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Cited by 945Nicotinic Acetylcholine Receptors StudyPesticide Exposure and ToxicityInsect Resistance and Genetics

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Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors

Matsuda, Kazuhiko, Buckingham, Steven D., Kleier, Daniel, Rauh, James J., Grauso, Marta, Sattelle, David B.·2001·Trends in Pharmacological Sciences
DOI 10.1016/s0165-6147(00)01820-4
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Abstract

Imidacloprid is increasingly used worldwide as an insecticide. It is an agonist at nicotinic acetylcholine receptors (nAChRs) and shows selective toxicity for insects over vertebrates. Recent studies using binding assays, molecular biology and electrophysiology suggest that both alpha- and non-alpha-subunits of nAChRs contribute to interactions of these receptors with imidacloprid. Electrostatic interactions of the nitroimine group and bridgehead nitrogen in imidacloprid with particular nAChR amino acid residues are likely to have key roles in determining the selective toxicity of imidacloprid. Chemical calculation of atomic charges of the insecticide molecule and a site-directed mutagenesis study support this hypothesis.

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Metadata

Authors
Matsuda, K., Buckingham, S. D., Kleier, D., Rauh, J. J., Grauso, M., & Sattelle, D. B.
Affiliations
  • Kindai University (JP)
  • Babraham Institute (GB)
  • DuPont (United States) (US)
  • University of Oxford (GB)
Corresponding author
Sattelle, David B.
ORCID
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2001-11
Volume
22
Issue
11
Pages
573-580
ISSN
0165-6147 (ISSN-L)
DOI
10.1016/s0165-6147(00)01820-4
OpenAlex
W2026963422
Cited by
945
References
0
Citations by year
2026: 39 · 2025: 37 · 2024: 50 · 2023: 46 · 2022: 52 · 2021: 65 · 2020: 73 · 2019: 61 · 2018: 54 · 2017: 51 · 2016: 58 · 2015: 40 · 2014: 44 · 2013: 28 · 2012: 43
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • HAL (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Keywords
neonicotinoids, imidacloprid, nicotinic acetylcholine receptors, insecticide selectivity, alpha subunit, electrostatic interactions, site-directed mutagenesis, insecticide binding
MeSH terms
Animals, Humans, Insecticides, Receptors, Nicotinic, Structure-Activity Relationship, Cholinergic Agents

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