Anomalies cérébrales subtiles de l’Adrénomyéloneuropathie
Abstract
Purpose To describe subtle brain abnormalities detected on MRI in adult patients with adrenomyeloneuropathy (AMN). Materials and methods. Retrospective evaluation of data acquired prospectively as part of a clinical trial (Riluzole) in 66 adult patients with AMN without obvious brain lesion on MR. All patients underwent brain MR including T1W, T2W, FLAIR and spectroscopy. After a review had been validated by three different reviewers, review of MR images was performed by consensus using a semi-quantitative scale.Results Preliminary analysis of MR images confirmed the presence of signal abnormalities involving the corticospinal tracts in 36 patients (54.6%). Additional subtle abnormalities were also detected: white matter palor, mainly parieto-occipital in location, with patchy hyperintensity in 36 patients (54.6%), hyperintense pontocerebellar fibers on T2W and FLAIR in 25 patients (41.7%). The presence of elevated Cho/Cr and mI/Cr ratios, described in the literature, were confirmed.Conclusion This retrospective study allows the description of an AMN pattern on MRI in patients without white matter or callosal abnormalities.
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- Authors
- Teriitehau, C., Adamsbaum, C., Merzoug, V., Kalifa, G., Tourbah, A., & Aubourg, P.
- Affiliations
- Hôpital d'instruction des Armées Percy (FR)
- Hôpital Saint-Vincent-de-Paul (FR)
- Pitié-Salpêtrière Hospital (FR)
- Corresponding author
- Teriitehau, C.
- Venue
- Journal de Radiologie
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 88
- Issue
- 7-8
- Pages
- 957-961
- ISSN
- 0221-0363 (ISSN-L)
- OpenAlex
- W1979693503
- Cited by
- 10
- References
- 15
- Citations by year
- 2026: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2014: 2 · 2012: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Journal de Radiologie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- brain MRI abnormalities, Cho/Cr ratio, myelin water fraction, riluzole, adult patients, neuroimaging biomarkers, cerebrospinal fluid flow
- MeSH terms
- Adolescent, Adrenoleukodystrophy, Adult, Aspartic Acid, Brain, Cerebellopontine Angle, Choline, Creatine, Female, Humans, Image Processing, Computer-Assisted, Inositol, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Magnetic Resonance Spectroscopy, Parietal Lobe, Prospective Studies, Pyramidal Tracts, Retrospective Studies, Temporal Lobe, Internal Capsule, Diffusion Magnetic Resonance Imaging
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