Cited by 913Neurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural Mechanisms

The DOI matches its Crossref record; 91 of the 97 references it cites were found in a registry or an index.

Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung, Catherine, Griebel, Guy·2001·Behavioural Brain Research

DOI 10.1016/s0166-4328(01)00291-1

Open this paper in CoChat — free account

Abstract

Measuring anxiety-like behaviour in mice has been mostly undertaken using a few classical animal models of anxiety such as the elevated plus-maze, the light/dark choice or the open-field tests. All these procedures are based upon the exposure of subjects to unfamiliar aversive places. Anxiety can also be elicited by a range of threats such as predator exposure. Furthermore, the concepts of "state" and "trait" anxiety have been proposed to differentiate anxiety that the subject experiences at a particular moment of time and that is increased by the presence of an anxiogenic stimulus, and anxiety that does not vary from moment to moment and is considered to be an "enduring feature of an individual". Thus, when assessing the behaviour of mice, it is necessary to increase the range of behavioural paradigms used, including animal models of "state" and "trait" anxiety. In the last few years, many mice with targeted mutations have been generated. Among them some have been proposed as animal models of pathological anxiety, since they display high level of anxiety-related behaviours in classical tests. However, it is important to emphasise that such mice are animal models of a single gene dysfunction, rather than models of anxiety, per se. Inbred strains of mice, such as the BALB/c line, which exhibits spontaneously elevated anxiety appear to be a more suitable model of pathological anxiety.

Integrity signals

Registry

Crossref · 10.1016/s0166-4328(01)00291-1

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The use of a plus-maze to measure anxiety in the mouse
Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617
DSM-IV: Diagnostic and Statistical Manual of Mental Disorders
Bell, C. C. (1994) · JAMA · doi:10.1001/jama.1994.03520100096046 · Cited by 2,608
Contingencies of reinforcement : a theoretical analysis
Skinner, B. F. (1969) · Medical Entomology and Zoology · Cited by 1,560
Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437
The Conduct of Inquiry
Salas, M. D. L. N. J., & Kaplan, A. (1967) · Revista española de la opinión pública · doi:10.2307/40180865 · Cited by 1,362
Le normal et le pathologique
Canguilhem, G. (2013) · Presses Universitaires de France eBooks · doi:10.3917/puf.cangu.2013.01 · Cited by 1,301
A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety
Hogg, S. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02126-4 · Cited by 1,169
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 1×
“Other authors [58,84,90] have proposed additional criteria.”
The Conduct of Inquiry: Methodology for Behavioral Science.
Nagel, E., & Kaplan, A. (1965) · American Sociological Review · doi:10.2307/2091353 · Cited by 1,155
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918

Show all 97 references

Research works printed but not linked: 4

Bhattacharya, 1993, Further investigations on the anxiogenic action of isatin, Biogenic Amines, 9, 5
Pattij, 2000, Does the 5-HT1A receptor knockout mouse have an anxious phenotype?, Int. J. Psychopharmacol., 3, S275
Ramesh, 1998, Altered physiological and behavioral responses in CRH-binding protein deficient mice, Soc. Neurosci. Abstr., 24, 505
Vasar, 2000, CCKB receptor knockout mice: gender related behavioural differences, Eur. Neuropsychopharmacol., 10, S69

Sorted by citations

Items 601–700 of 913

Prepartum and Postpartum Open-Field Behavior and Maternal Responsiveness in Mice Bidirectionally Selected for Open-Field Thigmotaxis
Leppänen, P. K., Ravaja, N., & Ewalds‐Kvist, S. B. M. (2008) · The Journal of General Psychology · doi:10.3200/genp.135.1.37-53 · Cited by 9
Aggression and anxiety in pregnant mice are modulated by offspring characteristics
D'Amato, F. R., Rizzi, R., & Moles, A. (2006) · Animal Behaviour · doi:10.1016/j.anbehav.2005.11.022 · Cited by 9
Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
Adongo, D. W., Mante, P. K., Kukuia, K. K. E., Ameyaw, E. O., Woode, E., & Azi, I. H. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0067 · Cited by 9
Experimental Evidence for Diiodohydroxyquinoline-Induced Neurotoxicity: Characterization of Age and Gender as Predisposing Factors
Kamel, A. S. E. D., Mohamed, A. F., Rabie, M. A., Elsherbiny, M. E., Ahmed, K. A., Khattab, M. M., & Abdelkader, N. F. (2022) · Pharmaceuticals · doi:10.3390/ph15020251 · Cited by 8
Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice
Woodward, E. M., Ringland, A., Ackerman, J., & Coutellier, L. D. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105997 · Cited by 8
Fear memory for cue and context: Opposite and time-dependent effects of a physiological dose of corticosterone in male BALB/c and C57BL/6J mice
Diamantopoulou, A., Oitzl, M. S., & Grauer, E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.016 · Cited by 8
Reprint of "Pharmacological study of the light/dark preference test in zebrafish (Danio rerio): Waterborne administration"
Magno, L. D. P., Fontes-Pereira, A. J., Gonçalves, B. M. N., & Gouvêia, A. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.11.001 · Cited by 8
Oxidative stress and cognition in ecology
Cram, D. L. (2022) · Journal of Zoology · doi:10.1111/jzo.13020 · Cited by 8
5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition
Duvvuri, V., Risbrough, V. B., Kaye, W. H., & Geyer, M. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.05.014 · Cited by 8
GABAA Receptor α1 Subunit (Gabra1) Knockout Mice: Review and New Results
Ye, G.-L., Baker, K. B., Mason, S. M., Zhang, W., Kirkpatrick, L., Lanthorn, T. H., & Savelieva, K. V. (2009) · Neuromethods · doi:10.1007/978-1-60761-474-6_4 · Cited by 8
Neurotoxin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Animal Models of Parkinson’s Disease
Kasahara, J., Choudhury, M. E., Nishikawa, N., Tanabe, A., Tsuji, R., Zhou, Y., Ogawa, M., Yokoyama, H., Tanaka, J., & Nomoto, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00041-3 · Cited by 8
Anxiolytic and hypnotic effects of Cocculus laurifolius leaf extract in mice
Maqbool, S., & Younus, I. (2019) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v14i1.38093 · Cited by 8
Preclinical models of irritable bowel syndrome
López‐Gómez, L., Bagüés, A., Uranga, J. A., & Abalo, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821324-7.00012-5 · Cited by 8
Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice
Noh, Y. W., Yook, C., Kang, J., Lee, S., Kim, Y., Yang, E., Kim, H., & Kim, E. (2022) · Communications Biology · doi:10.1038/s42003-022-03813-y · Cited by 8
Adaptive anxious states and down-regulation of dopamine activity under amygdala activation in rats
Lai, C., & Chang, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.12.049 · Cited by 8
Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission
Bechtholt, A. J., & Lucki, I. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-080-5_20 · Cited by 8
Toward collaborative artificial intelligence development for animal well-being
Sun, J. (2025) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.24.10.0650 · Cited by 7
The behavioural response of Great Tits to novel environment and handling is affected by the DRD4 gene
Timm, K., Mägi, M., Telve, K., & Tilgar, V. (2018) · Ibis · doi:10.1111/ibi.12604 · Cited by 7
Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: A potential role of adult hippocampal neurogenesis in “curiosity”
Mañas‐Padilla, M. C., Melgar‐Locatelli, S., Vicente, L., Gil‐Rodríguez, S., Rivera, P., Rodríguez‐Pérez, C., & Castilla‐Ortega, E. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25442 · Cited by 7
Social isolation leads to mild social recognition impairment and losses in brain cellularity
Guimarães, D. M., Valério‐Gomes, B., Vianna-Barbosa, R. J., Oliveira, W., Neves, G. A., Tovar-Moll, F. F., & Lent, R. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02705-z · Cited by 7
The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration
Voller, J., Potužáková, B., Šimeček, V., & Vožeh, F. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.11.005 · Cited by 7
NR2C by NR2B subunit exchange in juvenile mice affects emotionality and 5‐HT in the frontal cortex
Silva, M. A. D. S., Marchetti, L., Eisel, U. L. M., Huston, J. P., & Dere, E. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00274.x · Cited by 7
Atypical anxiolytic-like response to naloxone in benzodiazepine-resistant 129S2/SvHsd mice: role of opioid receptor subtypes
Rodgers, R. J., Augar, R., Berryman, N., Hansom, C. J., O’Mahony, M. L., Palmer, R. M., Stevens, A., & Tallett, A. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0435-y · Cited by 7
Neuroinflammation in Animal Models of Autism
Kazlauskas, N., Robinson‐Agramonte, M. D. L. Á., & Depino, A. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-16321-5_8 · Cited by 7
Neurobehavioral and Cardiovascular Effects of Potassium Cyanide Administered Orally to Mice
Hawk, M. A., Ritchie, G. D., Henderson, K. A., Knostman, K. A. B., Roche, B. M., Ma, Z. J., Matthews, C. M., Sabourin, C. L. K., Wakayama, E. J., & Sabourin, P. J. (2016) · International Journal of Toxicology · doi:10.1177/1091581816646974 · Cited by 7
Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain‐derived neurotrophic factor and GABA‐A receptor subunit
Li, H., Ishikawa, C., & Shiga, T. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.04.002 · Cited by 8
Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior
Fewou, S. N., Röckle, I., Hildebrandt, H., & Eckhardt, M. (2019) · Glycobiology · doi:10.1093/glycob/cwz040 · Cited by 7
Role of Lysophosphatidic Acid (LPA) in Behavioral Processes: Implications for Psychiatric Disorders
Estivill‐Torrús, G., Santín, L. J., Pedraza, C., Castilla‐Ortega, E., & de Fonseca, F. R. (2013) · Wiley eBooks · doi:10.1002/9781118531426.ch21 · Cited by 7
How much fear is in anxiety?Preprint
Genewsky, A. J., Albrecht, N., Bura, S. A., Kaplick, P. M., Heinz, D. E., Nußbaumer, M., Engel, M., Grünecker, B., Kaltwasser, S. F., Riebe, C. J. N., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/385823 · Cited by 7
A new stress model by predatory sound produces persistent anxiety-like behaviours in male SD rats but not ICR mice
Chen, C., Zhong, Z., Xin, Z., Zhang, S., & Yu, C. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.104843 · Cited by 6
Absence of anxiolytic activity of Sarcocephalus latifolius fruit extract
Arome, D., Chinedu, E., Mbonne, E., Monica, I., Agbafor, A., & Ameh, S. F. (2014) · Journal of Pharmaceutical Negative Results · doi:10.4103/0976-9234.136772 · Cited by 6
Fibroblast Growth Factor 8 Deficiency Compromises the Functional Response of the Serotonergic System to Stress
Brooks, L. R., Pals, H. L., Enix, C. L., Woolaver, R. A., Paul, E. D., Lowry, C. A., & Tsai, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101420 · Cited by 6
Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin
Vega, S. C., Leiss, V., Piekorz, R. P., Calaminus, C., Pexa, K., Vuozzo, M., Schmid, A. M., Devanathan, V., Kesenheimer, C., Pichler, B. J., et al. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01854-1 · Cited by 6
Anxiolytic and antipyretic properties of the root aqueous extract of Bombax costatum Pellegr. et Vuillet. (Bombacaceae) in mice: Implication of behavioural and neurochemical approaches
Wanbara, N., Taïwé, G. S., Njapdounké, J. S. K., Sidiki, N., Nlôga, A. M. N., & Bum, E. N. (2021) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2021.15.2.0133 · Cited by 7
The importance of individual variation for the interpretation of behavioural studies: ethanol effects vary with basal activity level in zebrafish larvae
Davis, R. L., Luchtenburg, F. J., Richardson, M. K., Schaaf, M. J. M., Tudorache, C., & Slabbekoorn, H. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05932-6 · Cited by 6
Constitutive Serotonin Tone Modulates Molecular and Behavioral Response to Chronic Fluoxetine Treatment: A Study on Genetic Rat Model
Kesić, M., Mokrović, G., Tvrdeić, A., Miše, B., Štefulj, J., & Čičin‐Šain, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.741222 · Cited by 6
Hyperthermia alters neurobehavior by affecting cell proliferation and neuronal survival in young male rats
Mete, F., Eyüboğlu, S., Vitrinel, A., Kılıç, Ü., Erdogan, C. S., Kılıç, E., & Yılmaz, B. (2023) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10258 · Cited by 6
Interleukin‐1β‐immunoreactive neurons in the hippocampus and paraventricular nucleus of the hypothalamus after stress stimulation in aged versus adult rats
Badowska‐Szalewska, E., Ludkiewicz, B., Spodnik, J. H., & Moryś, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23428 · Cited by 6
Impact of high and low anxiety trait on object habituation and discrimination: Evidence from selected lines of Japanese quail
Calandreau, L., Bertin, A., Favreau-Peigné, A., Richard, S., Constantin, P., Lansade, L., Arnould, C., & Leterrier, C. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.032 · Cited by 6
Anxiolytic and CNS depressant effects of ethanolic extract of cleome brachycarpa revealed after neuropharmacological screening
Sarfaraz, S. A., Najam, R., Azhar, I., Riaz, B., & Anser, H. (2014) · Cited by 6
Behavioural and Locomotor Measurements Using Open Field Animal Activity Monitoring System
Nagaraju, K. (2014) · Cited by 6
Animal Tests for Anxiety
Bertoglio, L. J., & Carobrez, A. P. (2015) · Springer eBooks · doi:10.1007/978-3-319-11578-8_18 · Cited by 6
Searching for neural and behavioral parameters that predict anti-aggressive effects of chronic SSRI treatment in rats
Peeters, D. G. A., Rietdijk, J., Gerrits, D., Rijpkema, M., de Boer, S. F., Verkes, R., & Homberg, J. R. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.012 · Cited by 6
New Anxiolytic Phytopharmaceutical Elaborated with the Standardized Extract of Galphimia glauca
Tortoriello, J., Herrera-Arellano, A., Herrera-Ruiz, M. L., Zamilpa, A., González‐Cortazar, M., & Enrique, J. (2011) · InTech eBooks · doi:10.5772/24294 · Cited by 6
CNS DEPRESSANT, SEDATIVE AND ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FRUIT OF PIPER CHABA REVEALED AFTER NEUROPHARMACOLOGICAL SCREENING
Sarfaraz, S. A., Najam, R., & Sarfaraz, A. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 6
Anticonvulsant and anxiolyic activities of ethyl acetate fraction of Cassia fistula Linn. pods in mice
Kalaiyarasi, C., Karthika, K., & Ragupathi, G. (2014) · Pharmacognosy Communications · doi:10.5530/pc.2015.1.8 · Cited by 6
Ansiedad, Memoria y el Trastorno de Estrés Post-Traumático
Blanco, M. B., & Canto‐de‐Souza, A. (2018) · CES Psicología · doi:10.21615/cesp.11.2.5 · Cited by 6
Neural Markers of Vulnerability to Anxiety Outcomes after Traumatic Brain Injury
Popovitz, J., Mysore, S. P., & Adwanikar, H. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7320 · Cited by 6
The relationship between locomotion and heat tolerance in heat exposed rats
Michel, V., Peinnequin, A., Alonso, A., Fidier, N., Maury, R., Drouet, J.-B., Buguet, A., Cespuglio, R., & Canini, F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.006 · Cited by 6
Ferulic acid possesses anxiolytic activity: evidence for the involvement of serotonergic and noradrenergic systems
Çetiner, Ö. P., Eken, H., Alyu, F., Arslan, R., & Bektaş, N. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138416 · Cited by 5
Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
Letenneur, V., Monnoye, M., Philippe, C., Holowacz, S., Rabot, S., Lepage, P., Jacouton, E., & Naudon, L. (2023) · Nutrients · doi:10.3390/nu15214635 · Cited by 6
Anxiolytic-induced attenuation of thigmotaxis in the Elevated Minus Maze
Pickles, A. R., & Hendrie, C. A. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.04.006 · Cited by 5
Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) attenuates depressive-like behavior and physiology via association with gut microbiota in BALB/c mice
Lee, Y., Yeo, S., Kim, B., Holzapfel, W. H., & Kang, H. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105692 · Cited by 6
Letrozole delays acquisition of water maze task in female BALB/c mice: Possible involvement of anxiety
Mamczarz, J., Lane, M. V., & Merchenthaler, I. J. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105524 · Cited by 5
Social experiences during adolescence affect anxiety-like behavior but not aggressiveness in male mice
Meyer, N., Jenikejew, J., Richter, S. H., Kaiser, S., & Sachser, N. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.017 · Cited by 5
Parental behavior and anxiety in isogenic and outbred mice given access to two types of nesting materials
Moreira, V., Mattaraia, V. G. D. M., Rodrigues, M. V., de Albuquerque, C. Z., & Moura, A. S. A. M. T. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.03.012 · Cited by 5
3Rs-based optimization of mice behavioral testing: The habituation/dishabituation olfactory test
Oummadi, A., Meyer-Dilhet, G., Béry, A., Aubert, A., Barone, P. R., Mortaud, S., Guillemin, G. J., Menuet, A., & Laugeray, A. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108550 · Cited by 5
No Significant Effects of Cellphone Electromagnetic Radiation on Mice Memory or Anxiety: Some Mixed Effects on Traumatic Brain Injured Mice
Qubty, D., Schreiber, S., Rubovitch, V., Boag, A., & Pick, C. G. (2021) · Neurotrauma Reports · doi:10.1089/neur.2021.0009 · Cited by 5
Anxiety-like behavior and tectal gene expression in a foraging/predator avoidance tradeoff task using adult African clawed frogs Xenopus laevis
Menon, N., & Carr, J. A. (2022) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-022-03219-0 · Cited by 5
EFEITO PROTETOR DO RESVERATROL NA DOENÇA DE ALZHEIMER
Rosa, M. D. O., Machado, F. D. S., Frusciante, M. R., Gutierrez, L. L. P., & Funchal, C. (2017) · Revista Brasileira Multidisciplinar · doi:10.25061/2527-2675/rebram/2017.v20i1.477 · Cited by 5
Investigation of Anti-anxiety Activity of Hydroalcoholic Extract of Plectranthus scutellarioides Leaves in Experimental Animal Models
Shanbhag, P., Bhat, R., Mestha, S. V., Nagesh, S., & Nayak, R. K. (2022) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2022.v76i01.021 · Cited by 5
Modelling Anxiety in Humans for Drug Development
Siepmann, M., & Joraschky, P. (2007) · Current Neuropharmacology · doi:10.2174/157015907780077114 · Cited by 8
Aged wild-type littermates and APPswe+PS1/ΔE9 mice present similar deficits in associative learning and spatial memory independent of amyloid load
Park, S., Ko, H., Lee, N., Lee, H., Rim, E. Y., Kim, H., Lee, K., & Kaang, B. (2010) · Genes & Genomics · doi:10.1007/s13258-010-0833-8 · Cited by 5
Acute and subchronic effects of agmatine on anxiety tested in the elevated plus maze in male mice
Navarro, J. F., Luna, G., & García, F. B. (2005) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 5
Ethoexperimental studies of behaviour in wild and laboratory mice
Augustsson, H. (2004) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 5
Repeated behavioral testing and the use of summary measures reveal trait anxiety in preclinical rodent models
Varga, Z. K., Pejtsik, D., Tóth, M., Balogh, Z., Aliczki, M., Szente, L., Balla, G. Y., Kontra, L., Eckert, Z., Szebik, H., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03586-y · Cited by 4
Lost in translation: toward clinically effective translational research
Tan, V. T. Y., & Ward, R. D. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03688-7 · Cited by 4
Locus coeruleus microcircuitry processes periaqueductal gray inputs into distinct outputs for regulation of pain and anxiety
Harding, E. K., Zhang, Z., Yu, W. L., Ferron, L., van den Hoogen, N. J., Trang, T., & Zamponi, G. W. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116699 · Cited by 4
Maternal immune activation in mice recapitulates features of attention-deficit/hyperactivity disorder (ADHD) in susceptible offspring
Schaer, R., Wenger, N., Steiner, S., Notter, T., & Meyer, U. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02373-7 · Cited by 4
Travel‐Related Change of Residence Leads to a Transitory Stress Reaction in Humans
Blasche, G., Weissensteiner, K., & Marktl, W. (2012) · Journal of Travel Medicine · doi:10.1111/j.1708-8305.2012.00624.x · Cited by 4
Behavioral phenotyping of mice deficient in the tumor necrosis factor
Фурсенко, Д. В., Хоцкин, Н. В., Kulikov, V. A., & Kulikov, A. V. (2016) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059716040067 · Cited by 4
Can Anxiety Tested in the Elevated Plus-maze Be Related to Nociception Sensitivity in Adult Male Rats?
Pometlová, M., Yamamotová, A., Nohejlová, K., & Šlamberová, R. (2016) · Prague Medical Report · doi:10.14712/23362936.2016.19 · Cited by 4
Neuroanatomical pathways underlying the effects of hypothalamo-hypophysial-adrenal hormones on exploratory activity
Lalonde, R., & Strazielle, C. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0075 · Cited by 4
Dealing with COVID-19 stressful events, stress and anxiety: the mediating role of emotion regulation strategies in Italian women
Maggio, I. D., Romola, M., Lacava, E., Maressa, R., & Bruno, F. (2022) · Health Psychology Report · doi:10.5114/hpr/152331 · Cited by 4
The effect of chronic stress on the immunogenicity and immunoprotection of the M6-TT vaccine in female mice
Méndez, S. B., Matus-Ortega, M., Hernández-Miramontes, R., & Salazar‐Juárez, A. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114345 · Cited by 4
Modifi cation of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist
Lyudyno, V. I., Tsikunov, S. G., Abdurasulova, I. N., Кусов, А. Г., & Клименко, В. М. (2015) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-015-2958-x · Cited by 4
Communal breeding affects offspring behaviours associated with a competitive social environment
Fischer, S., Pujol, N. T., Bolton, R. L., Hurst, J. L., & Stockley, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-35089-w · Cited by 4
SURGICAL TREATMENT OF PATIENTS WITH COMBINED ATHEROSCLEROTIC DISEASE OF CAROTID AND CORONARY ARTERIES
Horev, N. G., Ermolin, P. A., Dispensary, A. R. C., Av, S., Dispensary, A. R. C., Kosouhov, A. P., Dispensary, A. R. C., Duda, A. I., Dispensary, A. R. C., Конькова, В. О., et al. (2018) · Bulletin of Medical Science · doi:10.31684/2541-8475.2018.1(9).61-67 · Cited by 4
Neuropharmacological Profile of Fractions of Actaea acuminata H. Hara Roots
Kumar, D., & Kumar, S. (2018) · Journal of Pharmaceutical Technology Research and Management · doi:10.15415/jptrm.2018.61001 · Cited by 4
Rotated nursing environment with underfeeding: A form of early-life adversity with sex- and age-dependent effects on coping behavior and hippocampal neurogenesis
Guzman, R. M. D., Medina, J., Saulsbery, A. I., & Workman, J. L. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113106 · Cited by 4
Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity
Mitra, S., & Bult‐Ito, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.716619 · Cited by 4
Long-term cardiovascular autonomic responses to aqueous ethanolic extract of Boophone disticha bulb in early maternally separated BALB/c mice
Pote, W., Tagwireyi, D., Chinyanga, H. M., Musara, C., Pfukenyi, D. M., Nkomozepi, P., Gadaga, L. L., Nyandoro, G., & Chifamba, J. (2014) · South African Journal of Botany · doi:10.1016/j.sajb.2014.04.012 · Cited by 4
Transformation of Catalytic Characteristics of Cerebral Monoamine Oxidases in Experimental Posttraumatic Stress Disorders
Колесникова, Л. И., Попова, А. С., Deev, R. V., Синицкий, А. И., & Krupitskaia, L. I. (2015) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-015-2826-8 · Cited by 4
Telemetry in Mice: Applications in Studies of Stress and Anxiety Disorders
Sanford, L. D., Yang, L., & Wellman, L. L. (2011) · Neuromethods · doi:10.1007/978-1-61779-313-4_3 · Cited by 4
Long-Term Changes in Spontaneous Behavior and c-Fos Expression in the Brain in Mice in the Resting State in a Model of Post-Traumatic Stress Disorder
Toropova, K. A., Ivashkina, O. I., Ivanova, A., Коновалова, Е. В., Dolgov, O., & Anokhin, K. V. (2021) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-021-01116-z · Cited by 5
Developing behavioral assays to study dopamine-related disorders in zebrafish (Danio rerio)
Bjerke, S. (2002) · NORA - Norwegian Open Research Archives · Cited by 4
Dopamine D1 receptor activation shapes anterior insula neural coding of anxietyPreprint
Couderc, Y., Reddy, T., Garg, A., Ricci, D., Vardiero, G., D'Almeida, M., Nicolas, C., Bordes, J., HABCHI, T., Penet, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.25.620186 · Cited by 4
Challenges in cross-test comparison of anxiety-related outcomes in rodents: A network meta-analysis
Yıldırım, D. D., Çevik, Ö. S., Horata, E., & Uzun, Ç. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174116 · Cited by 3
Comparison of Anxiolytic Effect of Matricaria Recutita in Male and Female Mice in the Presence and Absence of Gonads
Rad, G. P., & Kesmati, M. (2009) · Zahedan Journal of Research in Medical Sciences · Cited by 3
Germ-Free Animals
Luczynski, P., Neufeld, K. M., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00007-4 · Cited by 3
Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness
Xu, P., Liu, Y., Wang, L., Wu, Y., Zhou, X., Xiao, J., Zheng, J., & Xue, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-38305-9 · Cited by 3
Effects of acute maternal stress induced by predator cues on spatial learning and memory of offspring in the subterranean rodent Ctenomys talarum
Iribarne, J., Brachetta, V., Kittlein, M. J., Schleich, C. E., & Zenuto, R. R. (2023) · Animal Cognition · doi:10.1007/s10071-023-01822-w · Cited by 3
Differential strain sensitivity to low-dose anxiolytic diazepam in anxiety-related behaviour in male Wistar and Wistar-Kyoto, a rat model of endogenous depression
Inavally, A. T., & Sadananda, M. (2024) · Indian Journal of Physiology and Pharmacology · doi:10.25259/ijpp_431_2023 · Cited by 3
Innate visual attraction before, during and after escape from adverse substrates in carpenter ants
Notomi, Y., Dobata, S., Kazawa, T., Maezawa, S., Namiki, S., Kanzaki, R., & Haupt, S. S. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.250278 · Cited by 3
Brain changes associated with thromboxane receptor antagonist SQ 29,548 treatment in a mouse model
Rebel, A. A., Urquhart, S. A., Puig, K. L., Ghatak, A., Brose, S. A., Golovko, M. Y., & Combs, C. K. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23578 · Cited by 3
NEUROPHARMACOLOGICAL SCREENING OF ZAMZAM WATER REVEALED ITS ANXIOLYTIC AND ANTIDEPRESSANT EFFECT
Najam, R., & Riaz, B. (2016) · International Journal of Therapeutic Applications · doi:10.20530/ijta_32_41-47 · Cited by 3
Lethal Yellow Mutation Causes Anxiety, Obsessive-compulsive Behavior and Affects the Brain Melanocortin System in Males and Females of Mice
Хоцкин, Н. В., Izyurov, A. E., Plyusnina, A. V., Kulikova, E. A., & Kulikov, A. V. (2023) · Current Protein and Peptide Science · doi:10.2174/1389203724666230320145556 · Cited by 3
Early life events, but not response to a short photoperiod, correlate with foraging behaviour of Siberian hamsters
Przybylska-Piech, A. S., Wojciechowski, M. S., Wojciechowska, A., Nowak, A., & Jefimow, M. (2023) · Animal Behaviour · doi:10.1016/j.anbehav.2023.08.007 · Cited by 3
MK-801 attenuates one-trial tolerance in the elevated plus maze via the thalamic nucleus reuniens
Xu, X., Gong, Q., & Wang, X. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110318 · Cited by 3
A Comprehensive Review of Experimental Models of Stress: Pragmatic Insight Into Psychoneuroimmunology
Nisha, A., Shamim, A., Rizvi, A., Mahmood, T., Goswami, B., Ahsan, F., Sharique, M., & Parveen, S. (2025) · Health care science · doi:10.1002/hcs2.70002 · Cited by 3

Authors: Belzung, C., & Griebel, G.
Affiliations: Université de Tours (FR)
Sanofi (France) (FR)
Corresponding author: Belzung, Catherine
ORCID: Belzung, Catherine
Griebel, Guy
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2001-11
Volume: 125
Issue: 1-2
Pages: 141-149
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(01)00291-1
OpenAlex: W1977118330
Cited by: 912
References: 97
Citations by year: 2026: 16 · 2025: 30 · 2024: 17 · 2023: 32 · 2022: 35 · 2021: 32 · 2020: 38 · 2019: 38 · 2018: 44 · 2017: 47 · 2016: 46 · 2015: 42 · 2014: 46 · 2013: 46 · 2012: 48
FWCI: 7.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: anxiety-like behavior, elevated plus maze, open field test, predator exposure, state anxiety, trait anxiety, animal models of anxiety, inbred mouse strains, BALB/c mice, pathological anxiety
MeSH terms: Animals, Anxiety, Arousal, Behavior, Animal, Humans, Mice, Inbred BALB C, Mice, Inbred Strains, Mice, Mutant Strains, Mice, Transgenic, Models, Genetic, Phenotype, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measuring normal and pathological anxiety-like behaviour in mice: a review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks