The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice
Abstract
Multiple lines of evidence indicate that inflammatory processes are involved in the pathogenesis of Alzheimer's disease. Lipopolysaccharide (LPS) is widely used to induce inflammation in experimental systems. Consequently we injected LPS or saline intrahippocampally in 11 and 16 months old APP+PS1 transgenic mice to induce brain inflammation, then used immunocytochemistry to examine amyloid pathology 7 days later. As expected, LPS activated microglia as indicated by a significant increase in the area covered by major histocompatibility complex-II (MHC-II) immunostaining in the mice injected with LPS compared to the saline injected. Simultaneously, Abeta immunostaining showed an unexpected reduction of the Abeta load in the mice injected with LPS compared to the saline injected. This effect of LPS on the Abeta load in APP+PS1 mice strengthens the hypothesis that moderate amounts of microglial activation may be beneficial in Alzheimer's disease, by increasing the clearance of Abeta.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, increased gliosis induced by brain infusion of lipopolysaccharide (4) or overexpression of the inflammatory cytokine interleukin-6 (5) or interferon-γ (6) markedly reduces amyloid plaque burden.”
From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [4]
Citations
Cites
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386
Theory and Practice of Histotechnology
Sheehan, D. C., & Hrapchak, B. B. (1973) · Medical Entomology and Zoology · Cited by 1,128
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817
Selected histochemical and histopathological methods
Thompson, S. W., & Hunt, R. D. (1966) · C.C. Thomas eBooks · Cited by 521
Immune System Response in Alzheimer's Disease
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029863 · Cited by 463
Cited by
Sorted by citations
Items 201–223 of 223
Alzheimer's Disease BACE Proteases
Roßner, S., & Lichtenthaler, S. F. (2008) · Springer eBooks · doi:10.1007/978-0-387-32671-9_11 · Cited by 1
The tango of immune and neural cells: orchestrating neuroinflammation mediated brain disorders
Wu, Y., Lyu, W., Xie, X., Fu, X., Zhang, L., & Pan, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1827437 · Cited by 1
Church, K. A., Cardona, A. E., & Hopp, S. C. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_15 · Cited by 1
Inflammation and insulin resistance in Alzheimer’s disease
Nash, Y., & Frenkel, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00025-6 · Cited by 1
The Involvement of Aβ in the Neuroinflammatory Response
Eikelenboom, P., van Gool, W. A., Rozemüller, A. J. M., Scheper, W., Veerhuis, R., & Hoozemans, J. J. M. (2006) · Springer eBooks · doi:10.1007/978-1-84628-440-3_4 · Cited by 1
Heparan Sulfate in the Amyloidosis and Inflammation of Alzheimer’s Disease
O′Callaghan, P. W. (2011) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Genetic and Toxicological Models of Neurodegenerative Diseases
Campbell, A., & Bondy, S. B. C. (2004) · Informa Healthcare eBooks · doi:10.1201/9780203503317.ch6 · Cited by 1
Herber, D. L. (2004) · Digital Commons - University of South Florida (University of South Florida)
Campbell, A., & Bondy, S. C. (2004) · CRC Press eBooks · doi:10.1201/9780203503317-10
Shippy, D. C. (2005) · Digital Commons - University of South Florida (University of South Florida)
Pennington, A. R. (2012) · Digital Commons - University of South Florida (University of South Florida)
Monocytes as Gene Therapy Vectors for the Treatment of Alzheimer’s Disease
Lebson, L. A. (2008) · Digital Commons - University of South Florida (University of South Florida)
Murtishaw, A. S. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/6456429
Microglia in the Alzheimers brain: a help or a hindrance?
Vollert, C. T., & Eriksen, J. L. (2014) · AIMS neuroscience · doi:10.3934/neuroscience.2014.3.210
World population. Past, present and future trends.
Tarcă, M. (1990) · PubMed
cAMP-specific Pde4B mediates A_-induced microglial activation
Boulé, M., Lagacé, C., Ouellette, M., Gervais, F., Lacombe, D., McLaughlin, R., Sebastiani, G., Morissette, C., & Tremblay, P. J. (2004) · CRC Press eBooks · doi:10.1201/9781420037494.ch131
Role of Microglia and Astrocytesin Alzheimer’s Disease
Schubert, P., & Ferroni, S. (2004) · CRC Press eBooks · doi:10.1201/9781420039740.ch18
Neuroinflammation in Alzheimer's Disease and Vascular Cognitive Impairment
Weekman, E. M. (2017) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2017.051
(2007) · Steinkopff eBooks · doi:10.1007/978-3-7985-1787-5_7
Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injuryPreprint
Cheng, W. H., Cheung, H., Kang, A., Fan, J., Cooper, J. G., Anwer, M., Barrón, C., Wilkinson, A., Hu, G., Yue, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.01.506145
Talsma, A. D., Niemi, J. P., & Zigmond, R. E. (2024) · Figshare · doi:10.6084/m9.figshare.26726198
Dong, L., Doorduin, J., & de Vries, E. F. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106771
Metadata
- Authors
- DiCarlo, G.
- Affiliations
- University of South Florida (US)
- Corresponding author
- DiCarlo, G
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 22
- Issue
- 6
- Pages
- 1007-1012
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1993909442
- Cited by
- 223
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 12 · 2015: 15 · 2014: 11 · 2013: 8 · 2012: 21
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG018478, AG 15490, R01AG015490, AG18478)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- lipopolysaccharide, Alzheimer's disease, amyloid-beta, APP/PS1 mice, microglial activation, neuroinflammation, hippocampus, MHC class II, amyloid-beta clearance, intrahippocampal injection
- MeSH terms
- Animals, Gene Expression Regulation, Genes, MHC Class II, Hippocampus, Immunohistochemistry, Lipopolysaccharides, Membrane Proteins, Mice, Transgenic, Microinjections, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Microglia, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
