A hot story from comparative genomics: reverse gyrase is the only hyperthermophile-specific protein
Abstract
I have looked for proteins that are present in all hyperthermophile genomes, but absent from all mesophile or thermophile genomes by using the phylogenetic pattern search program of the COG database. Surprisingly, this search retrieved only one such hyperthermophile-specific protein: reverse gyrase. This result emphasizes the importance of reverse gyrase in the adaptation of life to very high temperatures, and strengthens the idea that evolution of this enzyme was crucial in the origin of hyperthermophiles.
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Reverse gyrase is a topoisomerase unique to thermophiles and hyperthermophiles.
“Reverse gyrase is a topoisomerase unique to thermophiles and hyperthermophiles (Forterre 1996;Forterre 2002) that converts closed, circular DNA to a positively supercoiled form (Kikuchi and Asai 1984).”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Forterre 2002
Reverse gyrase is critical to hyperthermophilic life.
“Reverse gyrase is critical to hyperthermophilic life (Forterre 1996;Forterre 2002;Kikuchi and Asai 1984;Heine and Chandra 2009).”
From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Forterre 2002
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Mirkin, B. G., Fenner, T. I., Galperin, M. Y., & Koonin, E. V. (2003) · BMC Evolutionary Biology · doi:10.1186/1471-2148-3-2 · Cited by 368 · see citing works
The origin of DNA genomes and DNA replication proteins
Forterre, P. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00360-0 · Cited by 190 · see citing works
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Self-citationEnvironmental Adaptation from the Origin of Life to the Last Universal Common Ancestor
Cantine, M. D., & Fournier, G. P. (2018) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-017-9542-5 · Cited by 54 · see citing works
Hyperthermophily and the origin and earliest evolution of life
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- Authors
- Forterre, P.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Forterre, Patrick
- ORCID
- Forterre, Patrick
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 18
- Issue
- 5
- Pages
- 236-237
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2023218781
- Cited by
- 228
- References
- 12
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 15 · 2013: 13 · 2012: 5
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- reverse gyrase, hyperthermophiles, comparative genomics, protein evolution, thermal adaptation, mesophiles, thermophiles
- MeSH terms
- Archaea, Bacteria, DNA Topoisomerases, Type I, Hot Temperature, Species Specificity, Genome, Bacterial, Genome, Archaeal
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