The DOI matches its Crossref record; 33 of the 38 references it cites were found in a registry or an index.
Immunogenicity of combined hepatitis A and B vaccine in elderly persons
Abstract
More and more elderly people travel to areas where hepatitis A and B are endemic. Their immune system is less effective than in young persons. Therefore, it has to be insured that these travelers have protective immunity after vaccination. In a retrospective study we measured anti hepatitis virus (anti-HAV) and anti-HBs in elderly persons (N = 104, mean age 54 years) after combined hepatitis A/B vaccination under every-day conditions. After complete vaccination only 36 (34.6%) had antibodies against both viruses. Only 23 (29%) of 80 vaccinees older than 40 years were protected against hepatitis B and 52 (65%) against hepatitis A. The response to the vaccination decreased with increasing age. Vaccination against hepatitis B-but not against hepatitis A-was also influenced by the presence of chronic disease. After one booster 87% of the anti-HAV negative vaccinees developed protective anti-HAV antibodies. Anti-HBs can be expected in about 50% of the HBV negative vaccinees with every single booster. These results indicate that combined hepatitis A/B vaccination is not very effective in elderly persons. After complete vaccination their anti-HAV and anti-HBs antibodies have to be controlled to insure protection. In case of vaccination-failure boosters are very effective.
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“The immune system changes with age in nearly every aspect, generally resulting in a decline in pathogen immunity with increased age.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [4]
In the citing paper
“ageing is associated with high morbidity and mortality rates for various infections and significant reductions in vaccine efficacy1-6”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [4]
Citations
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Hepatitis C Virus Infection in the Elderly
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de Tai, S. M.-T., Arana-Calderón, C. A., & Aguirre-Quispe, W. (2021) · Vacunas · doi:10.1016/j.vacun.2021.07.004
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Monitoring of hepatitis B infection in the elderly population of eastern Iran
Pagheh, A. S., Alemzadeh, E., Nazar, E., Moodi, M., Sharifi, F., Miri‐Moghaddam, E., Rahimi, M. T., Mohammadi, S., & Ziaee, M. (2025) · Vacunas (English Edition) · doi:10.1016/j.vacune.2025.100373
Edelman, R., Deming, M. E., Toapanta, F. R., Heuser, M. D., Chrisley, L., Barnes, R. S., Wasserman, S. S., Blackwelder, W. C., Handwerger, B. S., Pasetti, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12211514
Travel vaccination in senior travelers: current evidence, challenges, and prevention
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Metadata
- Authors
- Wolters, B., Junge, U., Dziuba, S., & Roggendorf, M.
- Affiliations
- University of Duisburg-Essen (DE)
- Klinikum Bielefeld (DE)
- Corresponding author
- Roggendorf, Michael
- ORCID
- Roggendorf, Michael
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 21
- Issue
- 25-26
- Pages
- 3623-3628
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W1980161689
- Cited by
- 116
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 10
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- immunogenicity, older adults, anti-HAV antibodies, anti-HBs antibodies, vaccine response, booster vaccination, vaccine failure, chronic disease, travel vaccination, age-related immune decline
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Health Status, Hepatitis B Surface Antigens, Humans, Immunization Schedule, Immunization, Secondary, Male, Middle Aged, Retrospective Studies, Hepatitis B Vaccines, Vaccines, Combined, Hepatitis A Vaccines, Hepatitis A Antibodies
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