.021022 · Cited by 155 · see citing works
Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112458732 · Cited by 151 · see citing works
On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo
Amori, L., Guidetti, P., Pellicciari, R., Kajii, Y., & Schwarcz, R. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05893.x · Cited by 151 · see citing works
Depressive Symptoms in Adult Coeliac Disease
Ciacci, C. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850170801 · Cited by 151 · see citing works
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.014 · Cited by 144 · see citing works
Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients
Koziorowski, D., Tomasiuk, R., Szlufik, S., & Friedman, A. (2012) · Cytokine · doi:10.1016/j.cyto.2012.07.030 · Cited by 142 · see citing works
Keller, J., Young, C. B., Kelley, E., Prater, K. E., Levitin, D. J., & Menon, V. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.015 · Cited by 139 · see citing works
Papakostas, G. I., Shelton, R. C., Zajecka, J., Bottiglieri, T., Roffman, J. L., Cassiello-Robbins, C. F., Stahl, S. M., & D, M. F. M. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08947 · Cited by 139 · see citing works
Stress responses and the mesolimbic dopamine system: Social contexts and sex differences
Trainor, B. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.013 · Cited by 138 · see citing works
Davidson, K. W., Burg, M. M., Kronish, I. M., Shimbo, D., Dettenborn, L., Mehran, R., Vorchheimer, D. A., Clemow, L., Schwartz, J. E., & Rieckmann, N. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.36 · Cited by 138 · see citing works
Collin, M., Ovesjö, M., Misane, I., Ögren, S. O., & Meister, B. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00167-4 · Cited by 132 · see citing works
Mansvelder, H. D., De Rover, M., McGehee, D. S., & Brussaard, A. B. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.099 · Cited by 130 · see citing works
Liver–brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders
D’Mello, C., & Swain, M. G. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.009 · Cited by 129 · see citing works
Ertenli, İ., Ozer, S., Kiraz, S., Apras, S., Akdoğan, A., Karadağ, Ö., Çalgünerı, M., & Kalyoncu, U. (2010) · Rheumatology International · doi:10.1007/s00296-010-1616-x · Cited by 129 · see citing works
Depression pathogenesis and treatment: what can we learn from blood mRNA expression?
Hepgul, N., Cattaneo, A., Zunszain, P. A., & Pariante, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-28 · Cited by 127 · see citing works
Cardiovascular Biology of Interleukin-6
Abeywardena, M. Y., Leifert, W. R., Warnes, K., Varghese, J. N., & Head, R. J. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788186290 · Cited by 127 · see citing works
Pearlman, D. M., & Najjar, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.001 · Cited by 123 · see citing works
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Müller, N. (2010) · PubMed · Cited by 122 · see citing works
Krishnan, R. R., Cella, D. F., Leonardi, C., Papp, K. A., Gottlieb, A. B., Dunn, M. E., Chiou, C. F., Patel, V. D., & Jahreis, A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08205.x · Cited by 121 · see citing works
Interferon gama induced Tryptophan Degradation Neuropsychiatric and Immunological Consequences
Widner, B., Ledochowski, M., & Fuchs, D. (2000) · Current Drug Metabolism · doi:10.2174/1389200003339063 · Cited by 118 · see citing works
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.018 · Cited by 116 · see citing works
Self-citationBrunzell, D. H., & McIntosh, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.299 · Cited by 114 · see citing works
Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans
Hannestad, J., Subramanyam, K., DellaGioia, N., Planeta-Wilson, B., Weinzimmer, D., Pittman, B., & Carson, R. E. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.097014 · Cited by 113 · see citing works
Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes
Anisman, H., Kokkinidis, L., & Merali, Z. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00011-9 · Cited by 112 · see citing works
Exofocal Dopaminergic Degeneration as Antidepressant Target in Mouse Model of Poststroke Depression
Kronenberg, G., Balkaya, M., Prinz, V., Gertz, K. R., Ji, S., Kirste, I., Heuser, I., Kampmann, B., Hellmann‐Regen, J., Gass, P., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.026 · Cited by 111 · see citing works
A New Scale for Measuring Reward Responsiveness
Ivo, V. D. B., Franken, I. H. A., & Muris, P. (2010) · Frontiers in Psychology · doi:10.3389/fpsyg.2010.00239 · Cited by 110 · see citing works
Myint, A.-M., Steinbusch, H. W. M., Goeghegan, L., Luchtman, D. W., Kim, Y. K., & Leonard, B. E. (2007) · NeuroImmunoModulation · doi:10.1159/000107420 · Cited by 109 · see citing works
Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations
Ploder, M., Neurauter, G., Spittler, A., Schroecksnadel, K., Roth, E., & Fuchs, D. (2007) · Amino Acids · doi:10.1007/s00726-007-0625-x · Cited by 109 · see citing works
Maes, M. H. J., Bosmans, E., Suy, E., Vandervorst, C., Dejonckheere, C., & Raus, J. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90060-6 · Cited by 107 · see citing works
Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
Grillo, C. A., Piroli, G. G., Kaigler, K. F., Wilson, S. P., Wilson, M. A., & Reagan, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.052 · Cited by 103 · see citing works
Zangerle, R., Kurz, K., Neurauter, G., Kitchen, M., Sarcletti, M., & Fuchs, D. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.11.004 · Cited by 100 · see citing works
Sayd, A., Antón, M., Alén, F., Caso, J. R., Pavon, J., Leza, J. C., de Fonseca, F. R., García‐Bueno, B., & Orío, L. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu111 · Cited by 99 · see citing works
Major Depressive Disorder Predicts Completion, Adherence, and Outcomes in Cardiac Rehabilitation
Swardfager, W., Herrmann, N., Marzolini, S., Saleem, M., Farber, S. B., Kiss, A., OH, P. I., & Lanctôt, K. L. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05810blu · Cited by 97 · see citing works
Self-citationActivation of the kynurenine pathway is associated with striatal volume in major depressive disorder
Savitz, J. B., Dantzer, R., Meier, T. B., Wurfel, B. E., Victor, T. A., McIntosh, S. A., Ford, B. N., Morris, H. M., Bodurka, J., Teague, T. K., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.07.609 · Cited by 94 · see citing works
Kullmann, J. S., Grigoleit, J.-S., Lichte, P., Kobbe, P., Rosenberger, C., Banner, C., Wolf, O. T., Engler, H., Oberbeck, R., Elsenbruch, S., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22063 · Cited by 93 · see citing works
Denollet, J., Pedersen, S. S., Daemen, J., de Jaegere, P. P. T., Serruys, P. W. J. C., & van Domburg, R. T. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01870.x · Cited by 89 · see citing works
Blunted Sensitivity to Sucrose in Autoimmune MRL-lpr Mice: A Curve-Shift Study
Šakić, B., Denburg, J. A., Denburg, S. D., & Szechtman, H. (1996) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00190-6 · Cited by 87 · see citing works
Role of IL-1 in Poststroke Depressive-like Behavior in Mice
Craft, T. K. S., & DeVries, A. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.011 · Cited by 87 · see citing works
Feldman, S. R., Gottlieb, A. B., BALA, M. M., Wu, Y., Eisenberg, D. F., Guzzo, C. A., Li, S., Dooley, L. T., & Menter, A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08727.x · Cited by 86 · see citing works
Anhedonia in Parkinson's disease: A systematic review of the literature
Assogna, F., Cravello, L., Caltagirone, C., & Spalletta, G. (2011) · Movement Disorders · doi:10.1002/mds.23815 · Cited by 86 · see citing works
Interleukin-17 in post-stroke neurodegeneration
Swardfager, W., Winer, D. A., Herrmann, N., Winer, S., & Lanctôt, K. L. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.021 · Cited by 85 · see citing works
Self-citationVentura, R., Cabib, S., & Puglisi‐Allegra, S. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00581-x · Cited by 80 · see citing works
Inflammatory and Cell Death Pathways in Brain and Peripheral Blood in Parkinson’s Disease
Macchi, B., Paola, R. D., Marino‐Merlo, F., Felice, M. R., Cuzzocrea, S., & Mastino, A. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150225124928 · Cited by 80 · see citing works
Association of Vascular Factors With Apathy in Community-Dwelling Elderly Individuals
Ligthart, S. A., Richard, E., Fransen, N. L., Eurelings, L. S. M., Beem, L., Eikelenboom, P., van Gool, W. A., & Moll van Charante, E. P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1858 · Cited by 79 · see citing works
Tapia‐González, S., García-Segura, L. M., Tena‐Sempere, M., Frago, L. M., Castellano, J. M., Fuente-Martín, E., García‐Cáceres, C., Argente, J., & Chowen, J. A. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02113.x · Cited by 77 · see citing works
Wanaverbecq, N., Semyanov, A. V., Pavlov, I., Walker, M. C., & Kullmann, D. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1732-07.2007 · Cited by 73 · see citing works
Regulation of noradrenergic function by inflammatory cytokines and depolarization
Li, W., Knowlton, D. L., Woodward, W. R., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01890.x · Cited by 71 · see citing works
Laske, C., Zank, M., Klein, R., Stransky, E., Batra, A., Buchkremer, G., & Schott, K. J. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.023 · Cited by 71 · see citing works
Markers of gluten sensitivity and celiac disease in bipolar disorder
Dickerson, F., Stallings, C. R., Origoni, A. E., Vaughan, C., Khushalani, S., Alaedini, A., & Yolken, R. H. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00894.x · Cited by 71 · see citing works
Immunoglobulins, autoantibodies and other serum protein fractions in psychiatric disorders
Legros, S., Mendlewicz, J., & Wybran, J. (1985) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00380962 · Cited by 70 · see citing works
Folate, B12, and life course of depressive illness
LEVITT, A. J., & Joffe, R. T. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90266-7 · Cited by 70 · see citing works
The possible role of the kynurenine pathway in anhedonia in adolescents
Gabbay, V., Ely, B. A., Babb, J. S., & Liebes, L. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0685-7 · Cited by 66 · see citing works
Anhedonia in Parkinson’s Disease: An Overview
Loas, G., Krystkowiak, P. C., & Godefroy, O. (2012) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.11110332 · Cited by 66 · see citing works
Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance
Revelo, X. S., Tsai, S. J., Lei, H., Luck, H., Ghazarian, M., Tsui, H., Shi, S. Y., Schroer, S. A., Luk, C. T., Lin, G. H. Y., et al. (2014) · Diabetes · doi:10.2337/db13-1524 · Cited by 65 · see citing works
Stress-induced anhedonia is associated with an increase in Alzheimer’s disease-related markers
Briones, A., Gagno, S., Martisova, E., Dobarro, M., Aisa, B., Solas, M., Tordera, R., & Ramírez, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01602.x · Cited by 64 · see citing works
Grillo, C. A., Piroli, G. G., Junor, L., Wilson, S. P., Mott, D. D., Wilson, M. A., & Reagan, L. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.028 · Cited by 64 · see citing works
Neuropsychiatric Symptoms and Interleukin-6 Serum Levels in Acute Stroke
Spalletta, G., Cravello, L., Imperiale, F., Salani, F., Bossù, P., Picchetto, L., Cao, M., Rasura, M., Pazzelli, F., Orzi, F., et al. (2013) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.12120399 · Cited by 63 · see citing works
The Neurobiology of Motivational Deficits in Depression—An Update on Candidate Pathomechanisms
Treadway, M. T. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_400 · Cited by 63 · see citing works
Beggiato, S., Antonelli, T., Tomasini, M. C., Tanganelli, S., Fuxé, K., Schwarcz, R. M., & Ferraro, L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12160 · Cited by 60 · see citing works
The EAE-associated behavioral syndrome II. Modulation by anti-inflammatory treatments
Pollak, Y. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00073-0 · Cited by 56 · see citing works
Ritsner, M., Arbitman, M., & Lisker, A. (2011) · Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3182349ce6 · Cited by 55 · see citing works
The EAE-associated behavioral syndrome I. Temporal correlation with inflammatory mediators
Pollak, Y. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00075-4 · Cited by 55 · see citing works
Effect of aripiprazole on self-reported anhedonia in bipolar depressed patients
Mazza, M., Squillacioti, M. R., Pecora, R. D., Janiri, L., & Bria, P. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.003 · Cited by 54 · see citing works
Suboptimal glycemic control in type 2 diabetes: A key role for anhedonia?
Nefs, G., Pouwer, F., Denollet, J., Krämer, H. U., Gent, C., & Pop, V. J. M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.013 · Cited by 54 · see citing works
Swardfager, W., Herrmann, N., Dowlati, Y., Oh, P., Kiss, A., Walker, S., & Lanctôt, K. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.019 · Cited by 54 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
An active inference theory of allostasis and interoception in depression
Barrett, L. F., Quigley, K. S., & Hamilton, P. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0011 · Cited by 554 · see citing works
Kopschina Feltes, P., Doorduin, J., Klein, H. C., Juárez-Orozco, L. E., Dierckx, R. A., Moriguchi-Jeckel, C. M., & de Vries, E. F. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711708 · Cited by 279 · see citing works
Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258 · see citing works
Self-citationBorsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176 · see citing works
Cao, B., Zhu, J., Zuckerman, H., Rosenblat, J. D., Brietzke, E., Pan, Z., Subramanieapillai, M., Park, C., Lee, Y., & McIntyre, R. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.002 · Cited by 175 · see citing works
Self-citationTherapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Diet-Derived Fatty Acids, Brain Inflammation, and Mental Health
Melo, H. M., Santos, L. E., & Ferreira, S. T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00265 · Cited by 136 · see citing works
Juengst, S. B., Kumar, R. G., & Wagner, A. K. (2017) · Psychology Research and Behavior Management · doi:10.2147/prbm.s113264 · Cited by 102 · see citing works
Besteher, B., Gaser, C., & Nenadić, I. (2020) · Neuropsychobiology · doi:10.1159/000501024 · Cited by 83 · see citing works
Jha, M. K., Minhajuddin, A., Gadad, B. S., Greer, T. L., Mayes, T. L., & Trivedi, M. H. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.07.005 · Cited by 79 · see citing works
Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways
Jansen, P. R., Watanabe, K., Stringer, S., Skene, N., Bryois, J., Hammerschlag, A. R., de Leeuw, C. A., Benjamins, J., Muñoz-Manchado, A. B., Nagel, M., et al. (2018) · doi:10.1101/214973 · Cited by 860 · see citing works
- Authors
- Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S.
- Affiliations
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Swardfager, Walter
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 64
- Pages
- 148-166
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2284757052
- Cited by
- 125
- References
- 227
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 7 · 2023: 6 · 2022: 17 · 2021: 10 · 2020: 13 · 2019: 18 · 2018: 11 · 2017: 15 · 2016: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuroinflammation, anhedonia, mood, Research Domain Criteria, cell-mediated immunity, indoleamine 2,3-dioxygenase, tetrahydrobiopterin, oxidative inactivation, catecholamines, major depressive disorder, Alzheimer's disease, stroke, type 2 diabetes, infection, social processes
- MeSH terms
- Animals, Brain, Humans, Cytokines, Anhedonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review