Mitochondria: In Sickness and in Health
Open accessAbstract
Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism's physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.
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Detection of mitochondrial motives by innate and adaptive immunity might elicit potent pro-inflammatory responses.
“Given the bacterial features of mitochondria, the detection of mitochondrial motives by cells of the innate and adaptive immunity might elicit potent pro-inflammatory responses147,276,277.”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [277]
The Introduction describes mitochondria’s bacterial ancestry, and “Mitochondrial Defects Cause Diverse and Complex Human Diseases” says that the innate immune system recognizes and targets mouse cells with allogenic mtDNA. Our copy does not say that adaptive immunity detects mitochondrial motifs or that such detection elicits potent pro-inflammatory responses. (LLM, conf=0.82)
Experimental — accuracy not yet measuredMitochondria are the primary producers of intracellular reactive oxygen species and are susceptible to oxidative stress caused by toxic metabolites such as β-amyloid.
“Mitochondria not only generate ATP but also act as the primary producers of intracellular reactive oxygen species (ROS) and are susceptible to oxidative stress caused by various toxic metabolites, such as β‐amyloid (Aβ) [3, 4].”
From Aerobic exercise improves astrocyte mitochondrial quality and transfer to neurons in a mouse model of Alzheimer's disease (2025) · cites this paper as [3]
The section “Mitochondria Are Metabolic Signaling Centers” states that mitochondrial complexes I and III generate ROS, and the paper also describes mitochondrial ATP production. It does not establish that mitochondria are the primary intracellular ROS producers or say that β-amyloid causes oxidative stress in mitochondria; searches for amyloid and Alzheimer-related oxidative stress did not find that link. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredMOMP eventually leads to the dissipation of the mitochondrial transmembrane potential (Δψm)-mostly as a consequence of the respiratory impairment imposed by the loss of CYCS-and hence to the cessation of Δψm-dependent mitochondrial functions (including ATP synthesis and some forms of protein import).
“Of note, MOMP eventually leads to the dissipation of the mitochondrial transmembrane potential (Δψm)—mostly as a consequence of the respiratory impairment imposed by the loss of CYCS—and hence to the cessation of Δψm-dependent mitochondrial functions (including ATP synthesis and some forms of protein import) [200–203].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [200]
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“, Parkinson’s and Alzheimer’s disease) disorders [13].”
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“Discussion Mitochondria play critical roles in a variety of cellular functions, such as energy production, calcium homeostasis, and apoptosis [44].”
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“We increasingly recognise that mtDNA defects not only impact upon mitochondrial and cellular function but whole organism metabolism [58] .”
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- Authors
- Nunnari, J., & Suomalainen, A.
- Affiliations
- University of California, Davis (US)
- University of Helsinki (FI)
- Corresponding author
- Nunnari, Jodi
- Suomalainen, Anu
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 148
- Issue
- 6
- Pages
- 1145-1159
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5381524
- OpenAlex
- W2131415852
- Cited by
- 3,479
- References
- 243
- Citations by year
- 2026: 290 · 2025: 372 · 2024: 418 · 2023: 313 · 2022: 316 · 2021: 292 · 2020: 277 · 2019: 213 · 2018: 193 · 2017: 182 · 2016: 163 · 2015: 150 · 2014: 147 · 2013: 108 · 2012: 43
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Jane ja Aatos Erkon Säätiö
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM062942, R01GM097432)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondria, mitochondrial dysfunction, ATP production, biosynthetic intermediates, autophagy, apoptosis, mitochondrial dynamics, intercellular communication, neurodegenerative diseases, metabolic disorders
- MeSH terms
- Animals, Autophagy, Humans, Mitochondria, Apoptosis, Neurodegenerative Diseases, Mitochondrial Diseases
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