The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures
Abstract
We have previously shown that IL-6 protein levels are increased in cerebrospinal fluid in humans after recent tonic-clonic seizures with unchanged levels of IL-1beta and TNFalpha. Here we studied the expression of cytokines IL-6, LIF, IL-1beta and TNFalpha and cytokine receptors IL-6R, LIFR and Gp130 in the rat brain after kainic acid-induced status epilepticus using Northern blot analysis and in situ hybridization histochemistry. After seizures, IL-6 mRNA was induced in the hippocampus, cortex, amygdala and meninges, and IL-6R was up-regulated in the hippocampus. LIF was up-regulated in the hippocampus, cortex and meninges after seizures, and LIFR mRNA was induced in the hippocampus and cortex. Gp130 was constitutively expressed in the brain. After seizures, Gp130 transcription was rapidly induced in the meninges. In thalamus, cortex, amygdala and hippocampus Gp130 mRNA was induced in a delayed fashion. IL-1beta transcription was induced in the temporal lobe cortex and thalamus, and TNFalpha in the hippocampus. In general, the cytokine and their receptor mRNA levels were low in intact rat brain, but were induced by seizures. Since IL-6 and LIF transcripts were induced in the meninges after seizures, the protein products of these transcripts may be more readily released in cerebrospinal fluid after seizures. In addition, the activity of IL-6 and LIF signaling pathways may be influenced by increased expression of their receptors after seizures.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies in animal models have reported that seizures are associated with increased activation of microglia, especially of the M1 subtype [189], and an increased release of pro-inflammatory mediators [190, 191].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [190]
Citations
Cites
pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin
Danielson, P. E., Forss‐Petter, S., Brow, M. A. D., Calavetta, L., DOUGLASS, J. O., Milner, R. J., & Sutcliffe, J. G. (1988) · DNA · doi:10.1089/dna.1988.7.261 · Cited by 1,020
Bruce‐Keller, A. J., Boling, W., Kindy, M. S., Peschon, J. J., Kraemer, P. J., Carpenter, M. K., Holtsberg, F. W., & Mattson, M. P. (1996) · Nature Medicine · doi:10.1038/nm0796-788 · Cited by 934
Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke
Vila, N., Castillo, J., Dávalos, A., & Chamorro, Á. (2000) · Stroke · doi:10.1161/01.str.31.10.2325 · Cited by 676
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
Jostock, T., Müllberg, J., Özbek, S., Atreya, R., Blinn, G., Voltz, N., Fischer, M., Neurath, M., & Rose-John, S. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01867.x · Cited by 665
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N., & Fuller, G. M. (2001) · The FASEB Journal · doi:10.1096/fj.99-1003rev · Cited by 628
Vezzani, A., Conti, M., Luigi, A. D., Ravizza, T., Moneta, D., Marchesi, F., & Simoni, M. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05054.1999 · Cited by 603
Kainic acid induced seizures: Neurochemical and histopathological changes
Sperk, G., Lassmann, H., Baran, H., Kish, S. J., SEITELBERGER, F., & Hornykiewicz, O. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90113-6 · Cited by 529
Simoni, M. G. D., Perego, C., Ravizza, T., Moneta, D., Conti, M., Marchesi, F., Luigi, A. D., Garattini, S. K., & Vezzani, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00140.x · Cited by 511
A neuromodulatory role of interleukin-1β in the hippocampus
Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498
Interleukin-6 (IL-6)—A molecule with both beneficial and destructive potentials
Gadient, R. A., & Otten, U. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00021-x · Cited by 481
Cited by
Sorted by citations
Brain Inflammation in Epilepsy: Experimental and Clinical Evidence
Vezzani, A., & Granata, T. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00298.x · Cited by 1,049
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750
The role of cytokines in the pathophysiology of epilepsy
Vezzani, A., Balosso, S., & Ravizza, T. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.03.009 · Cited by 564
Immune–neural connections: how the immune system’s response to infectious agents influences behavior
McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429
Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress‐Induced Diseases and Aging
Chen, C.-Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3571614 · Cited by 369
Metadata
- Authors
- Lehtimäki, K. A., Peltola, J., Koskikallio, E., Keränen, T., & Honkaniemi, J.
- Affiliations
- Tampere University Hospital (FI)
- Corresponding author
- Honkaniemi, J
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 110
- Issue
- 2
- Pages
- 253-260
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1995444099
- Cited by
- 163
- References
- 49
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 16 · 2013: 8 · 2012: 5
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Tampere University Institutional Repository (Tampere University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- cytokines, cytokine receptors, kainic acid-induced seizures, status epilepticus, interleukin-6, leukemia inhibitory factor, IL-6 receptor, LIF receptor, gp130, IL-1β, TNF-α, hippocampus, meninges, cerebrospinal fluid, neuroinflammation, rat brain
- MeSH terms
- Animals, Brain, Epilepsy, Gene Expression Regulation, Growth Inhibitors, Interleukin-1, Lymphokines, Male, Neurons, RNA, Messenger, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Rats, Sprague-Dawley, Receptors, Cytokine, Neural Cell Adhesion Molecules, Receptors, Interleukin-6, Rats, Leukemia Inhibitory Factor, Receptors, OSM-LIF, Leukemia Inhibitory Factor Receptor alpha Subunit, Contactins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
