Cited by 223Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

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Intrahippocampal LPS injections reduce AÎ² load in APP+PS1 transgenic mice

DiCarlo, G·2001·Neurobiology of Aging

DOI 10.1016/s0197-4580(01)00292-5

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Abstract

Multiple lines of evidence indicate that inflammatory processes are involved in the pathogenesis of Alzheimer's disease. Lipopolysaccharide (LPS) is widely used to induce inflammation in experimental systems. Consequently we injected LPS or saline intrahippocampally in 11 and 16 months old APP+PS1 transgenic mice to induce brain inflammation, then used immunocytochemistry to examine amyloid pathology 7 days later. As expected, LPS activated microglia as indicated by a significant increase in the area covered by major histocompatibility complex-II (MHC-II) immunostaining in the mice injected with LPS compared to the saline injected. Simultaneously, Abeta immunostaining showed an unexpected reduction of the Abeta load in the mice injected with LPS compared to the saline injected. This effect of LPS on the Abeta load in APP+PS1 mice strengthens the hypothesis that moderate amounts of microglial activation may be beneficial in Alzheimer's disease, by increasing the clearance of Abeta.

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Authors: DiCarlo, G.
Affiliations: University of South Florida (US)
Corresponding author: DiCarlo, G
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2001-12
Volume: 22
Issue: 6
Pages: 1007-1012
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(01)00292-5
OpenAlex: W1993909442
Cited by: 223
References: 28
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 12 · 2015: 15 · 2014: 11 · 2013: 8 · 2012: 21
FWCI: 4.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG018478, AG 15490, R01AG015490, AG18478)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: lipopolysaccharide, Alzheimer's disease, amyloid-beta, APP/PS1 mice, microglial activation, neuroinflammation, hippocampus, MHC class II, amyloid-beta clearance, intrahippocampal injection
MeSH terms: Animals, Gene Expression Regulation, Genes, MHC Class II, Hippocampus, Immunohistochemistry, Lipopolysaccharides, Membrane Proteins, Mice, Transgenic, Microinjections, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Microglia, Mice, Presenilin-1

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Intrahippocampal LPS injections reduce AÎ² load in APP+PS1 transgenic mice

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