The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid
Abstract
Free radicals or reactive oxygen species are thought to contribute to the pathology of many diseases. These include inflammatory conditions, where neutrophils accumulate in large numbers and are stimulated to produce superoxide and other reactive oxidants. Hypochlorous acid (HOCl), produced by myeloperoxidase-catalysed oxidation of chloride by hydrogen peroxide, is the major strong oxidant generated by these cells. Neutrophil-mediated injury may also be important in toxicology when an initial insult is followed by an inflammatory response. It is important to characterize the inflammatory component of such injury and the extent to which it involves reactive oxidants. On the one hand, this requires an understanding of how neutrophil oxidants react with cells and tissue constituents. On the other, specific biomarkers are needed so that oxidative damage can be quantified in clinical material and related to disease severity. This presentation considers biologically relevant reactions of HOCl and the biomarker assays that can be applied to probing the pathological role of myeloperoxidase and its products.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These inhibitors do not have a noticeable effect on XO- or eNOS-dependent ROS production, so they can be considered specific pan-NOX inhibitors.”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1016]
Citations
Cites
Inflammation. Basic principles and clinical correlates
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388
Hazen, S. L., & Heinecke, J. W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119379 · Cited by 842
Protein Carbonyl Measurement by a Sensitive ELISA Method
Buss, H., Chan, T., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00104-4 · Cited by 687
Self-citationInflammation: Basic Principles and Clinical Correlates
Ehrlich, G. E. (2000) · JAMA · doi:10.1001/jama.283.1.123 · Cited by 621
Presence of hypochlorite-modified proteins in human atherosclerotic lesions.
Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118576 · Cited by 592
Winterbourn, C. C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90120-5 · Cited by 463
Self-citationPeskin, A. V., & Winterbourn, C. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00506-2 · Cited by 335
Self-citationChlorination of Tyrosyl Residues in Peptides by Myeloperoxidase and Human Neutrophils
Domigan, N. M., Charlton, T. S., Duncan, M. W., Winterbourn, C. C., & Kettle, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16542 · Cited by 330
Self-citationHazell, L. J., van den Berg, J. J. M., & Stocker, R. (1994) · Biochemical Journal · doi:10.1042/bj3020297 · Cited by 267
Chlorohydrin Formation From Unsaturated Fatty Acids Reacted With Hypochlorous Acid
Winterbourn, C. C., van den Berg, J. J. M., Roitman, E., & Kuypers, F. A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90609-z · Cited by 258
Self-citationMyeloperoxidase and protein oxidation in cystic fibrosis
van der Vliet, A., Nguyen, M. N., Shigenaga, M. K., Eiserich, J. P., Marelich, G. P., & Cross, C. E. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l537 · Cited by 203
Neutrophils convert tyrosyl residues in albumin to chlorotyrosine
Kettle, A. J. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01494-2 · Cited by 187
Winterbourn, C. C., & Brennan, S. O. (1997) · Biochemical Journal · doi:10.1042/bj3260087 · Cited by 147
Self-citationHeinecke, J. W., Li, W., Mueller, D. M., Bohrer, A., & TURK, J. W. (1994) · Biochemistry · doi:10.1021/bi00199a041 · Cited by 141
Immunological evidence for hypochlorite-modified proteins in human kidney.
Malle, E., Woenckhaus, C., Waeg, G., Esterbauer, H., Gröne, E. F., & Gröne, H. (1997) · Europe PMC (PubMed Central) · Cited by 127
Pathways of phospholipid oxidation by HOCl in human LDL detected by LC-MS
Jerlich, A., Pitt, A. R., Schaur, R. J., & Spickett, C. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00273-7 · Cited by 110
Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid
Carr, A. C., & Winterbourn, C. C. (1997) · Biochemical Journal · doi:10.1042/bj3270275 · Cited by 108
Self-citationPullar, J. M., Winterbourn, C. C., & Vissers, M. C. M. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.4.h1505 · Cited by 102
Self-citationVissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999) · Biochemical Journal · doi:10.1042/bj3440443 · Cited by 95
Heinecke, J. W., Hsu, F., Crowley, J. R., Hazen, S. L., Leeuwenburgh, C., Mueller, D. M., RASMUSSEN, J. E., & TURK, J. W. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00121-4 · Cited by 94
Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102088200 · Cited by 91
Self-citationHypochlorous Acid Stimulation of the Mitogen-Activated Protein Kinase Pathway Enhances Cell Survival
Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2530 · Cited by 90
Self-citationCarr, A. C., Vissers, M. C. M., Domigan, N. M., & Winterbourn, C. C. (1997) · Redox Report · doi:10.1080/13510002.1997.11747122 · Cited by 75
Self-citationOn the Irreversible Destruction of Reduced Nicotinamide Nucleotides by Hypohalous Acids
Prütz, W. A., Kissner, R., Koppenol, W. H., & Rüegger, H. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1914 · Cited by 67
Chapman, A., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1744 · Cited by 65
Self-citationVile, G. F., Rothwell, L. A., & Kettle, A. J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1706 · Cited by 50
Cited by
Sorted by citations
Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,837
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K., Katayama, Y., Asoh, S., & Ohta, S. (2007) · Nature Medicine · doi:10.1038/nm1577 · Cited by 2,572
Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282
Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence
Niki, E. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.022 · Cited by 699
Yuan, L., Wang, L., Agrawalla, B. K., Park, S. J., Zhu, H., Balasubramaniam, S., Peng, J., Xu, Q., & Chang, Y. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b00042 · Cited by 557
Metadata
- Authors
- Winterbourn, C. C.
- Corresponding author
- Winterbourn, Christine C.
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 181-182
- Pages
- 223-227
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2065076024
- Cited by
- 247
- References
- 26
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 17 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 16 · 2013: 19 · 2012: 13
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- hypochlorous acid, neutrophils, myeloperoxidase, reactive oxygen species, oxidative stress, biomarkers, oxidative damage, inflammation, neutrophil-mediated injury, superoxide, hydrogen peroxide, biomarker assays
- MeSH terms
- Animals, Chlorohydrins, Humans, Hypochlorous Acid, Neutrophils, Oxidation-Reduction, Proteins, Sulfhydryl Compounds, Tyrosine, Biomarkers, Oxidants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
