Cited by 125Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Mapping inflammation onto mood: inflammatory mediators of anhedonia

Swardfager, Walter, Rosenblat, Joshua D., Benlamri, Meriem, McIntyre, Roger S.·2016·Neuroscience & Biobehavioral Reviews

Abstract

Evidence supports inflammatory involvement in mood and cognitive symptoms across psychiatric, neurological and medical disorders; however, inflammation is not a sensitive or specific characteristic of these diagnoses. The National Institute of Mental Health Research Domain Criteria (RDoC) ask for a shift away from symptom-based diagnoses toward a transdiagnostic neurobiological focus in the study of brain illnesses. The RDoC matrix may provide a useful framework for integrating the effects of inflammation on brain function. Based on preclinical and clinical findings, relevant relationships span negative and positive valence systems, cognitive systems, systems for social processes and arousal/regulatory systems. As an exemplar, we consider the psychopathological domain of anhedonia, conceptualizing the relevance of inflammation (e.g., cellular immunity) and downstream processes (e.g., indoleamine 2,3-dioxygenase activation and oxidative inactivation of tetrahydrobiopterin) across RDoC units of analysis (e.g., catecholamine neurotransmitter molecules, nucleus accumbens medium spiny neuronal cells, dopaminergic mesolimbic and mesocortical reward circuits, animal paradigms, etc.). We discuss implications across illnesses affecting the brain, including infection, major depressive disorder, stroke, Alzheimer's disease and type 2 diabetes.

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Crossref · 10.1016/j.neubiorev.2016.02.017

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Authors
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S.
Affiliations
  • University Health Network (CA)
  • University of Toronto (CA)
Corresponding author
Swardfager, Walter
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2016-05
Volume
64
Pages
148-166
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2284757052
Cited by
125
References
227
Citations by year
2026: 8 · 2025: 14 · 2024: 7 · 2023: 6 · 2022: 17 · 2021: 10 · 2020: 13 · 2019: 18 · 2018: 11 · 2017: 15 · 2016: 5
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
neuroinflammation, anhedonia, mood, Research Domain Criteria, cell-mediated immunity, indoleamine 2,3-dioxygenase, tetrahydrobiopterin, oxidative inactivation, catecholamines, major depressive disorder, Alzheimer's disease, stroke, type 2 diabetes, infection, social processes
MeSH terms
Animals, Brain, Humans, Cytokines, Anhedonia

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