Cited by 236Advanced Drug Delivery SystemsGlycosylation and Glycoproteins ResearchInhalation and Respiratory Drug Delivery

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Lectin-mediated mucosal delivery of drugs and microparticles

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Clark, M.Ann, Hirst, Barry H, Jepson, Mark A·2000·Advanced Drug Delivery Reviews

DOI 10.1016/s0169-409x(00)00070-3

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Abstract

Absorption of drugs and vaccines at mucosal surfaces may be enhanced by conjugation to appropriate bioadhesins which bind to mucosal epithelia. Bioadhesins might also permit cell- and site-selective targeting. One approach is to exploit surface carbohydrates on mucosal epithelial cells for lectin-mediated delivery. We review work supporting the use of lectins as mucosal bioadhesins in the gastrointestinal and respiratory tracts, the oral cavity and the eye. The gastrointestinal tract is particularly favoured for mucosal delivery. Many studies have demonstrated that the antigen sampling intestinal M cells offer a portal for absorption of colloidal delivery vehicles. Evidence is presented that M cell targeting may be achieved using M cell-specific lectins, microbial adhesins or immunoglobulins. While many hurdles must be overcome before mucosal bioadhesins can guarantee consistent, safe, effective mucosal delivery, this is an exciting area of research that has important implications for future drug and vaccine formulation.

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Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle Size
Desai, M. P., Labhasetwar, V. D., Amidon, G. L., & Levy, R. J. (1996) · Pharmaceutical Research · doi:10.1023/a:1016085108889 · Cited by 942
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
Jani, P., Halbert, G. W., Langridge, J., & Florence, A. T. (1990) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1990.tb07033.x · Cited by 920
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.
Jones, B. D., Ghori, N., & Falkow, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.15 · Cited by 883
Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
Isberg, R. R., & Leong, J. M. (1990) · Cell · doi:10.1016/0092-8674(90)90099-z · Cited by 798
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
Eldridge, J. H., Hammond, C., Meulbroek, J. A., Staas, J. K., Gilley, R. M., & Tice, T. R. (1990) · Journal of Controlled Release · doi:10.1016/0168-3659(90)90133-e · Cited by 689
Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria
Kernéis, S. M., Bogdanova, A. A., Kraehenbühl, J.-P., & Pringault, E. (1997) · Science · doi:10.1126/science.277.5328.949 · Cited by 630
Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
Isberg, R. R., Voorhis, D. L., & Falkow, S. (1987) · Cell · doi:10.1016/0092-8674(87)90335-7 · Cited by 597
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
Florence, A. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012029517394 · Cited by 498
Intestinal M Cells: A Pathway for Entry of Reovirus into the Host
Wolf, J. L., Rubin, D. H., Finberg, R. W., Kauffman, R. S., Sharpe, A. H., Trier, J. S., & Fields, B. N. (1981) · Science · doi:10.1126/science.6259737 · Cited by 483
Immune responses to dietary antigens: oral tolerance
Ströbel, S., & Mowat, A. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01239-5 · Cited by 454

Show all 121 references

Research works printed but not linked: 3

Caston, 1990, The potential of fimbrial proteins for delaying intestinal transit of oral drug delivery systems, Proc. Control. Release Soc., 17, 313
Wilson, 1998, Identification of cell subpopulations in human tonsillar epithelium [abstract], J. Anat., 192, D13
Russell-Jones, 1988, Vitamin B12: A novel carrier for orally presented antigens, Proc. Int. Symp. Control. Release Bioact. Mater., 15, 85

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Authors: Clark, M. A., Hirst, B. H., & Jepson, M. A.
Affiliations: Newcastle University (GB)
University of Bristol (GB)
Corresponding author: Jepson, Mark A
ORCID: Hirst, Barry H
Jepson, Mark A
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2000-09
Volume: 43
Issue: 2-3
Pages: 207-223
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/s0169-409x(00)00070-3
OpenAlex: W2063013932
Cited by: 236
References: 121
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 8 · 2017: 10 · 2016: 7 · 2015: 14 · 2014: 6 · 2013: 14 · 2012: 17
FWCI: 1.41
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: lectins, mucosal drug delivery, M cells, intestinal mucosa, respiratory mucosa, oral mucosa, ocular drug delivery, microparticles, colloidal drug delivery, vaccine delivery, gastrointestinal tract
MeSH terms: Animals, Gastric Mucosa, Humans, Intestinal Absorption, Intestinal Mucosa, Nasal Mucosa, Vaccines, Drug Delivery Systems, Lectins

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Lectin-mediated mucosal delivery of drugs and microparticles

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