Future challenges for drug delivery.
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Unfavorable GC pharmacokinetics can be overcome by a drug delivery system providing slow zero-order release kinetics that keeps plasma drug concentration below toxicity while allowing the drug concentration needed for therapeutic effect.
“This unfavorable pharmacokinetics can be overcome by the use of a drug delivery system (DDS) providing a slow, zero-order release kinetics that, while keeping plasma drug concentration below toxicity level, will allow for the drug concentration needed to achieve a therapeutic effect [5].”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [5]
Cites
Kleinbloesem, C. H., van Brummelen, P., Danhof, M., Faber, H., Urquhart, J., & Breimer, D. D. (1987) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1987.5 · Cited by 178 · see citing works
Self-citationTranslating Safety, Efficacy and Compliance into Economic Value for Controlled Release Dosage Forms
Cramer, M., & Saks, S. R. (1994) · PharmacoEconomics · doi:10.2165/00019053-199405060-00005 · Cited by 85 · see citing works
Wang, W. (1996) · Journal of drug targeting · doi:10.3109/10611869608995624 · Cited by 84 · see citing works
Pulsatile Drug Delivery: Current Applications and Future Trends
Gurny, R., Junginger, H. E., & Peppas, N. A. (1993) · Cited by 61 · see citing works
Mitchell, A. (1996) · Nature · doi:10.1038/384026a0 · Cited by 22 · see citing works
Advances in drug delivery and targeting
Goldstein, D., & Lewis, C. R. (1991) · Current Opinion in Oncology · doi:10.1097/00001622-199112000-00019 · Cited by 10 · see citing works
An Integrated Pharmacokinetic and Pharmacodynamic Approach to Controlled Drug Delivery
Breimer, D. D. (1996) · Journal of drug targeting · doi:10.3109/10611869609015961 · Cited by 10 · see citing works
Self-citationControlled Release Technologies: Current Status and Future Prospects
Guy, R. H., Powell, M., Fix, J. A., & Park, K. (1996) · Pharmaceutical Research · doi:10.1023/a:1016056302529 · Cited by 7 · see citing works
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Cited by
Sorted by citations
Microfabricated drug delivery systems: from particles to pores
Tao, S. L., & Desai, T. A. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00227-2 · Cited by 286 · see citing works
Controlled Rupture of Magnetic Polyelectrolyte Microcapsules for Drug Delivery
Hu, S., Tsai, C.-H., Liao, C.-F., Liu, D., & Chen, S. (2008) · Langmuir · doi:10.1021/la801138e · Cited by 268 · see citing works
Chu, L. (2001) · Journal of Membrane Science · doi:10.1016/s0376-7388(01)00464-1 · Cited by 202 · see citing works
Implantable microchip: the futuristic controlled drug delivery system
Sutradhar, K. B., & Sumi, C. D. (2014) · Drug Delivery · doi:10.3109/10717544.2014.903579 · Cited by 185 · see citing works
Chitosan-Alginate Multilayer Beads for Gastric Passage and Controlled Intestinal Release of Protein
Anal, A. K., Bhopatkar, D., Tokura, S., Tamura, H., & Stevens, W. F. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120021320 · Cited by 176 · see citing works
Preparation of Micron-Sized Monodispersed Thermoresponsive Core−Shell Microcapsules
Chu, L., Park, S.-H., Yamaguchi, T., & Nakao, S. (2002) · Langmuir · doi:10.1021/la011385h · Cited by 160 · see citing works
Leonarduzzi, G., Testa, G., Sottero, B., Gamba, P., & Poli, G. (2009) · Current Medicinal Chemistry · doi:10.2174/092986710789957760 · Cited by 140 · see citing works
Drug Delivery Technologies: The Way Forward in the New Decade
del Valle, E. M. M., Galán, M. Á., & Carbonell, R. G. (2009) · Industrial & Engineering Chemistry Research · doi:10.1021/ie800886m · Cited by 130 · see citing works
A pH‐Responsive Gating Membrane System with Pumping Effects for Improved Controlled Release
Qu, J., Chu, L., Yang, M., Xie, R., Hu, L., & Chen, W. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200500897 · Cited by 106 · see citing works
Drug delivery: an odyssey of 100 years
Pillai, O., Dhanikula, A. B., & Panchagnula, R. (2001) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00226-x · Cited by 102 · see citing works
Nanoengineered device for drug delivery application
Sinha, P. M., Valco, G. J., Sharma, S., Liu, X., & Mauro Ferrari, B. (2004) · Nanotechnology · doi:10.1088/0957-4484/15/10/015 · Cited by 99 · see citing works
Preparation of glucose-sensitive microcapsules with a porous membrane and functional gates
Chu, L., Liang, Y., Chen, W., Ju, X., & Wang, H. (2004) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.06.006 · Cited by 88 · see citing works
Evolving application of biomimetic nanostructured hydroxyapatite
Roveri, N., & Iafisco, M. (2010) · Nanotechnology Science and Applications · doi:10.2147/nsa.s9038 · Cited by 78 · see citing works
Microfabricated Drug Delivery Systems: Concepts to Improve Clinical Benefit
Martin, F. J., & Grove, C. (2001) · Biomedical Microdevices · doi:10.1023/a:1011442024658 · Cited by 78 · see citing works
Ahsan, A., & Farooq, M. A. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101308 · Cited by 75 · see citing works
Yang, W.-C., Xie, R., Pang, X.-Q., Ju, X., & Chu, L. (2008) · Journal of Membrane Science · doi:10.1016/j.memsci.2008.05.016 · Cited by 73 · see citing works
Paolino, D., Sinha, P. M., Fresta, M., & Mauro Ferrari, B. (2006) · Encyclopedia of Medical Devices and Instrumentation · doi:10.1002/0471732877.emd274 · Cited by 73 · see citing works
Avnir, Y., Turjeman, K., Tulchinsky, D., Sigal, A., Kizelsztein, P., Tzemach, D., Gabizon, A., & Barenholz, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025721 · Cited by 72 · see citing works
Kumar, N., Chaubal, M. V., Domb, A. J., & Majeti, R. K. N. V. (2002) · Encyclopedia of Polymer Science and Technology · doi:10.1002/0471440264.pst436 · Cited by 72 · see citing works
Stimuli-responsive Membranes: Smart Tools for Controllable Mass-transfer and Separation Processes
Chu, L., Xie, R., & Ju, X. (2011) · Chinese Journal of Chemical Engineering · doi:10.1016/s1004-9541(11)60070-0 · Cited by 71 · see citing works
Nanotools for the Delivery of Antimicrobial Peptides
Urban, P., Valle‐Delgado, J. J., Moles, E., Marques, J., Diez, C., & Fernàndez‐Busquets, X. (2012) · Current Drug Targets · doi:10.2174/138945012802002302 · Cited by 61 · see citing works
Stimuli-induced Pulsatile or Triggered Release Delivery Systems for Bioactive Compounds
Anal, A. K. (2007) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221407779814598 · Cited by 61 · see citing works
Nanoparticulate devices for brain drug delivery
Celia, C., Cosco, D., Paolino, D., & Fresta, M. (2010) · Medicinal Research Reviews · doi:10.1002/med.20201 · Cited by 57 · see citing works
Release of Biologically Functional Interferon-Alpha from a Nanochannel Delivery System
Lesinski, G. B., Sharma, S., Varker, K. A., Sinha, P. M., Mauro Ferrari, B., & Carson, W. E. (2005) · Biomedical Microdevices · doi:10.1007/s10544-005-6174-8 · Cited by 55 · see citing works
Dual dynamics of promises, and waiting games around emerging nanotechnologies
Parandian, A., Rip, A., & Kulve, H. T. (2012) · Technology Analysis and Strategic Management · doi:10.1080/09537325.2012.693668 · Cited by 52 · see citing works
Innovative Drug Delivery Systems for the Administration of Natural Compounds
Paolino, D., Cosco, D., Cilurzo, F., & Fresta, M. (2007) · Current Bioactive Compounds · doi:10.2174/157340707783220301 · Cited by 52 · see citing works
Sharma, S., Nijdam, A. J., Sinha, P. M., Walczak, R. J., Liu, X., Cheng, M. M., & Mauro Ferrari, B. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.3.379 · Cited by 47 · see citing works
Optimisation of Treatment by Applying Programmable Rate-Controlled Drug Delivery Technology
Chien, Y. W., & Lin, S. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241150-00003 · Cited by 47 · see citing works
Bhopatkar, D., Anal, A. K., & Stevens, W. F. (2005) · Journal of Microencapsulation · doi:10.1080/02652040400026434 · Cited by 42 · see citing works
siRNA Knock-Down of RANK Signaling to Control Osteoclast-Mediated Bone Resorption
Wang, Y., & Grainger, D. W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0099-5 · Cited by 36 · see citing works
El-sherbiny, I. M., Abdel‐Bary, E. M., & Harding, D. R. K. (2009) · Journal of Applied Polymer Science · doi:10.1002/app.30881 · Cited by 28 · see citing works
Anticipatory interventions and the co-evolution of nanotechnology and society
Kulve, H. T. (2011) · doi:10.3990/1.9789036531665 · Cited by 25 · see citing works
Structural and spectroscopic study of tripeptide/layered double hydroxide hybrids
Wang, Y., Wu, P., Li, Y., Zhu, N., & Dang, Z. (2012) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2012.11.031 · Cited by 20 · see citing works
Combinatorial Evaluation of the Host−Guest Chemistry of Star-Shaped Block Copolymers
Meier, M. A. R., & Schubert, U. S. (2005) · Journal of Combinatorial Chemistry · doi:10.1021/cc049824t · Cited by 18 · see citing works
NEED OF COLON SPECIFIC DRUG DELIVERY SYSTEM: REVIEW ON PRIMARY AND NOVEL APPROACHES
Mehta, T. J. (2011) · Cited by 17 · see citing works
Pore Length Effect on Drug Uptake and Delivery by Mesoporous Silicas
Burguete, P., Beltrán, A., Guillem, C., Latorre, J., Pérez‐Pla, F. F., Beltrán, D., & Amorós, P. (2012) · ChemPlusChem · doi:10.1002/cplu.201200099 · Cited by 17 · see citing works
Paradossi, G., Cavalieri, F., & Chiessi, E. (2005) · Carbohydrate Research · doi:10.1016/j.carres.2005.01.023 · Cited by 14 · see citing works
Kidney-Specific Drug Delivery: Review of Opportunities, Achievements, and Challenges
Sarko, D. (2016) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2016.02.00033 · Cited by 13 · see citing works
Nanoporous Implants for Controlled Drug Delivery
Desai, T. A., Sharma, S., Walczak, R. J., Boiarski, A. A., Cohen, M. J., Shapiro, J. P., West, T., Melnik, K., Cosentino, C., Sinha, P. M., et al. (2006) · Springer eBooks · doi:10.1007/978-0-387-25844-7_15 · Cited by 13 · see citing works
Fabrication of Self Assembled Micro Reservoirs for Controlled Drug Release
Pizzi, M., Martiis, O. D., & Grasso, V. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000031753.02913.e2 · Cited by 13 · see citing works
Drug Delivery in the BME Curricula
Saltzman, W. M., & Desai, T. A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9020-5 · Cited by 12 · see citing works
BioMEMS for drug delivery applications
Lewis, J. R., & Mauro Ferrari, B. (2003) · Elsevier eBooks · doi:10.1016/b978-044451100-3/50018-8 · Cited by 12 · see citing works
Controlled‐Release Dosage Forms
Anal, A. K. (2010) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse350 · Cited by 12 · see citing works
Tunable sustained release properties of “onion-like” phospholipids multilamellar vesicles
Douaihy, C. M., Koka, V., Mingotaud, C., & Gauffre, F. (2006) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2006.07.085 · Cited by 11 · see citing works
Rational Design of a Dual-Mode Optical and Chemical Prodrug
McCoy, C. P., Rooney, C., Jones, D. S., Gorman, S. P., & Nieuwenhuyzen, M. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9145-8 · Cited by 10 · see citing works
Economic and societal dimensions of nanotechnology-enabled drug delivery
Kulve, H. T., & Rip, A. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.770467 · Cited by 9 · see citing works
Emerging Techniques and Challenges in Colon Drug Delivery Systems
Singh, G., Kumar, D. K., Singh, M., Sharma, D., & Kaur, S. (2012) · Cited by 8 · see citing works
Vemula, P. K., Campbell, N. R., Zhao, F., Xu, B., John, G., & Karp, J. M. (2011) · Comprehensive Biomaterials · doi:10.1016/b978-0-08-055294-1.00135-5 · Cited by 7 · see citing works
Innovative Formulations for the Controlled and Site-specific Delivery of Antiinflammatory Drugs
Serpe, L., Canaparo, R., Foglietta, F., & Zara, G. P. (2013) · Current Pharmaceutical Design · doi:10.2174/138161281941131219124517 · Cited by 7 · see citing works
Ahmad, H., Khalifeh, I., Alkhalidi, B. A., Aiedeh, K., & AlKhatib, H. S. (2013) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2013.805778 · Cited by 6 · see citing works
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Wang, F., Li, L., & Gao, C. (2009) · Macromolecular Chemistry and Physics · doi:10.1002/macp.200900304 · Cited by 5 · see citing works
Prabhakar, M. N., Song, J., & Rao, K. C. (2015) · Advances in Polymer Technology · doi:10.1002/adv.21517 · Cited by 4 · see citing works
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Sherman, M. C. (2006) · Cited by 4 · see citing works
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Kost, J., Lapidot, S. A., Kumar, N., Chaubal, M. V., Domb, A. J., Kumar, R. R., & Majeti, N. V. (2004) · Kirk-Othmer Encyclopedia of Chemical Technology · doi:10.1002/0471238961.0418210717210104.a01.pub2 · Cited by 3 · see citing works
Rasa, M., Meier, M. A. R., & Schubert, U. S. (2007) · Macromolecular Rapid Communications · doi:10.1002/marc.200700115 · Cited by 2 · see citing works
Preparation of Polyelectrolyte Hydrogels and Study Their Controlled Release of Gabapentin
Haddad, A. M. (2018) · Drug Designing & Intellectual Properties International Journal · doi:10.32474/ddipij.2018.01.000108 · Cited by 2 · see citing works
Recent Advances in Bioresponsive Nanomaterials
Savii, C., & Putz, A.-M. (2011) · Carbon materials: chemistry and physics/Carbon materials · doi:10.1007/978-94-007-1733-6_16 · Cited by 2 · see citing works
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Jat, S. K., & Bhattacharjee, R. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813357-6.00018-8 · Cited by 2 · see citing works
Sacrificial Oxide Layer for Drug Delivery
Sinha, P. M., & Mauro Ferrari, B. (2007) · Springer eBooks · doi:10.1007/978-0-387-25842-3_5 · Cited by 2 · see citing works
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Esentürk‐Güzel, İ., Durgun, M. E., Özsoy, Y., & Güngör, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00143-9 · Cited by 2 · see citing works
Rasool, B. K. A., Ali, I. S. M., & Shahiwala, A. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101701 · Cited by 1 · see citing works
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Chu, L., Xie, R., Ju, X., & Wang, W. (2013) · Springer eBooks · doi:10.1007/978-3-642-39538-3_14 · Cited by 1 · see citing works
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Sravanthi, B., Ahad, H. A., & Sreeramulu, J. (2013) · Cited by 1 · see citing works
Yuan, S., Wu, Q., Lei, F., Li, G., Si, T., & Xu, R. X. (2016) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2212506 · Cited by 1 · see citing works
Chakravarty, P. (2009) · SMARTech Repository (Georgia Institute of Technology) · Cited by 1 · see citing works
Fasinu, P. S. (2010) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg) · Cited by 1 · see citing works
Smart Microcapsules with Thermo-Responsive Gating Membranes
Chu, L. (2011) · Advanced topics in science and technology in China · doi:10.1007/978-3-642-18114-6_3 · Cited by 1 · see citing works
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Urbán, P. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Rv, M., & Shinde, P. V. (2013) · Asian journal of biomedical and pharmaceutical sciences · doi:10.15272/ajbps.v2i15.145
Pv, S., & Rv, M. (2013) · Asian journal of biomedical and pharmaceutical sciences · doi:10.15272/ajbps.v3i17.197
Intracellular drug delivery using laser activated carbon nanoparticles
Sengupta, A. (2014) · SMARTech Repository (Georgia Institute of Technology)
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Mane, A. A., & Jain, A. (2018) · International Journal of Medical & Pharmaceutical Sciences
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Bajpai, S. K., Saggu, S. S., & Bajpai, M. (2016) · Taylor & Francis eBooks · doi:10.1081/e-ebpp-120050563
WYBRANE TECHNOLOGIE OPTYMALIZUJĄCE DOSTARCZANIE SUBSTANCJI CZYNNYCH W NOWOCZESNYCH POSTACIACH LEKU
Gimpel, K., Luliński, P., & Maciejewska, D. (2009) · Prospects in Pharmaceutical Sciences · doi:10.56782/pps.63
pH-Responsive Membranes and Microcapsules for Controlled Release
Chu, L., Xie, R., Ju, X., & Wang, W. (2013) · Springer eBooks · doi:10.1007/978-3-642-39538-3_8
- Authors
- Breimer, D. D.
- Affiliations
- Leiden University (NL)
- Corresponding author
- Breimer, D.D
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 62
- Issue
- 1-2
- Pages
- 3-6
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W1993413788
- Cited by
- 78
- References
- 8
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 9 · 2012: 5
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- drug delivery systems, anti-infective agents, antimicrobial resistance, pharmacokinetics, pharmacodynamics, in vitro drug release, time-kill assay, pharmaceutical dosage forms, bioavailability
- MeSH terms
- Humans, Netherlands, Drug Delivery Systems, Treatment Outcome, Economics, Pharmaceutical
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