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Cited by 31Cardiovascular and exercise physiologyHeart Failure Treatment and ManagementHeart rate and cardiovascular health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Central and peripheral components of chronic heart failure: determinants of exercise tolerance

Florea, Viorel G., Mareyev,, Vyaceslav Yu., Achilov, Abduachat A., Popovici, Mihai I., Coats, Andrew J.S., Belenkov, Yuri N.·1999·International Journal of Cardiology
DOI 10.1016/s0167-5273(99)00047-9
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Abstract

This study sought to determine the relationship between myocardial dysfunction and peripheral haemodynamic disorders to exercise intolerance in patients with chronic heart failure (CHF). Seventeen patients with mild to moderate CHF (peak oxygen consumption (VO2) >16 ml/min/kg) and 13 with severe CHF (peak VO2 <16 ml/min/kg) underwent invasive (Swan-Ganz) cardiopulmonary exercise testing and forearm venous occlusion plethysmography at rest and during maximal dilatation in reactive hyperaemia. There was a shift from central to peripheral haemodynamic factors limiting exercise, suggesting an increasing importance of peripheral factors in parallel to the progression of CHF. In mild to moderate CHF peak VO2 was closely related to central haemodynamics (r = 0.57 for cardiac index at rest; r = 0.76 for cardiac index at maximal workload; r = -0.54 for right arterial pressure at maximal workload; all p<0.05) and poorly correlated with peripheral haemodynamics (blood flow, vascular resistance and venous tone). In contrast, in severe CHF peak VO2 was closely related to peripheral haemodynamic factors (r = 0.79 for forearm blood flow; r = -0.82 for vascular resistance; r = -0.77 for venous tone; all p<0.05) and less to central ones. Thus, exercise tolerance of patients with mild to moderate CHF is predominantly determined by central haemodynamic factors, notably by the cardiac index. In severe CHF peripheral factors assume ever greater importance in the determining of exercise capacity.

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Crossref · 10.1016/s0167-5273(99)00047-9

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29 of 29 references verified0 citation errors · 0 not checkable

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  • Exercise intolerance is due to a combination of central factors such as heart rate and stroke volume as well as peripheral factors including skeletal muscle structure and function.

    “Exercise intolerance is due to a combination of central factors such as heart rate and stroke volume as well as peripheral factors including skeletal muscle structure and function (Figure 2 ), 32 , 33 , 34”

    From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [32]

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Metadata

Authors
Florea, V. G., Mareyev, Achilov, A. A., Popovici, M. I., Coats, A. J. S., & Belenkov, Y. N.
Affiliations
National Medical Research Center of Cardiology (RU)
Corresponding author
Florea, Viorel G.
ORCID
Coats, Andrew J.S.
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
1999-07
Volume
70
Issue
1
Pages
51-56
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/s0167-5273(99)00047-9
OpenAlex
W2067409363
Cited by
31
References
29
Citations by year
2025: 1 · 2022: 2 · 2020: 2 · 2019: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
6.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Society of Cardiology
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords
chronic heart failure, exercise intolerance, exercise capacity, peak oxygen uptake, central hemodynamics, cardiac index, forearm blood flow, vascular resistance, venous tone, cardiac dysfunction, disease severity
MeSH terms
Adult, Cardiac Output, Chronic Disease, Coronary Disease, Forearm, Heart Failure, Hemodynamics, Humans, Male, Middle Aged, Oxygen Consumption, Plethysmography, Regional Blood Flow, Exercise Tolerance, Disease Progression

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