Cited by 236Advanced Drug Delivery SystemsGlycosylation and Glycoproteins ResearchInhalation and Respiratory Drug Delivery

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Lectin-mediated mucosal delivery of drugs and microparticles

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Clark, M.Ann, Hirst, Barry H, Jepson, Mark A·2000·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(00)00070-3

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Abstract

Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell- and site-selective targeting. One approach is to exploit surface carbohydrates on mucosal epithelial cells for lectin-mediated delivery. We review work supporting the use of lectins as mucosal bioadhesins in the gastrointestinal and respiratory tracts, the oral cavity and the eye. The gastrointestinal tract is particularly favoured for mucosal delivery. Many studies have demonstrated that the antigen sampling intestinal M cells offer a portal for absorption of colloidal delivery vehicles. Evidence is presented that M cell targeting may be achieved using M cell-specific lectins, microbial adhesins or immunoglobulins. While many hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this is an exciting area of research that has important implications for future drug and vaccine formulation.

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Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size
Desai, M. P., Labhasetwar, V. D., Amidon, G. L., & Levy, R. J. (1996) · Pharmaceutical Research · doi:10.1023/a:1016085108889 · Cited by 942
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
Jani, P., Halbert, G. W., Langridge, J., & Florence, A. T. (1990) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1990.tb07033.x · Cited by 920
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.
Jones, B. D., Ghori, N., & Falkow, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.15 · Cited by 883
Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
Isberg, R. R., & Leong, J. M. (1990) · Cell · doi:10.1016/0092-8674(90)90099-z · Cited by 798
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
Eldridge, J. H., Hammond, C., Meulbroek, J. A., Staas, J. K., Gilley, R. M., & Tice, T. R. (1990) · Journal of Controlled Release · doi:10.1016/0168-3659(90)90133-e · Cited by 689
Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria
Kernéis, S. M., Bogdanova, A. A., Kraehenbühl, J.-P., & Pringault, E. (1997) · Science · doi:10.1126/science.277.5328.949 · Cited by 630
Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
Isberg, R. R., Voorhis, D. L., & Falkow, S. (1987) · Cell · doi:10.1016/0092-8674(87)90335-7 · Cited by 597
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
Florence, A. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012029517394 · Cited by 498
Intestinal M Cells: A Pathway for Entry of Reovirus into the Host
Wolf, J. L., Rubin, D. H., Finberg, R. W., Kauffman, R. S., Sharpe, A. H., Trier, J. S., & Fields, B. N. (1981) · Science · doi:10.1126/science.6259737 · Cited by 483
Immune responses to dietary antigens: oral tolerance
Ströbel, S., & Mowat, A. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01239-5 · Cited by 454
Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research · doi:10.1023/a:1011922819926 · Cited by 402
Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting
Frey, A., Giannasca, K. T., Weltzin, R., Giannasca, P. J., Reggio, H., Lencer, W. I., & Neutra, M. R. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1045 · Cited by 401
The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
Jani, P. U., Halbert, G., Langridge, J., & Florence, A. T. (1989) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1989.tb06377.x · Cited by 394
M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells
Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1237-1243.1998 · Cited by 366
Self-citation
Immunology of the tonsils
Perry, M. E., & Whyte, A. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01307-3 · Cited by 347
M Cells in Peyer's Patches of the Intestine
Gebert, A., Rothkötter, H., & Pabst, R. (1996) · International review of cytology · doi:10.1016/s0074-7696(08)61346-7 · Cited by 319
Protein σ1 is the reovirus cell attachment protein
Lee, P. W. K., Hayes, E. C., & Joklik, W. K. (1981) · Virology · doi:10.1016/0042-6822(81)90535-3 · Cited by 298
Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera.
Bland, P. W., & Warren, L. G. (1986) · PubMed · Cited by 290
The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches.
Bäumler, A. J., Tsolis, R. M., & Heffron, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.279 · Cited by 288
Lectin-carbohydrate complexes of plants and animals: an atomic view
Sharon, N. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90193-q · Cited by 282
M cells as ports of entry for enteroinvasive pathogens: Mechanisms of interaction, consequences for the disease process
Sansonetti, P. J., & Phalipon, A. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0175 · Cited by 269
Binding and uptake of biodegradable poly-dl-lactide micro- and nanoparticles in intestinal epithelia
McClean, S., Prosser, E. S., Meehan, E., O'Malley, D., Clarke, N., Ramtoola, Z., & Brayden, D. J. (1998) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(97)10007-0 · Cited by 259
New strategies for using mucosal vaccination to achieve more effective immunization
Walker, R. I. (1994) · Vaccine · doi:10.1016/0264-410x(94)90112-0 · Cited by 257
Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.
Bland, P. W., & Warren, L. G. (1986) · PubMed · Cited by 252
Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces
Haneberg, B., Kendall, D., Amerongen, H. M., Apter, F. M., Kraehenbühl, J. P., & Neutra, M. R. (1994) · Infection and Immunity · doi:10.1128/iai.62.1.15-23.1994 · Cited by 248
Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein.
Leong, J. M., Fournier, R., & Isberg, R. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08326.x · Cited by 241
Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells
Clark, M. A., Jepson, M. A., Simmons, N. L., & Hirst, B. H. (1994) · Research in Microbiology · doi:10.1016/0923-2508(94)90031-0 · Cited by 235
Self-citation
Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins.
Weltzin, R., Lucia-Jandris, P., Michetti, P., Fields, B. N., Kraehenbuhl, J. P., & Neutra, M. R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.5.1673 · Cited by 230
Differential expression of lectin-binding sites defines mouse intestinal M-cells.
Clark, M. A., Jepson, M. A., Simmons, N. L., Booth, T. A., & Hirst, B. H. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.11.7691933 · Cited by 221
Self-citation
Poliovirus type 1 enters the human host through intestinal M cells
Siciński, P., Rowiński, J., Warchoł, J. B., Jarzabek, Z., Gut, W., Szczygieł, B., Bielecki, K., & Koch, G. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91290-m · Cited by 215
Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium
Marra, A., & Isberg, R. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3412-3421.1997 · Cited by 214
An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
Lehr, C., Poelma, F. G. J., Junginger, H. E., & Tukker, J. J. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90287-x · Cited by 212
Penetration of M cells and destruction of Peyer's patches by Yersinia enterocolitica: an ultrastructural and histological study
Autenrieth, I. B., & Firsching, R. (1996) · Journal of Medical Microbiology · doi:10.1099/00222615-44-4-285 · Cited by 197
Enhanced Oral Uptake of Tomato Lectin-Conjugated Nanoparticles in the Rat
Hussain, N., Jani, P. U., & Florence, A. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012153011884 · Cited by 190
Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers
Chen, H., Torchilin, V. P., & Langer, R. (1996) · Pharmaceutical Research · doi:10.1023/a:1016030202104 · Cited by 186
Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine
Wolf, J. L., Kauffman, R. S., Finberg, R. W., Dambrauskas, R., Fields, B. N., & Trier, J. S. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90313-x · Cited by 186
Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine
Beaulieu, J. (1992) · Journal of Cell Science · doi:10.1242/jcs.102.3.427 · Cited by 179
Nasal lymphoid tissue in the rat
Spit, B. J., Hendriksen, E. G. J., Bruijntjes, J. P., & Kuper, C. F. (1989) · Cell and Tissue Research · doi:10.1007/bf00229081 · Cited by 157
The invasin protein of Yersinia enterocolitica: internalization of invasin-bearing bacteria by eukaryotic cells is associated with reorganization of the cytoskeleton.
Young, V. B., Falkow, S., & Schoolnik, G. K. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.1.197 · Cited by 156
Human Intestinal M Cells Display the Sialyl Lewis A Antigen
Giannasca, P. J., Giannasca, K. T., Leichtner, A. M., & Neutra, M. R. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.946-953.1999 · Cited by 155
Factors Affecting the Oral Uptake and Translocation of Polystyrene Nanoparticles: Histological and Analytical Evidence
Florence, A. T., Hillery, A. M., Hussain, N., & Jani, P. U. (1995) · Journal of drug targeting · doi:10.3109/10611869509015936 · Cited by 154
Regional differences in glycoconjugates of intestinal M cells in mice: potential targets for mucosal vaccines
Giannasca, P. J., Giannasca, K. T., Falk, P., Gordon, J. I., & Neutra, M. R. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.6.g1108 · Cited by 154
Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo
Foster, N. M. (1998) · Vaccine · doi:10.1016/s0264-410x(97)00222-3 · Cited by 146
Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract.
Lehr, C. (1994) · PubMed · Cited by 145
Engineering poliovirus as a vaccine vector for the expression of diverse antigens
Andino, R., Silvera, D., Suggett, S., Achacoso, P., Miller, C. J., Baltimore, D., & Feinberg, M. B. (1994) · Science · doi:10.1126/science.8073288 · Cited by 142
Vaccine-Containing Biodegradable Microspheres Specifically Enter the Gut-Associated Lymphoid Tissue Following Oral Administration and Induce a Disseminated Mucosal Immune Response
Eldridge, J. H., Meulbroek, J. A., Staas, J. K., Tice, T. R., & Gilley, R. M. (1989) · Springer eBooks · doi:10.1007/978-1-4757-2046-4_18 · Cited by 133
Targeting to intestinal M cells.
Jepson, M. A., Clark, M. A., Foster, N. M., Mason, C. M., Bennett, M. K., Simmons, N. L., & Hirst, B. H. (1996) · Europe PMC (PubMed Central) · Cited by 133
Self-citation
Studying M cells and their role in infection
Jepson, M. A., & Clark, M. A. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01337-7 · Cited by 129
Self-citation
Bioadhesion by Means of Specific Binding of Tomato Lectin
Lehr, C., Bouwstra, J. A., Kok, W., Noach, A. B. J., de Boer, A. G., & Junginger, H. E. (1992) · Pharmaceutical Research · doi:10.1023/a:1015804816582 · Cited by 122
Nasal Delivery of Vaccines
Almeida, A. J., & Alpar, H. O. (1996) · Journal of drug targeting · doi:10.3109/10611869609015965 · Cited by 117
Lectin-mediated transport of nanoparticles across Caco-2 and OK cells
Russell-Jones, G. J., Veitch, H. S., & Arthur, L. M. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00254-9 · Cited by 116
The composition and function of M cell apical membranes: Implications for microbial pathogenesis
Neutra, M. R., Mantis, N. J., Frey, A., & Giannasca, P. J. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0173 · Cited by 116
Tomato lectin resists digestion in the mammalian alimentary canal and binds to intestinal villi without deleterious effects
Kilpatrick, D. C., Pusztai, A. J., Grant, G., Graham, C., & Ewen, S. W. B. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80927-3 · Cited by 114
Proteolytic processing of reovirus is required for adherence to intestinal M cells
Amerongen, H. M., Wilson, G. A. R., Fields, B. N., & Neutra, M. R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8428-8432.1994 · Cited by 108
Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells
Jepson, M. A., Simmons, N. L., Savidge, T., James, P. S., & Hirst, B. H. (1993) · Cell and Tissue Research · doi:10.1007/bf02913722 · Cited by 108
Self-citation
Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum
Pascopella, L., Raupach, B., Ghori, N., Monack, D. M., Falkow, S., & Small, P. L. C. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4329-4335.1995 · Cited by 106
Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells.
Pappo, J., Ermak, T. H., & Steger, H. J. (1991) · PubMed Central · Cited by 101
Comparison of Poly(dl-Lactide-co-glycolide) and Polystyrene Microsphere Targeting to Intestinal M Cells
Jepson, M. A., Simmons, N. L., O’Hagan, D. T., & Hirst, B. H. (2003) · Journal of drug targeting · doi:10.1080/10611860310001636502 · Cited by 101
Self-citation
M cells at locations outside the gut
Gebert, A., & Pabst, R. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0172 · Cited by 97
Utilizing Bacterial Mechanisms of Epithelial Cell Entry: Invasin-induced Oral Uptake of Latex Nanoparticles
Hussain, N., & Florence, A. T. (1998) · Pharmaceutical Research · doi:10.1023/a:1011981610840 · Cited by 94
The Development of M Cells in Peyer's Patches Is Restricted to Specialized Dome-Associated Crypts
Gebert, A., Fassbender, S., Werner, K., & Weissferdt, A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65410-7 · Cited by 92
Selective transport of microparticles across Peyer's patch follicle‐associated M cells from mice and rats
Mw, S., Thomas, N., Jenkins, P., Miller, N., Cremaschi, D., & Porta, C. (1995) · Experimental Physiology · doi:10.1113/expphysiol.1995.sp003882 · Cited by 92
Comparison of Poly(DL-Lactide-co-Glycolide) and Polystyrene Microsphere Targeting to Intestinal M Cells
Jepson, M. A., Simmons, N. L., O’Hagan, D. T., & Hirst, B. H. (1993) · Journal of drug targeting · doi:10.3109/10611869308996082 · Cited by 91
Self-citation
Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes
Zhou, F. (1995) · Vaccine · doi:10.1016/0264-410x(94)00029-m · Cited by 89
Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins
Giannasca, P. J., Boden, J. A., & Monath, T. P. C. (1997) · Infection and Immunity · doi:10.1128/iai.65.10.4288-4298.1997 · Cited by 89
Selective binding and transcytosis of Ulex europaeus 1 lectin by mouse Peyer's patch M-cells in vivo
Clark, M. A., Jepson, M. A., Simmons, N. L., & Hirst, B. H. (1995) · Cell and Tissue Research · doi:10.1007/bf00318877 · Cited by 88
Self-citation
Lectin binding reveals divergent carbohydrate expression in human and mouse Peyer's patches
Sharma, R. P., Damme, E. J. M. V., Peumans, W. J., Sarsfield, P., & Schumacher, U. (1996) · Histochemistry and Cell Biology · doi:10.1007/bf01457659 · Cited by 84
Development of dome epithelium in gut-associated lymphoid tissues: Association of IgA with M cells
Roy, M., & Varvayanis, M. (1987) · Cell and Tissue Research · doi:10.1007/bf00216495 · Cited by 83
Lectin-Mediated Drug Targeting: Preparation, Binding Characteristics, and Antiproliferative Activity of Wheat Germ Agglutinin Conjugated Doxorubicin on Caco-2 Cells
Wirth, M., Fuchs, A., Wolf, M., Ertl, B., & Gabor, F. (1998) · Pharmaceutical Research · doi:10.1023/a:1011926026653 · Cited by 82
Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8
Gabor, F., Stangl, M., & Wirth, M. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00043-1 · Cited by 78
Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches
Clark, M. A., Jepson, M. A., Simmons, N. L., & Hirst, B. H. (1994) · The Histochemical Journal · doi:10.1007/bf00166108 · Cited by 76
Self-citation
Up‐regulation of microsphere transport across the follicle‐associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a
Meynell, H. M., Thomas, N. W., James, P. S., Holland, J., Taussig, M., & Nicoletti, C. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.611 · Cited by 76
The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells
Rankin, S., Isberg, R. R., & Leong, J. M. (1992) · Infection and Immunity · doi:10.1128/iai.60.9.3909-3912.1992 · Cited by 76
Rapid appearance of M cells after microbial challenge is restricted at the periphery of the follicle-associated epithelium of Peyer's patch.
Borghesi, C., Taussig, M. J., & Nicoletti, C. (1999) · PubMed · Cited by 71
TWO MAMMALIAN CELL INTERNALIZATION STRATEGIES USED BY PATHOGENIC BACTERIA
Isberg, R. R., & Nhieu, G. T. V. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.002143 · Cited by 70
Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908
Barry, E. M., Gomez-Duarte, O. G., Chatfield, S. N., Rappuoli, R., Pizza, M., Losonsky, G. A., Galen, J. E., & Levine, M. M. (1996) · Infection and Immunity · doi:10.1128/iai.64.10.4172-4181.1996 · Cited by 68
Glycoconjugate Expression Defines the Origin and Differentiation Pathway of Intestinal M-cells
Gebert, A., & Posselt, W. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704501003 · Cited by 66
Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle‐associated M cells
Porta, C., James, P., Phillips, A. D., Savidge, T., Mw, S., & Cremaschi, D. (1992) · Experimental Physiology · doi:10.1113/expphysiol.1992.sp003662 · Cited by 65
Bioadhesion of Lectin-Latex Conjugates to Rat Intestinal Mucosa
Irache, J. M., Durrer, C., Duchêne, D., & Ponchel, G. (1996) · Pharmaceutical Research · doi:10.1023/a:1016405126656 · Cited by 65
Ultrastructural study of liposome uptake by M cells of rat Peyer's patch: an oral vaccine system for delivery of purified antigen.
Childers, N. K., Denys, F. R., McGee, N., & Michalek, S. M. (1990) · PubMed · Cited by 64
Targeting of drugs and vaccines to the gut
Wilding, I. R., Davis, S. S., & O’Hagan, D. T. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90006-x · Cited by 64
Targeting of mucosal vaccines to Peyer's patch M cells.
Frey, A. B., & Neutra, M. R. (1997) · PubMed · Cited by 63
Studies on the uptake of tomato lectin nanoparticles in everted gut sacs
Carreño-Gómez, B., Woodley, J. F., & Florence, A. J. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00050-2 · Cited by 62
The potential use of tomato lectin for oral drug delivery. 1. Lectin binding to rat small intestine in vitro
Naisbett, B., & Woodley, J. M. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90438-3 · Cited by 59
Development of Peyer's patches, follicle-associated epithelium and M cell: Lessons from immunodeficient and knockout mice
Debard, N., Sierro, F., & Kraehenbühl, J.-P. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0174 · Cited by 56
Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches
Clark, M. A., Jepson, M. A., Simmons, N. L., et al. (1994) · The Histochemical Journal · doi:10.1007/bf02388442 · Cited by 56
Self-citation
Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer’s Patches
Lelouard, H., Reggio, H., Mangeat, P. H., Neutra, M. R., & Montcourrier, P. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.357-367.1999 · Cited by 55
Lectin-mediated bioadhesion: Proteolytic stability and binding-characteristics of wheat germ agglutinin and Solanum tuberosum lectin on Caco-2, HT-29 and human colonocytes
Gabor, F., Wirth, M., Jurkovich, B., HABERL, I., Theyer, G., Walcher, G., & Hamilton, G. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00057-6 · Cited by 52
In vitro study of lectin-latex conjugates for specific bioadhesion
Irache, J. M., Durrer, C., Duchêne, D., & Ponchel, G. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)00033-6 · Cited by 50
Toward a poliovirus-based simian immunodeficiency virus vaccine: correlation between genetic stability and immunogenicity
Tang, S., van Rij, R. P., Silvera, D., & Andino, R. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7841-7850.1997 · Cited by 48
Localization of lectin binding sites in human, cat, and rabbit corneas.
Panjwani, N., Moulton, P., Alroy, J., & BAUM, J. L. (1986) · PubMed · Cited by 46
Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines
Brayden, D. J., & O’Mahony, D. J. (1998) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(98)00075-3 · Cited by 45
Plasticity of the gastrointestinal epithelium: The M cell paradigm and opportunism of pathogenic microorganisms
Kernéis, S. M., & Pringault, E. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0176 · Cited by 44
Identification of M-cells in the rabbit tonsil by vimentin immunohistochemistry and in vivo protein transport
Gebert, A. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01835154 · Cited by 43
Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin
Loregian, A., Papini, E., Satin, B., Marsden, H. S., Hirst, T. R., & Palù, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5221 · Cited by 42
Lectin-Mediated Drug Targeting: Quantification of Binding and Internalization of Wheat germ Agglutinin and Solatium tuberosum Lectin Using Caco-2 and HT-29 Cells
Wirth, M., Hamilton, G., & Gabora, F. (1998) · Journal of Drug Targeting · doi:10.3109/10611869808997885 · Cited by 41
The potential use of tomato lectin for oral drug delivery: 2. Mechanism of uptake in vitro
Naisbett, B., & Woodley, J. M. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90150-3 · Cited by 40
Receptor-mediated gene delivery employing lectin-binding specificity.
Batra, R. K., Wang‐Johanning, F., Wagner, E., Garver, R. I., & Curiel, D. (1994) · PubMed · Cited by 39
Variations in Lectin Binding Properties of Intestinal M Cells
Jepson, M. A., Mason, C. M., Clark, M. A., Simmons, N. L., & Hirst, B. H. (1995) · Journal of drug targeting · doi:10.3109/10611869509015938 · Cited by 38
Self-citation
M-cells in the rabbit tonsil exhibit distinctive glycoconjugates in their apical membranes.
Gebert, A. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.9.8773569 · Cited by 34
Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cellsin vitro
Rubas, W., Banerjea, A. C., Gallati, H., Speiser, P. P., & Joklik, W. K. (1990) · Journal of Microencapsulation · doi:10.3109/02652049009021848 · Cited by 34
The potential use of tomato lectin for oral drug delivery: 3. Bioadhesion in vivo
Naisbett, B., & Woodley, J. M. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)00242-w · Cited by 33
Lectins in ocular drug delivery: An investigation of lectin binding sites on the corneal and conjunctival surfaces
Nicholls, T. J. (1996) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(96)04540-1 · Cited by 33
Lectins for Drug Delivery within the Oral Cavity—Investigation of Lectin Binding to Oral Mucosa
Nantwi, P. K. K., Cook, D. J., Rogers, D. J., & Smart, J. D. (1997) · Journal of drug targeting · doi:10.3109/10611869708995857 · Cited by 33
Attenuated Salmonella typhi and Shigella as live oral vaccines and as live vectors.
Mm, L., Galen, J. E., Barry, E. M., Noriega, F. R., Tacket, C. O., Sztein, M. B., Chatfield, S. N., Gordon Dougan, B., Losonsky, G. A., & Kotloff, K. L. (1997) · PubMed · Cited by 33
Differential cytokeratin and glycoconjugate expression by the surface and crypt epithelia of human palatine tonsils
Clark, M. A., Wilson, C., Sama, A. M., Wilson, J. A., & Hirst, B. H. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180000198 · Cited by 29
Self-citation
Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit.
Marcello, A., Loregian, A., CROSS, A. M., Marsden, H. S., Hirst, T. R., & Palù, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8994 · Cited by 28
Lectin-mediated attachment of liposomes to cornea: influence on transcorneal drug flux.
Schaeffer, H. E., Breitfeller, J. M., & Krohn, D. L. (1982) · PubMed · Cited by 27
Binding of four lectins to normal human oral mucosa
Hietanen, J. H. P., & Salo, O. P. (1984) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1984.tb00914.x · Cited by 26
Lectin-Functionalized Multiple Emulsions for Improved Cancer Therapy
Khopade, A. J., Nandakumar, K. S., & Jainb, N. K. (1998) · Journal of drug targeting · doi:10.3109/10611869808996836 · Cited by 26
Vaccines against gut pathogens
Mastroeni, P., Bowe, F., Cahill, R., Simmons, C. P., & Gordon Dougan, B. (1999) · Gut · doi:10.1136/gut.45.5.633 · Cited by 22
Microparticulate delivery systems: potential drug/vaccine carriers via mucosal routes
Hillery, A. M. (1998) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(98)00024-8 · Cited by 19
The potential use of tomato lectin for oral drug delivery: 4. Immunological consequences
Naisbett, B. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)00398-o · Cited by 18
Lectin-binding sites in the epithelium of normal human appendix vermiformis and in acute appendicitis.
Brinck, U., Bosbach, R., Korabiowska, M., Schauer, A., & Gabius, H. (1995) · PubMed · Cited by 17
Oral Delivery of Microencapsulated Proteins
Dibiase, M., & Morrel, E. M. (2002) · Pharmaceutical biotechnology · doi:10.1007/0-306-46803-4_10 · Cited by 16
Bioadhesion to the intestine by means of E. coli K99-fimbriae:
Gabor, F., Bernkop‐Schnürch, A., & Hamilton, G. (1997) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(97)00279-0 · Cited by 14
Enterocytes in the follicle-associated epithelia of rabbit small intestine display distinctive lectin-binding properties
Jepson, M. A., Mason, C. M., Simmons, N. L., & Hirst, B. H. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01454010 · Cited by 13
Self-citation
Binding pattern of eight different lectins in healthy subjects and patients with dysplastic and malignant lesions of the oral cavity
Mazumdar, S., Sengupta, S. K., Param, R., & Sinha, S. N. (1993) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0901-5027(05)80521-1 · Cited by 12
Inhibition of lectin-binding to saliva-treated hydroxy apatite, to buccal epithelial cells, and to erythrocytes by salivary components
Gibbons, R., & Dankers, I. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.2.276 · Cited by 12
Glycoconjugate Expression in Follicle-Associated Epithelium(FAE) Covering the Nasal-Associated Lymphoid Tissue(NALT) in Specific Pathogen-Free and Conventional Rats.
Jeong, K. I., Uetsuka, K., Nakayama, H., & Doi, K. (1999) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.48.23 · Cited by 11
Detection of Blood Group Differences in Human Corneal Epithelium Using a Monoclonal Antibody and Lectins
Watanabe, H. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090170111032 · Cited by 11
Untitled work
(1996) · Europe PMC (PubMed Central)

Research works printed but not linked: 3

Caston, 1990, The potential of fimbrial proteins for delaying intestinal transit of oral drug delivery systems, Proc. Control. Release Soc., 17, 313
Wilson, 1998, Identification of cell subpopulations in human tonsillar epithelium [abstract], J. Anat., 192, D13
Russell-Jones, 1988, Vitamin B12: A novel carrier for orally presented antigens, Proc. Int. Symp. Control. Release Bioact. Mater., 15, 85

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Authors: Clark, M. A., Hirst, B. H., & Jepson, M. A.
Affiliations: Newcastle University (GB)
University of Bristol (GB)
Corresponding author: Jepson, Mark A
ORCID: Hirst, Barry H
Jepson, Mark A
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2000-09
Volume: 43
Issue: 2-3
Pages: 207-223
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(00)00070-3
OpenAlex: W2063013932
Cited by: 236
References: 121
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 17
FWCI: 1.41
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: lectins, mucosal drug delivery, M cells, intestinal mucosa, respiratory mucosa, oral mucosa, ocular drug delivery, microparticles, colloidal drug delivery, vaccine delivery, gastrointestinal tract
MeSH terms: Animals, Gastric Mucosa, Humans, Intestinal Absorption, Intestinal Mucosa, Nasal Mucosa, Vaccines, Drug Delivery Systems, Lectins

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Lectin-mediated mucosal delivery of drugs and microparticles

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