Cited by 230Suicide and Self-Harm StudiesHepatitis C virus researchTryptophan and brain disorders

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Suicide associated with alfa-interferon therapy for chronic viral hepatitis

Janssen, Harry L.A., Brouwer, Johannes T., van der Mast, Rose C., Schalm, Solko W.·1994·Journal of Hepatology

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Abstract

We report on two attempted suicides and one successful suicide during or shortly after alfa-interferon therapy for chronic viral hepatitis. While on therapy, all three patients developed a psychiatric disorder leading to their suicidal behavior. In a survey of 15 European hospitals, three cases of attempted and two of successful suicide during alfa-interferon therapy for chronic viral hepatitis, were additionally reported. None of the patients had a psychiatric history. Alfa-interferon is known to lead to neuropsychiatric symptoms, and our observations strongly suggest that these mental disorders could lead to suicidal behavior. Therefore it is important that physicians, patients and their families are informed about the potential risk of the emotional and psychiatric disturbances that can occur during alfa-interferon therapy.

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Authors: Janssen, H. L. A., Brouwer, J. T., van der Mast, R. C., & Schalm, S. W.
Affiliations: Academisch Ziekenhuis Rotterdam (NL)
Corresponding author: Schalm, Solko W.
ORCID: Janssen, Harry L.A.
Brouwer, Johannes T.
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 1994-01
Volume: 21
Issue: 2
Pages: 241-243
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/s0168-8278(05)80402-7
OpenAlex: W2158811343
Cited by: 229
References: 11
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 5
FWCI: 6.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: suicide, interferon-alpha, chronic viral hepatitis, psychiatric adverse effects, neuropsychiatric symptoms, suicidal behavior, drug-induced psychiatric disorders, hepatitis C treatment
MeSH terms: Adult, Chronic Disease, Female, Hepatitis, Viral, Human, Humans, Male, Middle Aged, Suicide, Attempted, Interferon-alpha

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Suicide associated with alfa-interferon therapy for chronic viral hepatitis

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