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Cited by 426Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms

Bager, F, Madsen, M, Christensen, J, Aarestrup, F.M·1997·Preventive Veterinary Medicine
DOI 10.1016/s0167-5877(96)01119-1
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Abstract

We determined the association between the use of the glycopeptide antibiotic avoparcin as a growth promoter and the occurrence of Enterococcus faecium (VREF) with high-level resistance to vancomycin (MIC > or = 64 micrograms ml-1) on poultry and pig farms. The investigations were conducted as retrospective cohort studies, where groups of farms exposed or not exposed to avoparcin between September 1994 and April 1995 were compared. In poultry, the association between the use of avoparcin and the occurrence of VREF was confounded by the use of broad-spectrum antibiotics, and the adjusted relative risk was 2.9 (1.4-5.9). In pigs, the association had a similar magnitude with a non-adjusted relative risk of 3.3 (0.9-12.3). The similar findings in the two studies provide evidence in favour of a causal association between the use of avoparcin and the occurrence of VREF on farms, and suggest that food animals constitute a potential reservoir of infection for VREF in humans.

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Crossref · 10.1016/s0167-5877(96)01119-1

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  1. 1995, EID, 1, 66

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Metadata

Authors
Bager, F., Madsen, M., Christensen, J., & Aarestrup, F. M.
Affiliations
Technical University of Denmark (DK)
Corresponding author
Bager, F
ORCID
Venue
Preventive Veterinary Medicine
Publisher
Elsevier BV
Published
1997-07
Volume
31
Issue
1-2
Pages
95-112
ISSN
0167-5877 (ISSN-L)
DOI
10.1016/s0167-5877(96)01119-1
OpenAlex
W2040630478
Cited by
426
References
34
Citations by year
2026: 3 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 16 · 2013: 20 · 2012: 17
FWCI
8.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Preventive Veterinary Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
avoparcin, growth promoters, vancomycin-resistant Enterococcus faecium, vancomycin resistance, poultry farms, pig farms, antibiotic use, broad-spectrum antibiotics, zoonotic reservoirs, food-producing animals, antimicrobial resistance
MeSH terms
Animals, Anti-Bacterial Agents, Antibodies, Bacterial, Chickens, Denmark, Disease Susceptibility, Drug Resistance, Microbial, Female, Glycopeptides, Growth Substances, Male, Poultry, Poultry Diseases, Retrospective Studies, Specific Pathogen-Free Organisms, Swine, Swine Diseases, Vancomycin, Cohort Studies, Gram-Positive Bacterial Infections, Enterococcus faecium

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