Immune–neural connections: how the immune system’s response to infectious agents influences behavior

From inflammation to sickness and depression: when the immune system subjugates the brain

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Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works

Signaling in innate immunity and inflammation

Newton, K., & Dixit, V. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006049 · Cited by 1,513 · see citing works

Immune modulation of learning, memory, neural plasticity and neurogenesis

Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works

Control of Synaptic Strength by Glial TNFα

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Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

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Cytokine-induced sickness behavior: where do we stand?

Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works

Brain-immune communication pathways

Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626 · see citing works

TNF receptor subtype signalling: Differences and cellular consequences

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Endotoxin produces a depressive-like episode in rats

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Is depression an inflammatory disorder?

Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

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Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

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Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management

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The Structure and Function of the Eukaryotic RibosomePreprint

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Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

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Toxoplasma Profilin Is Essential for Host Cell Invasion and TLR11-Dependent Induction of an Interleukin-12 Response

Plattner, F., Yarovinsky, F., Romero, S., Didry, D., Carlier, M., Sher, A., & Soldati‐Favre, D. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.01.001 · Cited by 384 · see citing works

Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression

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Cytokine, sickness behavior, and depression

Dantzer, R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.003 · Cited by 340 · see citing works

Tumor necrosis factor alters synaptic transmission in rat hippocampal slices.

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The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)

Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.007 · Cited by 318 · see citing works

Depressive-like behavior induced by tumor necrosis factor-α in mice

Kaster, M. P., Gadotti, V. M., Calixto, J. B., Santos, A. R. S., & Rodrigues, A. L. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.018 · Cited by 294 · see citing works

Neurocircuitry of illness-induced hyperalgesia

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Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice

Bluthé, R.-M., Layé, S., Michaud, B., Combe, C., Dantzer, R., & Parnet, P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.01348.x · Cited by 283 · see citing works

Flagellin, a Novel Mediator of Salmonella -Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction

Eaves-Pyles, T. D., Murthy, K. G. K., Liaudet, L., Virág, L., Ross, G. F., Soriano, F. G., Szabó, C., & Salzman, A. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1248 · Cited by 270 · see citing works

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

Furukawa, K., & Mattson, M. P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051876.x · Cited by 254 · see citing works

Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling

Guan, Y., Rañoa, D. R. E., Jiang, S., Mutha, S. K., Li, X., Baudry, J. Y., & Tapping, R. I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901888 · Cited by 252 · see citing works

TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting

Simen, B. B., Duman, C. H., Simen, A. A., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.013 · Cited by 249 · see citing works

IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors

Chourbaji, S., Urani, A., Inta, I., Sanchis-Segura, C., Brandwein, C., Zink, M., Schwaninger, M., & Gass, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.001 · Cited by 241 · see citing works

Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice.

Bluthé, R., Michaud, B., Poli, V., & Dantzer, R. (2000) · Physiology and Behavior · doi:10.1016/s0031-9384(00)00269-9 · Cited by 239 · see citing works

Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy

Capuron, L., Ravaud, A., Miller, A. H., & Dantzer, R. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.004 · Cited by 237 · see citing works

Effect of cytokines on neuronal excitability

Schäfers, M., & Sorkin, L. S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.052 · Cited by 224 · see citing works

Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism

Bret-Dibat, J. L., Bluthé, R.-M., Kent, S., KELLEY, K. W., & Dantzer, R. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1023 · Cited by 224 · see citing works

The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus

Ida-Hosonuma, M., Iwasaki, T., Yoshikawa, T., Nagata, N., Sato, Y., Sata, T., Yoneyama, M., Fujita, T., Taya, C., Yonekawa, H., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.4460-4469.2005 · Cited by 219 · see citing works

Inflammatory mechanisms in major depressive disorder

Raedler, T. J. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834b9db6 · Cited by 213 · see citing works

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

Field, R. H., Campion, S., Warren, C., Murray, C., & Cunningham, C. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.004 · Cited by 209 · see citing works

Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice

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Cytokines and Neuronal Ion Channels in Health and Disease

Viviani, B., Gardoni, F., & Marinovich, M. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82013-7 · Cited by 195 · see citing works

Tumor necrosis factor‐α‐induced neutral sphingomyelinase‐2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

Wheeler, D., Knapp, E., Bandaru, V. V. R., Wang, Y., Knorr, D., Poirier, C., Mattson, M. P., Geiger, J. D., & Haughey, N. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06038.x · Cited by 194 · see citing works

Cell Type-Specific Interleukin-1β Signaling in the CNS

Srinivasan, D., Yen, J.-H. J., Joseph, D. J., & Friedman, W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5712-03.2004 · Cited by 192 · see citing works

The role of IFN-γ in immune responses to viral infections of the central nervous system

Chesler, D. A., & Reiss, C. S. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00044-8 · Cited by 182 · see citing works

Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes

Bluthé, R.-M., Michaud, B., Kelley, K. W., & Dantzer, R. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00083 · Cited by 171 · see citing works

Pattern recognition receptors in the immune response against dying cells

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Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures

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Identification of a high-affinity receptor for interleukin-1 beta in rat brain

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Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally

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Genetic deletion or pharmacological inhibition of cyclooxygenase‐1 attenuate lipopolysaccharide‐ induced inflammatory response and brain injury

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Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice

Park, S.-E., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-12 · Cited by 157 · see citing works

Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior

Harden, L. M., du Plessis, I., Poole, S., & Laburn, H. P. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.016 · Cited by 155 · see citing works

Differential induction of c-Fos immunoreactivity in hypothalamus and brain stem nuclei following central and peripheral administration of endotoxin

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A neurohistochemical blueprint for pain-induced loss of appetite

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Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines

Teeling, J. L., Felton, L. M., Deacon, R. M. J., Cunningham, C. M., Rawlins, J. N. P., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.01.012 · Cited by 140 · see citing works

The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1

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Innate responses to Toxoplasma gondii in mice and humans

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Prostaglandins and sickness behavior: Old story, new insights

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Central nervous action of interleukin‐1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide

Konsman, J. P., Veeneman, J., Combe, C., Poole, S., Luheshi, G. N., & Dantzer, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06549.x · Cited by 132 · see citing works

Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior

Burton, M. D., Sparkman, N. L., & Johnson, R. W. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-54 · Cited by 127 · see citing works

Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats

Lenczowski, M. J. P., Bluthé, R.-M., Roth, J., Rees, G. S., Rushforth, D. A., van Dam, A., Tilders, F. J. H., Dantzer, R., Rothwell, N. J., & Luheshi, G. N. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.3.r652 · Cited by 117 · see citing works

Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice

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Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: Circulating and brain cytokines, plasma corticosterone and behavioral changes in mice

Gibb, J., Hayley, S. P., Gandhi, R., Poulter, M. O., & Anisman, H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.12.001 · Cited by 111 · see citing works

Tracing the development of psychosis and its prevention: what can be learned from animal models

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Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice

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Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats

Luheshi, G. N., Bluthé, R.-M., Rushforth, D. A., MULCAHY, N., Konsman, J. P., Goldbach, M., & Dantzer, R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00231-9 · Cited by 106 · see citing works

Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-α mRNA in rats: a model for immunologically induced fatigue

Katafuchi, T., Kondo, T., Yasaka, T., Kubo, K., Take, S., & Yoshimura, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00365-8 · Cited by 105 · see citing works

Type I interferon response in the central nervous system

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Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: Moderation by social stressors

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Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice

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Influence of continuous infusion of interleukin-1β on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression

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Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice

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Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

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Enhanced expression of brain interferon‐α and serotonin transporter in immunologically induced fatigue in rats

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Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1β or tumor necrosis factor α

Churchill, L., Taishi, P., Wang, M., Brandt, J. A., Cearley, C. N., Rehman, A., & Krueger, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.083 · Cited by 76 · see citing works

IL‐1 β , TNF α and IL‐6 induction in the rat brain after partial‐body irradiation: role of vagal afferents

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IL‐1β induces a MyD88‐dependent and ceramide‐mediated activation of Src in anterior hypothalamic neurons

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Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

Park, S.-E., Lawson, M. A., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-179 · Cited by 65 · see citing works

Differences in the relative involvement of peripherally released interleukin (IL)-6, brain IL-1β and prostanoids in mediating lipopolysaccharide-induced fever and sickness behavior

Harden, L. M., du Plessis, I., Roth, J., Loram, L. C., Poole, S., & Laburn, H. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.003 · Cited by 64 · see citing works

Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I:C in Mice

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Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever

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Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression

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Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2?

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TNFα-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I

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Intracellular sensors of extracellular bacteria

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Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1

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Constitutive expression of p55TNFR mRNA and mitogen‐specific up‐regulation of TNFα and p75TNFR mRNA in mouse brain

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Peripheral challenge with double‐stranded RNA elicits global up‐regulation of cytokine gene expression in the brain

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