Wilke, Claus O.

Welcome to the tidyverse

Wickham, H., Averick, M., Bryan, J., Chang, W., McGowan, L., François, R., Grolemund, G., Hayes, A., Henry, L., Hester, J., et al. (2019) · Journal of Open Source Software

Data Analysis with RScientific Computing and Data Management

Cited by 22,138

Why highly expressed proteins evolve slowly

Drummond, D. A., Bloom, J. D., Adami, C., Wilke, C. O., & Arnold, F. H. (2005) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 815

The evolutionary consequences of erroneous protein synthesis

Allan Drummond, D., & Wilke, C. O. (2009) · Nature Reviews Genetics

RNA and protein synthesis mechanismsEvolution and Genetic Dynamics

Cited by 515

A universal trend of reduced mrna stability near the translation-initiation site in prokaryotes and eukaryotes

Gu, W., Zhou, T., & Wilke, C. O. (2010) · PLoS Computational Biology

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 313

Theory of lethal mutagenesis for viruses

Bull, J. J., Sanjuán, R., & Wilke, C. O. (2007) · Journal of Virology

Evolution and Genetic DynamicsMathematical and Theoretical Epidemiology and Ecology Models

Cited by 281

Quasispecies theory in the context of population genetics

Wilke, C. O. (2005) · BMC Evolutionary Biology

Evolution and Genetic DynamicsMathematical and Theoretical Epidemiology and Ecology Models

Cited by 276

The biology of digital organisms

Wilke, C. O., & Adami, C. (2002) · Trends in Ecology & Evolution

Evolution and Genetic DynamicsEvolutionary Algorithms and Applications

Cited by 103

The look-ahead effect of phenotypic mutations

Whitehead, D. J., Wilke, C. O., Vernazobres, D., & Bornberg-Bauer, E. (2008) · Biology Direct

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 84

SELECTION FOR FITNESS VERSUS SELECTION FOR ROBUSTNESS IN RNA SECONDARY STRUCTURE FOLDING

Wilke, C. O. (2001) · Evolution

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 76

EFFECTS OF POPULATION SIZE AND MUTATION RATE ON THE EVOLUTION OF MUTATIONAL ROBUSTNESS

Elena, S. F., Wilke, C. O., Ofria, C., & Lenski, R. E. (2007) · Evolution

Evolution and Genetic DynamicsEvolutionary Algorithms and Applications

Cited by 73

Lethal mutagenesis of bacteria.

Bull, J. J., & Wilke, C. O. (2008) · Genetics

Evolution and Genetic DynamicsBacteriophages and microbial interactions

Cited by 48

Medium-sized protein language models perform well at transfer learning on realistic datasets

Vieira, L. C., Handojo, M. L., & Wilke, C. O. (2025) · Scientific Reports

Machine Learning in BioinformaticsProtein Structure and Dynamics

Cited by 41

Learning the local landscape of protein structures with convolutional neural networks

Kulikova, A. V., Diaz, D. J., Loy, J. M., Ellington, A. D., & Wilke, C. O. (2021) · Journal of Biological Physics

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 23

Two sequence- and two structure-based ML models have learned different aspects of protein biochemistry

Kulikova, A. V., Diaz, D. J., Chen, T., Cole, T. J., Ellington, A. D., & Wilke, C. O. (2023) · Scientific Reports

Machine Learning in BioinformaticsProtein Structure and Dynamics

Cited by 15

A systematic evaluation of the language-of-viral-escape model using multiple machine learning frameworks

Allman, B. E., Vieira, L., Diaz, D. J., & Wilke, C. O. (2025) · Journal of The Royal Society Interface

SARS-CoV-2 and COVID-19 ResearchEvolution and Genetic Dynamics

Cited by 11

Semantic search using protein large language models detects class II microcins in bacterial genomes

Kulikova, A. V., Parker, J. K., Davies, B. W., & Wilke, C. O. (2024) · mSystems

Antimicrobial Peptides and ActivitiesMicrobial Natural Products and Biosynthesis

Cited by 10