Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion

Johansson, Anna G.; Baylink, David J.; af Ekenstam, Eva; Lindh, Erik; Mohan, Subburaman; Ljunghall, Sverker

doi:10.1016/s0169-6009(08)80128-6

Cited by 45Growth Hormone and Insulin-like Growth FactorsParathyroid Disorders and TreatmentsBone Metabolism and Diseases

Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion

Johansson, Anna G., Baylink, David J., af Ekenstam, Eva, Lindh, Erik, Mohan, Subburaman, Ljunghall, Sverker·1994·Bone and Mineral

DOI 10.1016/s0169-6009(08)80128-6

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Abstract

In order to assess if the anabolic action of PTH is related to changes in circulating levels of insulin-like growth factor-I and -II (IGF-I and -II), and IGF binding protein 3 (IGFBP-3), 24 h of PTH infusion was performed in healthy women and in patients with rheumatoid arthritis (RA), a state where both bone metabolism and PTH secretion is influenced by the inflammatory activity. The patients with RA had lower basal levels of both IGF-I and -II than the healthy controls (P < 0.05). In neither group did the IGFs change after 24 h of PTH administration, while IGFBP-3 was significantly increased in the healthy controls (4600 +/- 1200 to 5750 +/- 2200 micrograms/l, P < 0.05). IGFBP-3 was not affected by PTH infusion in patients with RA when the disease had high activity, but when inflammation had subsided they responded with a similar increase in IGFBP-3 as the control group and basal IGF-I and -II levels were normalised. Since IGFBP-3 can enhance the anabolic action of IGF-I, increased IGFBP-3 levels after PTH infusion may reflect a mechanism by which PTH is anabolic for bone. Inflammation may inhibit bone formation via decreased serum levels of IGFs and blocked IGFBP-3 response to PTH.

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IGF-1 levels are typically decreased in chronic inflammation.
“IGF-1 levels are typically decreased in chronic inflammation [88-90].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [89]

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Authors: Johansson, A. G., Baylink, D. J., af Ekenstam, E., Lindh, E., Mohan, S., & Ljunghall, S.
Affiliations: Uppsala University Hospital (SE)
Jerry L. Pettis Memorial VA Medical Center (US)
Loma Linda University (US)
Corresponding author: Johansson, Anna G.
ORCID: Baylink, David J.
Mohan, Subburaman
Venue: Bone and Mineral
Publisher: Elsevier BV
Published: 1994-01
Volume: 24
Issue: 1
Pages: 25-31
ISSN: 0169-6009 (ISSN-L)
DOI: 10.1016/s0169-6009(08)80128-6
OpenAlex: W1967077548
Cited by: 45
References: 28
Citations by year: 2020: 1 · 2019: 2 · 2018: 1 · 2015: 5 · 2014: 1 · 2013: 1
FWCI: 1.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Bone and Mineral (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Medicinska Forskningsrådet
National Institutes of Health (AR31062)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: insulin-like growth factor I, insulin-like growth factor II, IGF binding protein-3, parathyroid hormone, rheumatoid arthritis, inflammation, bone metabolism, bone formation
MeSH terms: Adult, Aged, Arthritis, Rheumatoid, Bone and Bones, Calcium, Carrier Proteins, Female, Humans, Infusion Pumps, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male, Middle Aged, Parathyroid Hormone, Peptide Fragments, Insulin-Like Growth Factor Binding Proteins

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Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion

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