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Cited by 116Folate and B Vitamins ResearchDementia and Cognitive Impairment ResearchAlcoholism and Thiamine Deficiency

The DOI matches its Crossref record; 18 of the 20 references it cites were found in a registry or an index.

Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits

Fioravanti, M, Ferrario, E, Massaia, M, Cappa, G, Rivolta, G, Grossi, E, Buckley, A.E·1997·Archives of Gerontology and Geriatrics
DOI 10.1016/s0167-4943(97)00028-9
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Abstract

The relevance of low folate levels as determinants of cognitive deficits and the usefulness of folate supplementation in the treatment of cognitive deficits was reviewed from the literature. Over 40 papers and book chapters published in English, French, German, Italian and Spanish were examined. This represents those papers published in the international literature in the last 10 years which were identified by various key words including folate, cognition and aging (or ageing). Among these papers, only 13 articles specifically addressed issues relevant to the criteria adopted for this review. The remaining papers were principally concerned with depression and or with other pathologies of the aged associated with folate deficiency. Although the specific role of low folate levels in the physiopathology of dementia is still under debate, a growing consensus is emerging in the literature where low folate as well as cobalamin levels in aged patients with cognitive deficits are being considered as a sign of functional problems in the absorption and utilization of vitamins, and not merely as a sign of bad eating habits. In studies where folate compounds were evaluated for treatment effects, the results of a majority of investigations indicated that folate treatment was effective in lessening cognitive deficits. Treatment efficacy, however, has not yet been sufficiently demonstrated by these results because there were no controlled studies and the methodology was heterogeneous for the evaluation of cognitive characteristics. An ad hoc double-blind, controlled versus placebo pilot study was undertaken to evaluate the efficacy of folic acid in 30 aged patients with abnormal cognitive decline and folate level below 3 ng/ml to better understand the value of this type of intervention. Our results from this preliminary study demonstrated that patients treated with folic acid for 60 days showed a significant improvement on both memory and attention efficiency when compared with a placebo group. The intensity of memory improvement was positively correlated with initial severity of folate deficiency. On the contrary, the severity of initial cognitive decline was unrelated to the degree of folate deficiency.

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Research works printed but not linked: 2

  1. Brocker, 1986, Carences en folates chez les sujets agés: intérêt de leur correction dans le traitement des troubles du comportement, Semaine Hop. Paris, 27, 2135
  2. Rapin, 1988, Blood folates deficiencies and cognitive functions in aging, Trends Biomed. Gerontol., 1, 315

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Metadata

Authors
Fioravanti, M., Ferrario, E., Massaia, M., Cappa, G., Rivolta, G., Grossi, E., & Buckley, A. E.
Affiliations
  • Sapienza University of Rome (IT)
  • University of Turin (IT)
  • Bracco (Italy) (IT)
Corresponding author
Buckley, A.E
ORCID
Venue
Archives of Gerontology and Geriatrics
Publisher
Elsevier BV
Published
1997-12
Volume
26
Issue
1
Pages
1-13
ISSN
0167-4943 (ISSN-L)
DOI
10.1016/s0167-4943(97)00028-9
OpenAlex
W2051413962
Cited by
115
References
20
Citations by year
2026: 1 · 2025: 1 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 5
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Gerontology and Geriatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords
folate deficiency, cognitive decline, memory impairment, folic acid supplementation, older adults, aging, dementia, vitamin B12, attention, pilot study

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