Cited by 868Protein Interaction Studies and Fluorescence AnalysisProtein Structure and DynamicsEnzyme Structure and Function

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The lipocalin protein family: structural and sequence overview

Flower, Darren R., North, Anthony C.T., Sansom, Clare E.·2000·Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

DOI 10.1016/s0167-4838(00)00148-5

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Abstract

Lipocalins are remarkably diverse at the sequence level yet have highly conserved structures. Most lipocalins share three characteristic conserved sequence motifs - the kernel lipocalins - while others are more divergent family members - the outlier lipocalins - typically sharing only one or two. This classification is a useful tool for analysing the family, and within these large sets are smaller groups sharing much higher levels of sequence similarity. The lipocalins are also part of a larger protein superfamily: the calycins, which includes the fatty acid binding proteins, avidins, a group of metalloproteinase inhibitors, and triabin. The superfamily is characterised by a similar structure (a repeated +1 topology beta-barrel) and by the conservation of a remarkable structural signature.

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Authors: Flower, D. R., North, A. C. T., & Sansom, C. E.
Affiliations: Jenner Institute (GB)
University of Leeds (GB)
University of London (GB)
Corresponding author: Flower, Darren R.
ORCID: Flower, Darren R.
Venue: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Publisher: Elsevier BV
Published: 2000-10
Volume: 1482
Issue: 1-2
Pages: 9-24
ISSN: 0167-4838 (ISSN-L)
DOI: 10.1016/s0167-4838(00)00148-5
OpenAlex: W2038438679
Cited by: 868
References: 59
Citations by year: 2026: 18 · 2025: 26 · 2024: 25 · 2023: 27 · 2022: 29 · 2021: 33 · 2020: 37 · 2019: 27 · 2018: 29 · 2017: 35 · 2016: 46 · 2015: 39 · 2014: 51 · 2013: 37 · 2012: 60
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: lipocalin, protein superfamilies, conserved motifs, fatty acid binding protein, avidin, metalloproteinase inhibitors, protein structure conservation
MeSH terms: Fatty Acid-Binding Protein 7, Amino Acid Sequence, Animals, Carrier Proteins, Humans, Lactoglobulins, Models, Molecular, Molecular Sequence Data, Neoplasm Proteins, Protein Conformation, Sequence Homology, Amino Acid, Insect Proteins, Tumor Suppressor Proteins, Fatty Acid-Binding Proteins

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The lipocalin protein family: structural and sequence overview

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