The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Abstract
We isolated cDNA encoding a novel FGF (210 amino acids) from mouse embryos. As this is the 21st documented FGF, we tentatively term it FGF-21. FGF-21 has a hydrophobic amino terminus ( approximately 30 amino acids), which is a typical signal sequence, and appears to be a secreted protein. The expression of FGF-21 mRNA in mouse adult tissues was examined by Northern blotting analysis. FGF-21 mRNA was most abundantly expressed in the liver, and also expressed in the thymus at lower levels. We also isolated human cDNA encoding FGF-21 (209 amino acids). Human FGF-21 is highly identical ( approximately 75% amino acid identity) to mouse FGF-21. Among human FGF family members, FGF-21 is most similar ( approximately 35% amino acid identity) to FGF-19.
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“FGF21, unlike traditional FGFs, is an endocrine hormone produced and secreted predominantly by the liver [129,130].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [129]
Citations
Cites
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The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function
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Mitochondria: In Sickness and in Health
Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Ornitz, D. M., & Itoh, N. (2001) · Genome biology · doi:10.1186/gb-2001-2-3-reviews3005 · Cited by 1,985
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
Metadata
- Authors
- Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Itoh, Nobuyuki
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 1492
- Issue
- 1
- Pages
- 203-206
- ISSN
- 0167-4781 (ISSN-L)
- OpenAlex
- W1989584881
- Cited by
- 847
- References
- 21
- Citations by year
- 2026: 14 · 2025: 48 · 2024: 63 · 2023: 47 · 2022: 41 · 2021: 62 · 2020: 49 · 2019: 56 · 2018: 41 · 2017: 46 · 2016: 53 · 2015: 53 · 2014: 43 · 2013: 34 · 2012: 44
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- FGF21, fibroblast growth factor, liver-specific gene expression, thymus, signal peptide, secreted proteins, cDNA cloning, mouse embryo, FGF19, amino acid sequence identity, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Embryo, Mammalian, Fibroblast Growth Factors, Humans, Liver, Molecular Sequence Data, Phylogeny, Sequence Homology, Amino Acid, DNA, Complementary, Mice
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