Cited by 87Orthopaedic implants and arthroplastyBone Metabolism and DiseasesOsteoarthritis Treatment and Mechanisms

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The expression of osteoclast markers on foreign body giant cells

Kadoya, Y., Al-Saffar, N., Kobayashi, A., Revell, P.A.·1994·Bone and Mineral

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Abstract

The expression of some candidate osteoclast markers, tartrate-resistant acid phosphatase (TRAP), macrophage associated antigens (M phi Ag), and vitronectin receptor (VNR) on foreign body giant cells (FBGCs) was investigated in peri-implant tissues of loosened total joint arthroplasties. Osteoclasts showed distinct staining characteristics. They were strongly TRAP-positive at tartrate concentrations of 50-200 mM and expressed VNR and a restricted range of M phi Ag. In contrast, FBGCs were shown to be significantly heterogeneous. Significant numbers of FBGCs were TRAP-positive at a 100 mM tartrate concentration and some were more intense than osteoclasts. A population of FBGCs did not express M phi Ag such as CD11b, but expressed VNR. It was demonstrated that these candidate osteoclast markers were also positive on FBGCs. These results have highlighted the difficulty in distinguishing these two cell lineages and suggested that there might be some uncertainty in defining osteoclast-like cells in culture studies.

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Authors: Kadoya, Y., Al-Saffar, N., Kobayashi, A., & Revell, P. A.
Affiliations: The Royal Free Hospital (GB)
Corresponding author: Kadoya, Y.
ORCID: Kobayashi, A.
Venue: Bone and Mineral
Publisher: Elsevier BV
Published: 1994
Volume: 27
Issue: 2
Pages: 85-96
ISSN: 0169-6009 (ISSN-L)
DOI: 10.1016/s0169-6009(08)80211-5
OpenAlex: W2072466744
Cited by: 87
References: 25
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 4
FWCI: 5.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Bone and Mineral (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: osteoclast markers, foreign body giant cells, tartrate-resistant acid phosphatase, integrin αvβ3, peri-implant tissues, osteoclast-like cells, CD11b, lineage differentiation
MeSH terms: Acid Phosphatase, Antigen-Antibody Reactions, Antigens, Differentiation, Arthroplasty, Bone Resorption, Calcinosis, Cells, Cultured, Femur, Foreign Bodies, Histocytochemistry, Humans, Immunohistochemistry, Macrophages, Membrane Glycoproteins, Osteoclasts, Tibia, Biomarkers, Giant Cells, Granuloma, Foreign-Body, Integrins, Receptors, Cytoadhesin, Receptors, Vitronectin, Prostheses and Implants, Galectin 3

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The expression of osteoclast markers on foreign body giant cells

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