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Cited by 24Heat shock proteins researchNeurological Disease Mechanisms and TreatmentsCardiac Ischemia and Reperfusion

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Suppression subtraction hybridization and northern analysis reveal upregulation of heat shock, trkB, and sodium calcium exchanger genes following global cerebral ischemia in the rat

Majda, Bernadette T, Meloni, Bruno P, Rixon, Nerida, Knuckey, Neville W·2001·Molecular Brain Research
DOI 10.1016/s0169-328x(01)00203-0
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Abstract

Driver (sham-operated) and tester (ischemic) hippocampal cDNAs were subtracted, and the resulting ischemia-induced upregulated gene expression was verified by northern analysis. cDNAs isolated corresponded to (1) genes known to be upregulated following ischemia, (hsc70, hsp90, hsp105 and trkB) and (2) a gene not previously implicated with cerebral ischemia, sodium calcium exchanger (ncx). Furthermore, upregulation of these genes was demonstrated following preconditioning transient global ischemia.

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Research works printed but not linked: 35

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Metadata

Authors
Majda, B. T., Meloni, B. P., Rixon, N., & Knuckey, N. W.
Affiliations
  • The University of Western Australia (AU)
  • Murdoch University (AU)
Corresponding author
Knuckey, Neville W
ORCID
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
2001-09
Volume
93
Issue
2
Pages
173-179
ISSN
0169-328X (ISSN-L)
DOI
10.1016/s0169-328x(01)00203-0
OpenAlex
W2062024525
Cited by
24
References
0
Citations by year
2025: 1 · 2024: 1 · 2016: 1 · 2014: 1 · 2013: 2
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords
global cerebral ischemia, heat shock proteins, Hsc70, HSP90, HSP105, TrkB, Na+/Ca2+ exchanger, hippocampus, preconditioning, transient global cerebral ischemia, gene expression
MeSH terms
Animals, Brain Ischemia, Ischemic Attack, Transient, Gene Expression Regulation, Heat-Shock Proteins, Hippocampus, Male, Nerve Tissue Proteins, Subtraction Technique, Blotting, Northern, Up-Regulation, Rats, Sprague-Dawley, DNA, Complementary, Sodium-Calcium Exchanger, Receptor, trkB, Gene Expression Profiling, Rats

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