Cited by 104Cell Adhesion Molecules ResearchChemokine receptors and signalingBiochemical and Structural Characterization

Adhesion Molecules in Inflammatory Diseases

Gonz??lez-Amaro, Roberto, D??az-Gonz??lez, Federico, S??nchez-Madrid, Francisco·1998·Drugs

Abstract

Cell adhesion molecules (CAM) have a key role in the inflammatory response. Selectins, integrins and immunoglobulin (Ig) gene superfamily adhesion receptors mediate the different steps of the migration of leucocytes from the blood-stream towards inflammatory foci. The activation of endothelial cells (EC) upregulates the expression of several CAM and triggers the interaction of these cells with leucocytes. Selectins are involved in the initial interactions (tethering/rolling) of leucocytes with activated endothelium, whereas integrins and Ig superfamily CAM mediate the firm adhesion of these cells and their subsequent extravasation. During rolling, leucocytes are activated through the intracellular signals generated by CAM and chemokine receptors. Blockade of the function or expression of CAM has emerged as a new therapeutic target in inflammatory diseases. Different drugs are able to interfere with cell adhesion phenomena. In addition, new antiadhesion therapeutic approaches (blocking monoclonal antibodies, soluble receptors, synthetic peptides, peptidomimetics, etc.) are currently in development.

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Crossref · 10.2165/00003495-199856060-00003

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124 of 124 references verified0 citation errors · 0 not checkable

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Authors
Gonz??lez-Amaro, R., D??az-Gonz??lez, F., & S??nchez-Madrid, F.
Venue
Drugs
Published
1998
Volume
56
Issue
6
Pages
977-988
ISSN
0012-6667 (ISSN-L)
OpenAlex
W2106562180
Cited by
98
References
125
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Drugs (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords
adhesion molecules, inflammation, selectins, integrins, immunoglobulin superfamily receptors, leukocyte migration, leukocyte-endothelium interaction, leukocyte rolling, leukocyte tethering, leukocyte transmigration, endothelial activation, chemokine receptors, anti-adhesion therapy, soluble receptor, peptidomimetics, monoclonal antibodies
MeSH terms
Anti-Inflammatory Agents, Cell Membrane, Humans, Inflammation, Leukocytes, Cell Adhesion Molecules, Up-Regulation, Receptors, Chemokine

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