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Cited by 514

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

ATP-binding-cassette (ABC) transport systems: Functional and structural aspects of the ATP-hydrolyzing subunits/domains

Open access
Schneider, E·1998·FEMS Microbiology Reviews

Abstract

Members of the superfamily of adenosine triphosphate (ATP)-binding-cassette (ABC) transport systems couple the hydrolysis of ATP to the translocation of solutes across a biological membrane. Recognized by their common modular organization and two sequence motifs that constitute a nucleotide binding fold, ABC transporters are widespread among all living organisms. They accomplish not only the uptake of nutrients in bacteria but are involved in diverse processes, such as signal transduction, protein secretion, drug and antibiotic resistance, antigen presentation, bacterial pathogenesis and sporulation. Moreover, some human inheritable diseases, like cystic fibrosis, adrenoleukodystrophy and Stargardt's disease are caused by defective ABC transport systems. Thus, albeit of major significance, details of the molecular mechanism by which these systems exert their functions are still poorly understood. In this review, recent data concerning the properties and putative role of the ATP-hydrolyzing subunits/domains are summarized and compared between bacterial and eukaryotic systems.

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Metadata

Authors
Schneider, E.
Venue
FEMS Microbiology Reviews
Publisher
Wiley
Published
1998-04
Volume
22
Issue
1
Pages
1-20
ISSN
0168-6445 (ISSN-L)
OpenAlex
W2101254476
Cited by
514
References
3
FWCI
9.85
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: ATP-binding-cassette (ABC) transport systems: Functional and structural aspects of the ATP-hydrolyzing subunits/domains. https://app.cochat.ai/papers/10.1016/s0168-6445(98)00002-3
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Schneider, E. (1998). ATP-binding-cassette (ABC) transport systems: Functional and structural aspects of the ATP-hydrolyzing subunits/domains. FEMS Microbiology Reviews. https://doi.org/10.1016/s0168-6445(98)00002-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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