Cited by 913Neurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural Mechanisms

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Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung, Catherine, Griebel, Guy·2001·Behavioural Brain Research

DOI 10.1016/s0166-4328(01)00291-1

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Abstract

Measuring anxiety-like behaviour in mice has been mostly undertaken using a few classical animal models of anxiety such as the elevated plus-maze, the light/dark choice or the open-field tests. All these procedures are based upon the exposure of subjects to unfamiliar aversive places. Anxiety can also be elicited by a range of threats such as predator exposure. Furthermore, the concepts of "state" and "trait" anxiety have been proposed to differentiate anxiety that the subject experiences at a particular moment of time and that is increased by the presence of an anxiogenic stimulus, and anxiety that does not vary from moment to moment and is considered to be an "enduring feature of an individual". Thus, when assessing the behaviour of mice, it is necessary to increase the range of behavioural paradigms used, including animal models of "state" and "trait" anxiety. In the last few years, many mice with targeted mutations have been generated. Among them some have been proposed as animal models of pathological anxiety, since they display high level of anxiety-related behaviours in classical tests. However, it is important to emphasise that such mice are animal models of a single gene dysfunction, rather than models of anxiety, per se. Inbred strains of mice, such as the BALB/c line, which exhibits spontaneously elevated anxiety appear to be a more suitable model of pathological anxiety.

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The use of a plus-maze to measure anxiety in the mouse
Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617
DSM-IV: Diagnostic and Statistical Manual of Mental Disorders
Bell, C. C. (1994) · JAMA · doi:10.1001/jama.1994.03520100096046 · Cited by 2,608
Contingencies of reinforcement : a theoretical analysis
Skinner, B. F. (1969) · Medical Entomology and Zoology · Cited by 1,560
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437
The Conduct of Inquiry
Salas, M. D. L. N. J., & Kaplan, A. (1967) · Revista española de la opinión pública · doi:10.2307/40180865 · Cited by 1,362
Le normal et le pathologique
Canguilhem, G. (2013) · Presses Universitaires de France eBooks · doi:10.3917/puf.cangu.2013.01 · Cited by 1,301
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety
Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1×
“Other authors [58,84,90] have proposed additional criteria.”
The Conduct of Inquiry: Methodology for Behavioral Science.
Nagel, E., & Kaplan, A. (1965) · American Sociological Review · doi:10.2307/2091353 · Cited by 1,155
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918

Show all 97 references

Research works printed but not linked: 4

Bhattacharya, 1993, Further investigations on the anxiogenic action of isatin, Biogenic Amines, 9, 5
Pattij, 2000, Does the 5-HT1A receptor knockout mouse have an anxious phenotype?, Int. J. Psychopharmacol., 3, S275
Ramesh, 1998, Altered physiological and behavioral responses in CRH-binding protein deficient mice, Soc. Neurosci. Abstr., 24, 505
Vasar, 2000, CCKB receptor knockout mice: gender related behavioural differences, Eur. Neuropsychopharmacol., 10, S69

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Authors: Belzung, C., & Griebel, G.
Affiliations: Université de Tours (FR)
Sanofi (France) (FR)
Corresponding author: Belzung, Catherine
ORCID: Belzung, Catherine
Griebel, Guy
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2001-11
Volume: 125
Issue: 1-2
Pages: 141-149
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(01)00291-1
OpenAlex: W1977118330
Cited by: 912
References: 97
Citations by year: 2026: 16 · 2025: 30 · 2024: 17 · 2023: 32 · 2022: 35 · 2021: 32 · 2020: 38 · 2019: 38 · 2018: 44 · 2017: 47 · 2016: 46 · 2015: 42 · 2014: 46 · 2013: 46 · 2012: 48
FWCI: 7.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: anxiety-like behavior, elevated plus maze, open field test, predator exposure, state anxiety, trait anxiety, animal models of anxiety, inbred mouse strains, BALB/c mice, pathological anxiety
MeSH terms: Animals, Anxiety, Arousal, Behavior, Animal, Humans, Mice, Inbred BALB C, Mice, Inbred Strains, Mice, Mutant Strains, Mice, Transgenic, Models, Genetic, Phenotype, Mice, Knockout, Mice

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Measuring normal and pathological anxiety-like behaviour in mice: a review

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