Antioxidant transport by the human placenta

Schenker, S.; Yang, Y.; Perez, A.; Acuff, R.V.; Papas, A.M.; Henderson, G.; Lee, M.P.

doi:10.1016/s0261-5614(98)80052-6

Cited by 68Pregnancy and preeclampsia studiesAntioxidant Activity and Oxidative StressPregnancy and Medication Impact

Antioxidant transport by the human placenta

Schenker, S., Yang, Y., Perez, A., Acuff, R.V., Papas, A.M., Henderson, G., Lee, M.P.·1998·Clinical Nutrition

DOI 10.1016/s0261-5614(98)80052-6

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Abstract

We investigated the transfer of three antioxidants - melatonin, S-adenosyl methionine (SAM) and various forms of vitamin E - across the term, normal human placenta. The transport technique involved the single, isolated placental cotyledon system in vitro. Melatonin crossed the placental rapidly, equally to the freely diffusible marker, antipyrine. There was no biotransformation of the agent. SAM was transferred slowly, similarly to passively transported L-glucose as a marker. There was a breakdown of SAM to at least one other derivative; the process appeared to be nonenzymatic. Vitamin E was transferred slowly, at a rate only 10% of L-glucose. The natural RRR (nonracemic) form of vitamin E was transported best. Free vitamin, rather than the acetate seems to be transferred best, a finding that will require further study.

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Melatonin from the mother readily passes through the placenta and the fetal blood-brain barrier and may thus be the predominant relay of time-of-day information to the fetus, particularly during the transition from dusk to night as circulating melatonin rises.
“Melatonin from the mother readily passes through the placenta and the fetal blood–brain barrier and may thus be the predominant relay of time-of-day information to the fetus, particularly during the transition from dusk to night, as circulating melatonin rises31–34.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [32]

RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY
Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780 · see citing works
Physicians Desk Reference
Arky, R. A. (1994) · Cited by 2,632 · see citing works
SALMONELLAS IN MEAT.
Wickstrom, L., & Pettersson, K. (1964) · PubMed · Cited by 1,155 · see citing works
Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability
Burton, G. W., & Traber, M. G. (1990) · Annual Review of Nutrition · doi:10.1146/annurev.nu.10.070190.002041 · Cited by 760 · see citing works
Direct radioimmunoassay for melatonin in plasma.
Fraser, S., Cowen, P. J., Franklin, M., Franey, C. S., & Arendt, J. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.2.396 · Cited by 578 · see citing works
Transfer across the perfused human placenta of antipyrine, sodium, and leucine
Schneider, H., Panigel, M., & Dancis, J. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90909-x · Cited by 472 · see citing works
Vitamin E as an in Vitro and in Vivo Antioxidanta
Burton, G. W., & Ingold, K. U. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb14904.x · Cited by 449 · see citing works
Vitamin E in health and disease
Fuchs, J., & Packer, L. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90134-g · Cited by 378 · see citing works
Melatonin—A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroa
Pöeggeler, B., Saarela, S. Y. O., Reiter, R. J., Tan, D. X., CHEN, L., Manchester, L. C., & Barlow‐Walden, L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21831.x · Cited by 351 · see citing works
Advances in Pineal Research
Ur, E. (1991) · Postgraduate Medical Journal · doi:10.1136/pgmj.67.787.497 · Cited by 345 · see citing works
The Fate of Melatonin in Animals
Kopin, I. J., Pare, C. M. B., Axelrod, J., & Weissbach, H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76431-x · Cited by 338 · see citing works
A high-performance liquid chromatographic method for the determination of tocopherol in plasma and cellular elements of the blood.
Hatam, L. J., & Kayden, H. J. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40587-5 · Cited by 334 · see citing works
Nuclear localization of melatonin in different mammalian tissues: Immunocytochemical and radioimmunoassay evidence
Menéndez-Peláez, A., Pöeggeler, B., Reiter, R. J., Barlow‐Walden, L., Pablos, M. I., & Tan, D.-X. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240530415 · Cited by 325 · see citing works
Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats
Melchiorri, D., Reiter, R. J., Attia, A. M., Hara, M., Burgos, A., & Nistico, G. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00928-7 · Cited by 275 · see citing works
Melatonin in Relation to Cellular Antioxidative Defense Mechanisms
Reiter, R. J., Carneiro, R. C. G., & Oh, C. S. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979057 · Cited by 260 · see citing works
High melatonin solubility in aqueous medium
Shida, C. S., Castrucci, A. M. D. L., & Lamy, M. T. (1994) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1994.tb00102.x · Cited by 251 · see citing works
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.
Fernández-Checa, J. C., García‐Ruiz, C., Ookhtens, M., & Kaplowitz, N. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115010 · Cited by 242 · see citing works
Medical Uses of Vitamin E
Bieri, J. G., Corash, L., & Hubbard, V. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198305053081805 · Cited by 240 · see citing works
Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation
Voordouw, B. C., Euser, R., Verdonk, R. E., Alberda, B. T., de Jong, F. H., Drogendijk, A. C., Fauser, B. C. J. M., & Cohen, M. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.1.1727807 · Cited by 239 · see citing works
RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins.
Traber, M. G., Burton, G., Ingold, K. U., & Kayden, H. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42836-6 · Cited by 230 · see citing works
S-Adenosyl-L-Methionine
Friedel, H. A., Goa, K. L., & Benfield, P. (1989) · Drugs · doi:10.2165/00003495-198938030-00004 · Cited by 212 · see citing works
Antioxidant Actions of Melatonin
Reiter, R. J. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60981-3 · Cited by 195 · see citing works
Fetal Alcohol Syndrome: Current Status of Pathogenesis
Schenker, S., Becker, H. C., Randall, C. L., Phillips, D. K., Baskin, G. S., & Henderson, G. I. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb01220.x · Cited by 174 · see citing works
Self-citation
Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis
Frezza, M., Surrenti, C., Manzillo, G., Fiaccadori, F., Bortolini, M., & Padova, C. D. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91250-a · Cited by 155 · see citing works
Reversal of Intrahepatic Cholestasis of Pregnancy in Women after High Dose S-Adenosyl-L-Methionine Administration†
Frezza, M., Pozzato, G., Chiesa, L., Stramentinoli, G., & Padova, C. D. (1984) · Hepatology · doi:10.1002/hep.1840040217 · Cited by 138 · see citing works
Stereoisomers of alpha-tocopheryl acetate. II. Biopotencies of all eight stereoisomers, individually or in mixtures, as determined by rat resorption-gestation tests.
Weiser, H., & Vecchi, M. (1982) · PubMed · Cited by 134 · see citing works
Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport.
Wittmaack, F. M., Gåfvels, M. E., Bronner, M., Matsuo, H., McCrae, K. R., Tomaszewski, J. E., Robinson, S. L., Strickland, D. K., & Strauss, J. F. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828550 · Cited by 133 · see citing works
Transmethylation, transsulfuration, and aminopropylation reactions of S-adenosyl-L-methionine in vivo.
Giulidori, P., Galli-Kienle, M., Catto, E., et al. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43031-6 · Cited by 132 · see citing works
Multicenter trial of d-α-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis
Sokol, R. J., Butler–Simon, N., Conner, C. L., et al. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90652-s · Cited by 132 · see citing works
Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and wilson's disease
von Herbay, A., de GROOT, H., Hegi, U., Stremmel, W., Strohmeyer, G. W., & Sies, H. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80465-9 · Cited by 131 · see citing works
Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition
Bieri, J. G., & Evarts, R. P. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.9.980 · Cited by 131 · see citing works
Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition1
Bieri, J. G., & Evarts, R. P. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.8.980 · Cited by 130 · see citing works
In Utero Ethanol Exposure Elicits Oxidative Stress in the Rat Fetus
Henderson, G. I., Devi, B. G., Perez, A., & Schenker, S. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01572.x · Cited by 127 · see citing works
Self-citation
S -Adenosyl-L-methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: A randomized, double-blind, placebo-controlled study with negative results
Ribalta, J., Reyes, H., González, M. C., et al. (1991) · Hepatology · doi:10.1002/hep.1840130613 · Cited by 119 · see citing works
How melatonin interacts with lipid bilayers: a study by fluorescence and ESR spectroscopies
Costa, E. J. X., Shida, C. S., Biaggi, M. H., Ito, A. S., & Lamy, M. T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01178-2 · Cited by 113 · see citing works
Ethynylestradiol-induced impairment of bile secretion in the rat: Protective effects of S-Adenosyl-l-methionine and its implication in estrogen metabolism
Stramentinoli, G., Padova, C. D., Gualano, M. R., Rovagnati, P., & Galli-Kienle, M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90206-7 · Cited by 97 · see citing works
Transfer of Amino Acids across the In Vitro Perfused Human Placenta
Schneider, H., Kh, M., & Dancis, J. (1979) · Pediatric Research · doi:10.1203/00006450-197904000-00005 · Cited by 96 · see citing works
Effect of ethanol on rat fetal hepatocytes: Studies on cell replication, lipid peroxidation and glutathione
Devi, B. G., Henderson, G. I., Frosto, T. A., & Schenker, S. (1993) · Hepatology · doi:10.1002/hep.1840180325 · Cited by 96 · see citing works
Self-citation
Relative bioavailability of RRR- and all-rac-α-tocopheryl acetate in humans: studies using deuterated compounds
Acuff, R. V., THEDFORD, S. S., Hidiroglou, N., Papas, A., & Odom, T. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.3.397 · Cited by 96 · see citing works
Self-citation
Biodiscrimination of alpha-tocopherol stereoisomers in humans after oral administration
Kiyose, C., Muramatsu, R., Kameyama, Y., et al. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.3.785 · Cited by 84 · see citing works
Transport of deuterium-labeled tocopherols during pregnancy
Acuff, R. V., Dunworth, R., Webb, L., et al. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.459 · Cited by 83 · see citing works
Self-citation
Vitamin E Slows the Rate of Free Radical-Mediated Lipid Peroxidation in Cells
Wagner, B. A., Buettner, G. R., & Burns, C. P. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0454 · Cited by 81 · see citing works
Evidence for the Placental Transfer of 3H-Acetyl-Melatonin
Klein, D. C. (1972) · Nature New Biology · doi:10.1038/newbio237117a0 · Cited by 80 · see citing works
Diurnal Rhythms in Plasma Melatonin Concentrations in the Fetal Sheep and Pregnant Ewe during Late Gestation*
ZEMDEGS, I. Z., McMillen, I. C., WALKER, W., Thorburn, G. D., & Nowak, R. (1988) · Endocrinology · doi:10.1210/endo-123-1-284 · Cited by 79 · see citing works
Maternal pinealectomy abolishes the diurnal rhythm in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation
McMillen, I. C., & Nowak, R. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1200459 · Cited by 76 · see citing works
Vitamin E and vitamin E-quinone levels in red blood cells and plasma of newborn infants and their mothers.
Jain, S. K., Wise, R., & Bocchini Jr, J. A. (1996) · Journal of the American College of Nutrition · doi:10.1080/07315724.1996.10718563 · Cited by 66 · see citing works
4–Hydroxynonenal Levels Are Enhanced in Fetal Liver Mitochondria By In Utero Ethanol Exposure
Chen, J. J., Schenker, S., & Henderson, G. I. (1997) · Hepatology · doi:10.1002/hep.510250126 · Cited by 58 · see citing works
Self-citation
Pre- and postpartum supplemental DL-α-tocopheryl acetate effects on placental and mammary vitamin E transfer in sheep
Njeru, C., McDowell, L. R., Wilkinson, N. S., et al. (1994) · Journal of Animal Science · doi:10.2527/1994.7261636x · Cited by 54 · see citing works
Placental Function in Maternal-Fetal Fat Transport in Diabetes
Shafrir, E., & Barash, V. (2009) · Biology of the Neonate · doi:10.1159/000242639 · Cited by 54 · see citing works
Synthesis and secretion of apolipoprotein E by human placenta and choriocarcinoma cell lines
Rindler, M. J., Traber, M. G., Esterman, A. L., Bersinger, N. A., & Dancis, J. (1991) · Placenta · doi:10.1016/0143-4004(91)90496-3 · Cited by 51 · see citing works
Distribution of tocopherol among human plasma lipoproteins
Ogihara, T., Miki, M., 北川, 真., et al. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90056-3 · Cited by 51 · see citing works
Human placental transport of cimetidine.
Schenker, S., Dicke, J. M., Johnson, R. F., et al. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113222 · Cited by 49 · see citing works
Self-citation
Pharmacokinetics and Bioavailability of the RRR and All Racemic Stereoisomers of Alpha‐Tocopherol in Humans After Single Oral Administration
Ferslew, K. E., Acuff, R. V., Daigneault, E. A., et al. (1993) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1993.tb03909.x · Cited by 45 · see citing works
Self-citation
Effect of Acute Ethanol Exposure on Cultured Fetal Rat Hepatocytes: Relation to Mitochondrial Function
Devi, B. G., Henderson, G. I., Frosto, T. A., et al. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01447.x · Cited by 43 · see citing works
Self-citation
The effect of melatonin on cleavage rate of C57BL/6 and CB A/Ca preimplantation embryos cultured in vitro
McElhinny, A., Davis, F. C., & Warner, C. M. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00269.x · Cited by 42 · see citing works
Red blood cell vitamin E concentrations in fetuses are related to but lower than those in mothers during gestation
Cachia, O., Léger, C., Boulot, P., et al. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90167-1 · Cited by 42 · see citing works
FETAL AND MATERNAL RELATIONSHIP IN SERUM VITAMIN E LEVEL
Mino, M., & Nishino, H. (1973) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.19.475 · Cited by 40 · see citing works
Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy.
Overbergh, L., Lorent, K., Torrekens, S., Leuven, F. V., & BERGHE, H. V. D. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41496-8 · Cited by 37 · see citing works
Ethanol-induced oxidative stress and enzymatic defenses in cultured fetal rat hepatocytes
Devi, B. G., Schenker, S., Mazloum, B., et al. (1996) · Alcohol · doi:10.1016/0741-8329(96)00002-x · Cited by 34 · see citing works
Self-citation
Plasma 6-Hydroxymelatonin, 6-Sulfatoxymelatonin and Melatonin Kinetics after Melatonin Administration to Rats
Raynaud, F. I., Mauviard, F., Geoffriau, M., et al. (1993) · Neurosignals · doi:10.1159/000109516 · Cited by 32 · see citing works
Thiamine-transfer by human placenta: normal transport and effects of ethanol.
Schenker, S., Rf, J., Hoyumpa, A. M., et al. (1990) · PubMed · Cited by 30 · see citing works
Self-citation
Amidopyrine disposition in rat
Lockwood, G. F., & Houston, J. B. (1979) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1979.tb13661.x · Cited by 29 · see citing works
Development of pre-implantation, mouse embryos under the influence of pineal indoles
Chan, W. Y., & Ng, T. B. (1994) · Journal of Neural Transmission · doi:10.1007/bf01277925 · Cited by 28 · see citing works
α-Tocopherol-binding protein in the cytosol of the human placenta
Gordon, M. J., Campbell, F., & Duttaroy, A. K. (1996) · Biochemical Society Transactions · doi:10.1042/bst024202s · Cited by 22 · see citing works
Changes induced by pineal indoles in post-implantation mouse embryos
Chan, W. Y., & Ng, T. B. (1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)00264-n · Cited by 12 · see citing works
Placental transfer and tissue distribution of vitamin e in pregnant rabbits
Bortolotti, A., Traina, G. L., Barzago, M. M., et al. (1990) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510110804 · Cited by 10 · see citing works

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Rhythms of life: circadian disruption and brain disorders across the lifespan
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Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt054 · Cited by 371 · see citing works

Authors: Schenker, S., Yang, Y., Perez, A., Acuff, R. V., Papas, A. M., Henderson, G., & Lee, M. P.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
East Tennessee State University (US)
Eastman Chemical Company (United States) (US)
Corresponding author: Schenker, S.
ORCID: Henderson, G.
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 1998-08
Volume: 17
Issue: 4
Pages: 159-167
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/s0261-5614(98)80052-6
OpenAlex: W2023658354
Cited by: 68
References: 66
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2014: 6 · 2013: 5 · 2012: 2
FWCI: 0.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA010114, R01 AA10114)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords: placental transfer, antioxidants, melatonin, S-adenosylmethionine, vitamin E, placental cotyledons, passive diffusion, antipyrine, L-glucose, term placenta
MeSH terms: Antioxidants, Biological Transport, Active, Female, Humans, Maternal-Fetal Exchange, Melatonin, Placenta, Pregnancy, S-Adenosylmethionine, Vitamin E, Fetal Alcohol Spectrum Disorders

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Antioxidant transport by the human placenta

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