Zopiclone, but not brotizolam, impairs memory storage during sleep
Abstract
We compared the effect of a single bedtime dose of two short half-time hypnotics, brotizolam (0.25 mg) and zopiclone (7.5 mg), on memory storage during sleep in a double blind, placebo-controlled, three-way crossover design trial in eight healthy volunteers. Memory was evaluated using a standard word list free-recall test learned before the bedtime dose by the subjects, who were asked to remember the list the following morning. Digit Symbol Substitution Test revealed no residual sedation by brotizolam or zopiclone. Brotizolam did not affect the morning recall compared to placebo, but subjects remembered less words under zopiclone treatment, suggesting that this drug could affect memory storage during sleep.
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Triazolam and zopiclone administered after learning before sleep impaired retention of words in healthy volunteers.
“Early experiments in healthy volunteers suggested an impairing influence of the benzodiazepine trialzolam and the non-benzodiazepine zopiclone administered after learning before sleep on the retention of words (1040, 1082)”
From About Sleep's Role in Memory (2013) · cites this paper as [1082]
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Dependence on REM Sleep of Overnight Improvement of a Perceptual Skill
Karni, A., Tanne, D., Rubenstein, B. S., Askenasy, J. J. M., & Sagi, D. (1994) · Science · doi:10.1126/science.8036518 · Cited by 1,002 · see citing works
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- Silva, A., Collao, A., Orellana, M., Meléndez, J., Caviedes, P., & Cárdenas, A. M.
- Affiliations
- University of Valparaíso (CL)
- University of Chile (CL)
- Corresponding author
- Cárdenas, Ana M
- Venue
- Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 47
- Issue
- 2
- Pages
- 241-243
- ISSN
- 0168-0102 (ISSN-L)
- OpenAlex
- W1975382606
- Cited by
- 16
- References
- 1
- Citations by year
- 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- zopiclone, brotizolam, hypnotics, sleep-dependent memory consolidation, free recall, word list memory, residual sedation
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Azepines, Double-Blind Method, Female, Humans, Male, Memory, Piperazines, Sleep, Cross-Over Studies, Azabicyclo Compounds
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