The commercial production of chemicals using pathway engineering
Abstract
Integration of metabolic pathway engineering and fermentation production technologies is necessary for the successful commercial production of chemicals. The 'toolbox' to do pathway engineering is ever expanding to enable mining of biodiversity, to maximize productivity, enhance carbon efficiency, improve product purity, expand product lines, and broaden markets. Functional genomics, proteomics, fluxomics, and physiomics are complementary to pathway engineering, and their successful applications are bound to multiply product turnover per cell, channel carbon efficiently, shrink the size of factories (i.e., reduce steel in the ground), and minimize product development cycle times to bring products to market.
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Lactic acid can be obtained either through chemical synthesis or fermentative processes.
“Lactic acid can be obtained either through chemical synthesis or fermentative processes (Chotani et al., 2000).”
From Response surface optimization of D(-)-lactic acid production by Lactobacillus SMI8 using corn steep liquor and yeast autolysate as an alternative nitrogen source (2009) · cites this paper as Chotani et al., 2000
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Importance of systems biology in engineering microbes for biofuel production
Mukhopadhyay, A., Redding, A. M., Rutherford, B. J., & Keasling, J. D. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.05.003 · Cited by 129 · see citing works
Impact of ‘ome’ analyses on inverse metabolic engineering
Bro, C., & Nielsen, J. (2004) · Metabolic Engineering · doi:10.1016/j.ymben.2003.11.005 · Cited by 116 · see citing works
Rawat, G., Tripathi, P., & Saxena, R. K. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4840-y · Cited by 77 · see citing works
Running, J., Severson, D., & Schneider, K. (2002) · Journal of Industrial Microbiology and Biotechnology · doi:10.1038/sj.jim.7000275 · Cited by 58 · see citing works
Cristian, J. B. D. L., Luciana, F. C., Kate, C. B., & Jonas, C. (2009) · African Journal of Biotechnology · doi:10.5897/ajb09.627 · Cited by 46 · see citing works
“Lactic acid can be obtained either through chemical synthesis or fermentative processes (Chotani et al., 2000).”
Background
- Authors
- Chotani, G., Dodge, T., Hsu, A., Kumar, M., LaDuca, R., Trimbur, D., Weyler, W., & Sanford, K.
- Corresponding author
- Sanford, Karl
- Venue
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 1543
- Issue
- 2
- Pages
- 434-455
- ISSN
- 0167-4838 (ISSN-L)
- OpenAlex
- W2134026900
- Cited by
- 234
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 8 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 14 · 2012: 6
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Standards and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- metabolic pathway engineering, fermentation production, functional genomics, proteomics, fluxomics, carbon efficiency, product purity, product development time
- MeSH terms
- Alcohols, Ascorbic Acid, Carboxylic Acids, Chemical Industry, Commerce, Fermentation, Glucose, Hydrocarbons, Aromatic, Models, Chemical, Organic Chemicals, Sugar Acids, Protein Engineering, Genomics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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