The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Differential involvement of the shell and core subterritories of the nucleus accumbens in latent inhibition and amphetamine-induced activity
Abstract
Latent inhibition (LI) consists of retardation in conditioning to a stimulus as a consequence of its prior non-reinforced pre-exposure. In view of findings that LI is disrupted in acute schizophrenic patients and evidence from animal experiments pointing to the involvement of the mesolimbic dopamine (DA) system in this phenomenon, the present study investigated the effects of electrolytic lesions to the shell and core subterritories of the nucleus accumbens on LI in rats (Expt. 1). LI was indexed by the amount of suppression of drinking in the presence of a tone that was either pre-exposed or not prior to its pairing with reinforcement (a foot shock). Expt.2 tested the effects of the DA antagonist, haloperidol, on LI in shell- and core-lesioned animals. Expt. 3 tested the effects of shell and core lesions on spontaneous and amphetamine-induced locomotion. In Expt. 1, LI, i.e., lower suppression of drinking in the pre-exposed as compared to the non-pre-exposed animals, was obtained in the sham-operated condition. Core and shell lesions produced distinct effects on LI. Animals with core lesions developed LI, but exhibited an overall lower suppression of drinking in comparison to the sham-operated animals. In contrast, shell lesions led to a disappearance of LI. Expt. 2 replicated the differential effects of shell and core lesions on LI, although in this experiment, core lesion did not attenuate suppression of drinking. Haloperidol prevented shell-induced abolition of LI. In Exp…
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“Lesions to the nucleus accumbens can produce perseverative responding, impair reversal learning, and reduce behavioural switching [69–71].”
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Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Alcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 661
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
Meyer, U., Feldon, J., Schedlowski, M., & Yee, B. K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.012 · Cited by 494
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Metadata
- Authors
- Weiner, I., Gal, G., Rawlins, J. N. P., & Feldon, J.
- Affiliations
- Tel Aviv University (IL)
- University of Oxford (GB)
- Corresponding author
- Weiner, I.
- ORCID
- Gal, G.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 81
- Issue
- 1-2
- Pages
- 123-133
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2056093189
- Cited by
- 146
- References
- 85
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tel Aviv University
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- latent inhibition, nucleus accumbens shell, nucleus accumbens core, mesolimbic dopamine system, dopamine antagonism, haloperidol, amphetamine-induced locomotion, schizophrenia, electrolytic lesions, pre-exposure
- MeSH terms
- Amphetamine, Animals, Conditioning, Operant, Drinking, Emotions, Haloperidol, Handling, Psychological, Male, Motor Activity, Nucleus Accumbens, Stimulation, Chemical, Rats, Wistar, Dopamine Antagonists, Dopamine Uptake Inhibitors, Rats
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