The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
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“Other simulations of evolving ecosystems confirm the generative potential of artificial life systems [300,314–317].”
From Fundamental constraints to the logic of living systems (2024) · cites this paper as [316]
Citations
Cites
The Hypercycle: A principle of natural self-organization
Eigen, M., & Schuster, P. M. (1979) · Cited by 1,906
Cooperation and Competition in the Evolution of ATP-Producing Pathways
Pfeiffer, T., Schuster, S., & Bonhoeffer, S. (2001) · Science · doi:10.1126/science.1058079 · Cited by 1,365
Deleterious mutations and the evolution of sexual reproduction
Kondrashov, A. S. (1988) · Nature · doi:10.1038/336435a0 · Cited by 1,127
Lenski, R. E., & Travisano, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.6808 · Cited by 1,020
Automatic design and manufacture of robotic lifeforms
Lipson, H., & Pollack, J. B. (2000) · Nature · doi:10.1038/35023115 · Cited by 896
The fate of competing beneficial mutations in an asexual population
Gerrish, P. J., & Lenski, R. E. (1998) · Genetica · doi:10.1023/a:1017067816551 · Cited by 895
Evolution of high mutation rates in experimental populations of E. coli
Sniegowski, P. D., Gerrish, P. J., & Lenski, R. E. (1997) · Nature · doi:10.1038/42701 · Cited by 879
The fate of competing beneficial mutations in an asexual population
Gerrish, P. J., & Lenski, R. E. (1998) · Contemporary issues in genetics and evolution · doi:10.1007/978-94-011-5210-5_12 · Cited by 747
Langton, C. G., Taylor, C., Farmer, D., & Rasmussen, S. (1991) · Cited by 706
Evolution of digital organisms at high mutation rates leads to survival of the flattest
Wilke, C. O., Wang, J. L., Ofria, C., Lenski, R. E., & Adami, C. (2001) · Nature · doi:10.1038/35085569 · Cited by 623
Self-citationEvolution of biological complexity
Adami, C., Ofria, C., & Collier, T. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4463 · Cited by 592
Self-citationA pluralist approach to sex and recombination
West, S. A., Lively, & Read (1999) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.1999.00119.x · Cited by 544
The population genetics of ecological specialization in evolving Escherichia coli populations
Cooper, V. S., & Lenski, R. E. (2000) · Nature · doi:10.1038/35037572 · Cited by 519
Experimental Tests of the Roles of Adaptation, Chance, and History in Evolution
Travisano, M., Mongold, J. A., Bennett, A. F., & Lenski, R. E. (1995) · Science · doi:10.1126/science.7809610 · Cited by 503
A general model for the evolution of recombination
Barton, N. (1995) · Genetics Research · doi:10.1017/s0016672300033140 · Cited by 424
Test of synergistic interactions among deleterious mutations in bacteria
Elena, S. F., & Lenski, R. E. (1997) · Nature · doi:10.1038/37108 · Cited by 416
Introduction To Artificial Life
Adami, C. (1998) · IEEE Transactions on Evolutionary Computation · doi:10.1109/tevc.1998.738989 · Cited by 404
Self-citationSelection against harmful mutations in large sexual and asexual populations
Kondrashov, A. S. (1982) · Genetics Research · doi:10.1017/s0016672300019194 · Cited by 327
Genome complexity, robustness and genetic interactions in digital organisms
Lenski, R. E., Ofria, C., Collier, T. C., & Adami, C. (1999) · Nature · doi:10.1038/23245 · Cited by 306
Self-citationEvolvability of an RNA virus is determined by its mutational neighbourhood
Burch, C. L., & Chao, L. (2000) · Nature · doi:10.1038/35020564 · Cited by 257
Fitness effects of advantageous mutations in evolving Escherichia coli populations
Imhof, M., & Schlötterer, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1113 · Cited by 249
Stationary mutant distributions and evolutionary optimization
Schuster, P., & Swetina, J. (1988) · Bulletin of Mathematical Biology · doi:10.1016/s0092-8240(88)80059-4 · Cited by 203
Efficiency of truncation selection
Crow, J. F., & Kimura, M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.396 · Cited by 201
Rice, S. H. (1998) · Evolution · doi:10.1111/j.1558-5646.1998.tb03690.x · Cited by 200
SELECTIVE MECHANISMS IN BACTERIAPreprint
Atwood, K. C., Schneider, L. K., & Rryan, F. J. (1951) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1951.016.01.026 · Cited by 196
Muller's ratchet under epistatic selection.
Kondrashov, A. S. (1994) · Genetics · doi:10.1093/genetics/136.4.1469 · Cited by 170
Quasispecies Theory in Virology
Domingo, E. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.463-465.2002 · Cited by 152
Whitlock, M. C., & Bourguet, D. (2000) · Evolution · doi:10.1111/j.0014-3820.2000.tb00709.x · Cited by 141
Bedau, M. A., McCaskill, J. S., & Rasmussen, S. (2000) · The MIT Press eBooks · doi:10.7551/mitpress/1432.001.0001 · Cited by 130
Is the Quasispecies Concept Relevant to RNA Viruses?
Holmes, E. C., & Moyá, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.460-462.2002 · Cited by 128
The coreworld: Emergence and evolution of cooperative structures in a computational chemistry
Rasmussen, S., Knudsen, C., Feldberg, R., & Hindsholm, M. (1990) · Physica D Nonlinear Phenomena · doi:10.1016/0167-2789(90)90070-6 · Cited by 116
Self-organized criticality in living systems
Adami, C. (1995) · Physics Letters A · doi:10.1016/0375-9601(95)00372-a · Cited by 107
Self-citationInteraction between directional epistasis and average mutational effects
Wilke, C. O., & Adami, C. (2001) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2001.1690 · Cited by 107
Self-citationFoster, J. A. (2001) · Nature Reviews Genetics · doi:10.1038/35076523 · Cited by 105
Evolution, complexity, entropy and artificial reality
Ray, T. S. (1994) · Physica D: Nonlinear Phenomena · doi:10.1016/0167-2789(94)90286-0 · Cited by 93
An Experimental Test for Synergistic Epistasis and Its Application in Chlamydomonas
de Visser, J. A. G. M., Hoekstra, R. F., & ENDE, H. V. D. (1997) · Genetics · doi:10.1093/genetics/145.3.815 · Cited by 86
Genetic measurement theory of epistatic effects
Wagner, G. P., Laubichler, M. D., & Bagheri, H. C. (1998) · Contemporary issues in genetics and evolution · doi:10.1007/978-94-011-5210-5_43 · Cited by 75
McRobb, L. S., & Ferenci, T. (2000) · Genetics · doi:10.1093/genetics/156.4.1493 · Cited by 67
Little Evidence for Synergism Among Deleterious Mutations in a Nonsegmented RNA Virus
Elena, S. F. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00000082 · Cited by 63
EFFECT OF DELETERIOUS MUTATION-ACCUMULATION ON THE FITNESS OF RNA BACTERIOPHAGE MS2
de la Peña, M., Elena, S. F., & Moyá, A. (2000) · Evolution · doi:10.1554/0014-3820(2000)054[0686:eodmao]2.0.co;2 · Cited by 58
Smith, J. M. (1992) · Nature · doi:10.1038/355772a0 · Cited by 57
Testing for Epistasis Between Deleterious Mutations
West, S. A., Peters, A. D., & Barton, N. (1998) · Genetics · doi:10.1093/genetics/149.1.435 · Cited by 57
Genetic measurement theory of epistatic effects
Wagner, G. P., Laubichler, M. D., & Bagheri, H. C. (1998) · Genetica · doi:10.1023/a:1017088321094 · Cited by 57
A Test for Epistasis Among Induced Mutations in Caenorhabditis elegans
Peters, A. D., & Keightley, P. D. (2000) · Genetics · doi:10.1093/genetics/156.4.1635 · Cited by 53
Microevolution in an Electronic Microcosm
Yedid, G., & Bell, G. (2001) · The American Naturalist · doi:10.1086/319928 · Cited by 52
The spontaneous generation of digital “Life”
Pargellis, A. N. (1996) · Physica D Nonlinear Phenomena · doi:10.1016/0167-2789(95)00268-5 · Cited by 43
Wloch, D. M., Borts, R. H., & Korona, R. (2001) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2001.00267.x · Cited by 38
Synergistic epistasis between loci affecting fitness: evidence in plants and fungi
de Visser, J. A. G. M., & Hoekstra, R. F. (1998) · Genetics Research · doi:10.1017/s0016672397003091 · Cited by 35
Soluble Model for the Accumulation of Mutations in Asexual Populations
Colato, A., & Fontanari, J. F. (2001) · Physical Review Letters · doi:10.1103/physrevlett.87.238102 · Cited by 26
Maternal Effects in Molecular Evolution
Wilke, C. O. (2002) · Physical Review Letters · doi:10.1103/physrevlett.88.078101 · Cited by 17
Self-citationEvolution of Differentiated Expression Patterns in Digital Organisms
Ofria, C., Adami, C., Collier, T. C., & Hsu, G. K. (1999) · Lecture notes in computer science · doi:10.1007/3-540-48304-7_19 · Cited by 15
Self-citationAB INITIO MODELING OF ECOSYSTEMS WITH ARTIFICIAL LIFE
Adami, C. (2002) · Natural Resource Modeling · doi:10.1111/j.1939-7445.2002.tb00083.x · Cited by 14
Self-citationIntroduction to Artificial Life
Gelepithis, P. A. M. (1999) · AI & Society · doi:10.1007/bf01205990 · Cited by 7
Influence of Chance, History and Adaptation on Evolution in Digitalia
Wagenaar, D. A., & Adami, C. (2000) · The MIT Press eBooks · doi:10.7551/mitpress/1432.003.0029 · Cited by 7
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Self-citationRobustness can evolve gradually in complex regulatory gene networks with varying topology
Ciliberti, S., Martin, O. C., & Wagner, A. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030015 · Cited by 390
Adami, C. (2002) · BioEssays · doi:10.1002/bies.10192 · Cited by 397
Self-citationThe population genetics and evolutionary epidemiology of RNA viruses
Moyá, A., Holmes, E. C., & Gónzález‐Candelas, F. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro863 · Cited by 402
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Ofria, C., & Wilke, C. O. (2004) · Artificial Life · doi:10.1162/106454604773563612 · Cited by 378
Self-citation
Metadata
- Authors
- Wilke, C. O., & Adami, C.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Wilke, Claus O.
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 17
- Issue
- 11
- Pages
- 528-532
- ISSN
- 0169-5347 (ISSN-L)
- OpenAlex
- W2159830634
- Cited by
- 103
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 1 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Ecology & Evolution (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Computer Science › Artificial Intelligence › Evolutionary Algorithms and Applications
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- digital organisms, artificial life, self-replicating programs, computer viruses, selective breeding, adaptive evolution, complexity growth, epistasis
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