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The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

Klein, Rüdiger, Conway, Dorothy, Parada, Luis F., Barbacid, Mariano·1990·Cell
DOI 10.1016/0092-8674(90)90476-u
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Abstract

We previously identified two tyrosine protein kinase genes, designated trk and trkB, that code for putative neurogenic cell surface receptors. In this study, we report that the mouse trkB locus codes for at least two classes of receptor-like molecules. These trkB proteins, designated gp145trkB and gp95trkB, have identical extracellular and transmembrane domains, suggesting that they might recognize the same ligand(s). However, only gp145trkB contains a long cytoplasmic region, which includes a catalytic tyrosine protein kinase domain. trkB transcripts coding for this protein were observed in the cerebral cortex and the pyramidal cell layer of the hippocampus. In contrast, transcripts coding for the noncatalytic gp95trkB molecule were found in the ependymal linings of the cerebral ventricles and in the choroid plexus. These results illustrate that a tyrosine protein kinase locus can code for two structurally and functionally distinct cellular receptors.

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  • Both TrkB-FL and TrkB.T1 receptors are expressed in neurons because of alternative splicing; TrkB.T1 lacks the kinase domain but contains a short isoform-specific cytoplasmic domain.

    “Both full-length TrkB (TrkB-FL) and its isoform T1 (TrkB.T1) receptors, which lack the kinase domain but contain short isoform-specific cytoplasmic domain in its place, are expressed in neurons because of alternative splicing (Klein et al., 1990).”

    From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Klein et al., 1990

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Research works printed but not linked: 19

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Metadata

Authors
Klein, R., Conway, D., Parada, L. F., & Barbacid, M.
Venue
Cell
Publisher
Elsevier BV
Published
1990-05
Volume
61
Issue
4
Pages
647-656
ISSN
0092-8674
DOI
10.1016/0092-8674(90)90476-u
Cited by
590
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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