Protective genes expressed in endothelial cells: a regulatory response to injury
Abstract
Endothelial cells (ECs) have evolved to guard against insults that incite inflammation. Response to injury is an active process that, if uncontrolled, can progress to EC death (apoptosis). Here Fritz Bach and colleagues suggest that ECs have a balancing component to their proinflammatory response: they upregulate a set of protective genes, including anti-apoptotic genes, that serve to limit the activation process and thereby regulate the response to injury.
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A20 exerts multiple hepatoprotective functions through combined anti-inflammatory, anti-apoptotic, and pro-proliferative effects in hepatocytes.
“We previously demonstrated that A20/tnfaip3, a key element of the cellular response to injury and inflammation (12, 13), exerts multiple hepatoprotective functions through combined anti-inflammatory, anti-apoptotic, and pro-proliferative effects in hepatocytes (14–16).”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [13]
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A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism
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Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
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Self-citationHeme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
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Coupling Heme and Iron Metabolism <i>via</i> Ferritin H Chain
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Adhesion Molecules in Inflammatory Diseases
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Interferon-γ Acts Directly on Rejecting Renal Allografts to Prevent Graft Necrosis
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- Authors
- Bach, F. H., Hancock, W. W., & Ferran, C.
- Venue
- Immunology Today
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 18
- Issue
- 10
- Pages
- 483-486
- ISSN
- 0167-5699 (ISSN-L)
- OpenAlex
- W2050920255
- Cited by
- 220
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- endothelial cells, protective genes, endothelial injury, anti-apoptotic genes, apoptosis, inflammation, gene expression regulation, endothelial activation
- MeSH terms
- Animals, Endothelium, Graft Rejection, Graft Survival, Humans, Inflammation, Models, Biological, Transplantation, Heterologous, Gene Expression, NF-kappa B, Apoptosis
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