Cited by 481Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Pharmacology and behavioral pharmacology of the mesocortical dopamine system

Tzschentke, T.M.·2001·Progress in Neurobiology

DOI 10.1016/s0301-0082(00)00033-2

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Abstract

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the knowledge about the function of this brain area and the role it plays in cognitive performance and behavioral output. In the first part, this review provides, from a pharmacological perspective, an overview of anatomical, electrophysiological and neurochemical aspects of the function of the PFC, with an emphasis on the mesocortical dopamine system. Anatomy of the mesocortical system, basic physiological and pharmacological properties of neurotransmission within the PFC, and interactions between dopamine and glutamate as well as other transmitters within the mesocorticolimbic circuit are included. The coverage of these data is largely restricted to what is relevant for the second part of the review which focuses on behavioral studies that have examined the role of the PFC in a variety of phenomena, behaviors and paradigms. These include reward and addiction, locomotor activity and sensitization, learning, cognition, and schizophrenia. Although the focus of this review is on the mesocortical dopamine system, given the intricate interactions of dopamine with other transmitter systems within the PFC and the importance of the PFC as a source of glutamate in subcortical areas, these aspects are also covered in some detail where appropriate. Naturally, a topic as complex as this cannot be covered comprehensively in its entirety. Therefore this review is largely limited to data derived from studies using rats, and it is also specifically restricted to data concerning the medial PFC (mPFC). Since in several fields of research the findings concerning the function or role of the mPFC are relatively inconsistent, the question is addressed whether these inconsistencies might, at least in part, be related to the anatomical and functional heterogeneity of this brain area.

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Handbook of Physiology.
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847

Show all 1,268 references

Research works printed but not linked: 50

Arvanitogiannis, 1997, Fos expression following self-stimulation of the medial prefrontal cortex, Soc. Neurosci. Abstr., 23, 2384
Bauco, 1994, Extracellular nucleus accumbens dopamine and metabolite levels during earned and unearned lateral hypothalamic brain stimulation, Soc. Neurosci. Abstr., 20, 823
Carr, G.D., Fibiger, H.C., Phillips, A.G., 1989. Conditioned place preference as a measure of drug reward. In: J.M. Liebman, S.J. Cooper (Eds.), The Neuropharmacological Basis of Reward. Clarendon Press, Oxford, pp. 264–319.
Carter, 1980, Glutamatergic pathways from the medial pre-frontal cortex to the anterior striatum, nucleus accumbens and substantia nigra, Br. J. Pharmacol., 70, 50
Carter, 1978, Studies on the roles of catecholamines in the frontal cortex, Br. J. Pharmacol., 62, 402P
Childress, 1996, Brain correlates of cue-induced and opiate craving, Soc. Neurosci. Abstr., 22, 365.5
Conover, 1992, Coactivation of the lateral hypothalamus and ventral tegmental area yields greater reward summation than coactivation of the lateral hypothalamus and medial pre-frontal cortex, Soc. Neurosci. Abstr., 18, 709
Di Chiara, 1992, Heterologous monoamine uptake: lack of transmitter specificity of neuron-specific carriers, Neurochem. Int., 20, 231S
Ditzler, 1991, Efficacy and tolerability of memantine in patients with dementia syndrome, Arzneimittelforschung/Drug Res., 8, 773
Douglin, 1979, Gradual increases in self-stimulation response rates: effect of electrode loci, Physiol. Behav., 7, 135
Feenstra, 1993, In vivo dopamine release in the rat prefrontal cortex is increased by stimulation of mediodorsal thalamic nucleus, Soc. Neurosci. Abstr., 19, 1382
Feenstra, 1995, Local application of a competitive NMDA antagonist in the medial prefrontal cortex increases in vivo DA but not NA release, Br. J. Pharmacol., 114, 328P
Forno, L.S., 1990. Pathology of Parkinson's disease: the importance of the substantia nigra and Lewy bodies. In: Stern, G. (Ed.), Parkinson's Disease. Chapman and Hall, London, pp. 185–238.
Fuster, J., 1980. The prefrontal cortex. Raven Press, New York.
Gabbott, 1996, Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: II. Quantitative arial and laminar distributions, J. Comp. Neurol., 364, 609, 10.1002/(SICI)1096-9861(19960122)364:4<609::AID-CNE2>3.0.CO;2-7 · DOI
Gillham, 1990, GABA neurons in the ventral tegmental area project to the medial prefrontal cortex: a non-dopaminergic mesocortical system, Soc. Neurosci. Abstr., 16, 105
Grace, 1984, Electrophysiology and morphology of four classes of prefrontal neocortical neurons studied in vitro, Soc. Neurosci. Abstr., 10, 739
Gresch, 1995, Stress-induced sensitization of dopamine and norepinephrine efflux in medial prefrontal cortex of the rat, J. Neurochem., 65, 575, 10.1046/j.1471-4159.1995.65010111.x · DOI
Hemby, 1990, Neuropharmacological assessment of cocaine-induced conditioned place preference using intra-cranial microinjections, Soc. Neurosci. Abstr., 16, 243.6
Hoffmann, 1986, Multiple effects of neuronal uptake inhibitors on transmitter release, J. Pharmacol. Exp. Ther., 238, 437
Koob, G.F., Goeders, N.E., 1989. Neuroanatomical substrates of drug self-administration. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 214–236.
Kuczenski, R., Segal, D.S., 1994. Neurochemistry of amphetamine. In: Cho, A., Segal, D.S. (Eds.), Amphetamine and its analogs. Academic Press, San Diego, pp. 81–113.
Kurata, 1993, Differential effects of tight and loose 2-h restraint stress on extracellular concentrations of dopamine in nucleus accumbens and anteromedial frontal cortex, Jpn. J. Psychiatry Neurol., 47, 57
Lindvall, O., Björklund, A., 1984. In: Descarries, L., Reader, T.R., Jasper, H.H. (Eds.), General organization of cortical monoamine systems. Liss, New York.
Lu, 1997, Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area, Synapse, 25, 205, 10.1002/(SICI)1098-2396(199702)25:2<205::AID-SYN11>3.0.CO;2-X · DOI
Moore, 1996, Interactions between amygdala and prefrontal cortical afferents to the nucleus accumbens and their modulation by dopamine receptor activation, Soc. Neurosci. Abstr., 22, 1088
Moore, R.Y., Card, J.P., 1984. Noradrenaline-containing neuron systems. In: Björklund, A., Hökfelt, T. (Eds.), Handbook of Chemical Neuroanatomy, vol. 2. Elsevier, Amsterdam, pp. 123–156.
Muly, 1997, D1 dopamine receptors are present in parvalbumine-positive interneurons in macaque prefrontal cortex, Soc. Neurosci. Abstr., 23, 1772
Nishijima, 1996, Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis, Synapse, 22, 304, 10.1002/(SICI)1098-2396(199604)22:4<304::AID-SYN2>3.0.CO;2-F · DOI
Nonneman, 1974, Comparisons of behavioral effects of hippocampal and prefrontal cortex lesions in the rat, J. Comp. Physiol. Psychol., 87, 249, 10.1037/h0036864 · DOI
Palkovits, M., 1979. Dopamine levels of individual brain regions: biochemical aspects of DA distribution in the central nervous system. Academic Press, London, pp. 343–356.
Phillips, A.G., Fibiger, H.C., 1989. Neuroanatomical bases of intracranial self-stimulation: untangling the Gordian knot. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 66–105.
Pickel, V.M., Sesack, S.M., 1995. Electron microscopy of central dopamine systems. In: Bloom, F.E., Kupfer, D.J. (Eds.), Psychopharmacology: The fourth generation of progress. Raven Press, New York, pp. 257–268.
Seamans, 1995, Selective impairment on a delayed radial arm task following local administration of a D1, but not a D2, antagonist into the prefrontal cortex, Soc. Neurosci. Abstr., 21, 1942
Shibata, 1990, Effect of dopamine agonists on locomotor activity of anteromedial frontal cortex lesioned rats, Jpn. J. Psychiatry Neurol., 44, 789
Shippenberg, 1993, Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D1 versus D2 dopamine receptors, J. Pharmacol. Exp. Ther., 265, 53
Simon, 1981, Dopaminergic A10 neurons and the frontal system, J. Physiol., 77, 81
Smiley, 1996, Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy, J. Comp. Neurol., 367, 431, 10.1002/(SICI)1096-9861(19960408)367:3<431::AID-CNE8>3.0.CO;2-6 · DOI
Smith, 1998, Microcircuitry of the direct and indirect pathways of the basal ganglia, Neuroscience, 86, 353
Stellar, J.R., Rice, M.B., 1989. Pharmacological basis of intracranial self-stimulation reward. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 14–65.
Taylor, 1978, Comparison of monoamine uptake by cocaine, methylphenidate and amphetamine, Res. Commun. Pathol. Pharmacol., 21, 67
Thierry, A.M., Tassin, J.P., Blanc, G., Glowinski, J., 1976b. Topographical and pharmacological study of the mesocortical dopaminergic systems. In: Wauqnier, A., Rolls, E.T. (Eds.), Brain Stimulation Reward. North-Holland, Amsterdam, pp. 290–293.
Tzschentke, 1997, Electrical stimulation of the medial prefrontal cortex elicits release of dopamine and glutamate in nucleus accumbens and ventral tegmental area in rats: effects of different frequencies and currents, Soc. Neurosci. Abstr., 23, 1753
Tzschentke, T.M., Schmidt, W.J., 1998b. Functional heterogeneity of the medial prefrontal cortex and its relevance for drug reward. On-line Proceedings of the Fifth Internet World Congress on Biomedical Sciences (INABIS)’ 98 at McMaster University, Canada (available from URL: http://www.mcmaster.ca/inabis98/).
Uylings, H.B.M., van Eden, C.G., De Bruin, J.P.C., Corner, M.A., Feenstra, M.G.P. (Eds.), 1990. The prefrontal cortex—its structure, function and pathology. Progress in Brain Research, vol. 85. Elsevier, Amsterdam.
van Eden, 1997, Efferents from the rat medial prefrontal cortex can influence dopaminergic cells in the ventral tegmental area, which project to the nucleus accumbens, Soc. Neurosci. Abstr., 23, 1213
Weiner, 1990, Disruption of latent inhibition by a low dose of amphetamine is antagonised by haloperidol and apomorphine, J. Psychopharmacol., 4, 255
White, F.J., Wachtel, S.R., Johansen, P.A., Einhorn, L.C., 1987. Electrophysiological studies of the rat mesoaccumbens dopamine systems: focus on dopamine receptor subtypes, interactions, and the effect of cocaine. In: Chiodo, L.A., Freeman, F.A. (Eds.), Neurophysiology of dopaminergic systems: current status and clinical perspectives. Lakeshore, Detroit, pp. 317–365.
White, F.J., Hu, X.T., Henry, D.J., Zhang, X.F., 1995a. Neurophysiological alterations in the mesocorticolimbic dopamine system with repeated cocaine administration. In: Hammer Jr, R.P. (Ed.), The Neurobiology of Cocaine: Cellular and Molecular Mechanisms. CRC Press, Boca Raton, FL, pp. 99–119.
Yang, 1996, Focal dendritic D1 receptor stimulation differentially modulates layers I-II and V-VI glutamate inputs to deep layer prefrontal cortical pyramidal neurons in vitro, Soc. Neurosci. Abstr., 22, 1770

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Sofuoglu, M., Waters, A. J., Mooney, M. E., & Kosten, T. R. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.05.003 · Cited by 21
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Dunčko, R. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00164-3 · Cited by 21
Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex
Campanac, E., & Hoffman, D. A. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00596.2012 · Cited by 20
Neurotensin: an endogenous psychostimulant?
Bérod, A. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00127-8 · Cited by 20
Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats
Varatharajan, R., Joseph, K., Neto, S. C., Hofmann, U., Moser, A., & Tronnier, V. M. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.002 · Cited by 19
Differential Modulation of Ventral Tegmental Area Circuits by the Nociceptin/Orphanin FQ System
Driscoll, J. R., Wallace, T. L., Mansourian, K. A., Martin, W. J., & Margolis, E. B. (2020) · eNeuro · doi:10.1523/eneuro.0376-19.2020 · Cited by 19
Tiagabine affects the subjective responses to cocaine in humans
Sofuoglu, M., Poling, J. C., Mitchell, E., & Kosten, T. R. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.10.013 · Cited by 19
Effect of GBR12909 on affective behavior: Distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation
Esumi, S., Sagara, H., Nakamoto, A., Kawasaki, Y., Gomita, Y., & Sendo, T. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.051 · Cited by 19
Verbal but not performance IQ is highly correlated to externalizing behavior in boys with ADHD carrying both DRD4 and DAT1 risk genotypes
Kébir, O., Grizenko, N., Sengupta, S. M., & Joober, R. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.019 · Cited by 19
Alterations in amphetamine‐stimulated dopamine overflow due to the Nurr1‐null heterozygous genotype and postweaning isolation
Moore, T. M., Brown, T., Cade, M., & Eells, J. B. (2008) · Synapse · doi:10.1002/syn.20550 · Cited by 18
Attenuation of MK-801-induced behavioral perseveration by typical and atypical antipsychotic pretreatment in rats.
Tuplin, E. W. N., Stocco, M. R., & Holahan, M. R. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000066 · Cited by 18
Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences
McDougall, S. A., Rios, J. W., Apodaca, M. G., Park, G. I., Montejano, N. R., Taylor, J. A., Moran, A. E., Robinson, J. A. M., Baum, T. J., Teran, A., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112302 · Cited by 18
Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease
Ward, K. R., Featherstone, R. E., Naschek, M. J., Melnychenko, O., Banerjee, A., Yi, J., Gifford, R. L., Borgmann‐Winter, K. E., Salter, M. W., Hahn, C.-G., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.02.017 · Cited by 18
The Roles of Dopamine
Suri, R. E., & Fellous, J. (2003) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-007584838 · Cited by 18
Dopamine Mechanisms and Cocaine Reward
Ikegami, A., & Duvauchelle, C. L. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)62002-2 · Cited by 18
Effects of Cocaine Administration on VTA Cell Activity in Response to Prefrontal Cortex Stimulation
ALMODÓVAR‐FÁBREGAS, L. J., Segarra, O., Colon, N., DONES, J. G., MERCADO, M., Mejías-Aponte, C. A., VÁZQUEZ, R., Abreu, R., Vázquez, E., Williams, J. T., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04158.x · Cited by 18
Intra-prefrontal cortex injections of SCH 23390 influence nucleus accumbens dopamine levels 24 h post-infusion
Olsen, C. M., & Duvauchelle, C. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03152-3 · Cited by 18
Does dopamine sensitization underlie the association between schizophrenia and drug abuse?
Tsapakis, E., Guillin, O., & Murray, R. (2003) · Current Opinion in Psychiatry · doi:10.1097/00001504-200304002-00008 · Cited by 22
Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat
Hernández, L. F., Segovia, G., & Mora, F. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.005 · Cited by 17
Dopamine-Glutamate Interactions in Reward-Related Incentive Learning
Beninger, R. J., & Gerdjikov, T. V. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_14 · Cited by 17
Kainic acid lesion-induced spatial memory deficits of rats
Hriţcu, L., & Nabeshima, T. (2009) · Open Life Sciences · doi:10.2478/s11535-009-0001-9 · Cited by 17
Spontaneous individual differences in cognitive performances of young adult rats predict locomotor response to amphetamine
Dellu-Hagedorn, F. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.07.002 · Cited by 17
Ultrastructural localization of Leu 5 ‐enkephalin immunoreactivity in mesocortical neurons and their input terminals in rat ventral tegmental area
Garzón, M., & Pickel, V. M. (2004) · Synapse · doi:10.1002/syn.20000 · Cited by 17
Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits
Sun, M., Zhang, Y., Zhang, X., Zhang, Y., Wang, X., Li, J., Si, T., & Su, Y. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01866-7 · Cited by 16
Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells
Jiang, L., O’Leary, C., Kim, H. A., Parish, C. L., Massalas, J. S., Waddington, J. L., Ehrlich, M. E., Schütz, G., Gantois, I., Lawrence, A. J., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.006 · Cited by 16
Theta–gamma coupling in the prelimbic area is associated with heroin addiction
Zhu, Z., Ye, Z., Wang, H., Hua, T., Wen, Q., & Zhang, C. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.02.020 · Cited by 16
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Kalló, I., Omrani, A., Meye, F. J., de Jong, H., Liposits, Z., & Adan, R. A. H. (2022) · Brain Structure and Function · doi:10.1007/s00429-021-02449-8 · Cited by 15
Electrical stimulation of the ventral tegmental area exerts opposite effects on male rat sexual behaviour expression depending on the stimulated sub region
Rodrı́guez–Manzo, G., & Pellicer, F. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.02.006 · Cited by 16
Efavirenz exposure, alone and in combination with known drugs of abuse, engenders addictive-like bio-behavioural changes in rats
Möller, M., Fourie, J., & Harvey, B. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-29978-3 · Cited by 15
Involvement of the dopaminergic system in the reward-related behavior of pregabalin
Althobaiti, Y. S., Almutairi, F. M., Alshehri, F. S., Altowairqi, E., Marghalani, A. M., Alghorabi, A. A., Alsanie, W. F., Gaber, A., Alsaab, H. O., Almalki, A. H., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88429-8 · Cited by 15
D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality
Coppa-Hopman, R., Galle, J., & Pimkine, D. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108091256 · Cited by 15
Prenatal cocaine exposure enhances long-term potentiation induction in rat medial prefrontal cortex
Huang, C., Liang, Y., & Hsu, K. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000258 · Cited by 15
Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways
Cathala, A., Devroye, C., Robert, É., Vallée, M., Revest, J., Artigas, F., & Spampinato, U. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108309 · Cited by 15
Schizophrenia and Substance Abuse Co-Morbidity
O’Daly, O., Guillin, O., Tsapakis, E.-M., Martínez, D., Shergill, S. S., Murray, R. M., & Buckley, P. F. (2005) · Journal of Dual Diagnosis · doi:10.1300/j374v01n02_03 · Cited by 15
Effects of antipsychotic treatment on psychopathology and motor symptoms. A placebo-controlled study in healthy volunteers
Veselinović, T., Schorn, H., Vernaleken, I., Schiffl, K., Hiemke, C., Zernig, G., Gur, R. C., & Gründer, G. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2368-3 · Cited by 15
Toluene Inhalation Increases Extracellular Noradrenaline and Dopamine in the Medial Prefrontal Cortex and Nucleus Accumbens in Freely-Moving Rats
Koga, Y., Higashi, S., Kawahara, H., & Ohsumi, T. (2007) · The Journal of the Kyushu Dental Society · doi:10.2504/kds.61.39 · Cited by 14
Post-pubertal adrenergic changes in rats with neonatal lesions of the ventral hippocampus
Bhardwaj, S. K., Quirion, R., & Srivastava, L. K. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.001 · Cited by 14
Discrimination: From behaviour to brain
Phillmore, L. S. (2007) · Behavioural Processes · doi:10.1016/j.beproc.2007.11.004 · Cited by 14
Anterior ventral tegmental area dopaminergic neurons are not involved in the motivational effects of bromocriptine, pramipexole and cocaine in drug-free rats
Ouachikh, O., Dieb, W., Durif, F., & Hafidi, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.021 · Cited by 14
Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats
Bouwmeester, H., Gerrits, M. A. F. M., Roozemond, J. G., Snapper, J., Ronken, E., Kruse, C. G., Westenberg, H. G. M., & van Ree, J. M. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706007346 · Cited by 14
Extraversion and the Dopamine Hypothesis
Rammsayer, T. H. (2004) · Elsevier eBooks · doi:10.1016/b978-008044209-9/50022-1 · Cited by 14
Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress
Solarz, A., Majcher‐Maślanka, I., Kryst, J., & Chocyk, A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00456-6 · Cited by 13
The role of NMDA receptors in rat propofol self-administration
Chen, B.-P., Huang, X., Dong, D.-M., Wu, H. B. K., Zhu, T., & Wang, B. (2020) · BMC Anesthesiology · doi:10.1186/s12871-020-01056-0 · Cited by 13
Environmental exposure to 17β-trenbolone during adolescence inhibits social interaction in male mice
Zhang, S., Jiao, Z., Zhao, X. J., Sun, M., & Feng, X. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117710 · Cited by 13
Differential role of serotonin projections from the dorsal and median raphe nuclei in phencyclidine‐induced hyperlocomotion and fos‐like immunoreactivity in rats
Kusljic, S., & van den Buuse, M. (2012) · Synapse · doi:10.1002/syn.21580 · Cited by 13
Glucose-monitoring neurons in the mediodorsal prefrontal cortex
Nagy, B., Szabó, I., Papp, S., Takács, G., Szalay, C., & Karádi, Z. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.025 · Cited by 13
The dopaminergic system plays a role in the effect of lithium on inhibitory avoidance memory in mice
Zarrindast, M., Misaghi, S., & Ahmadi, S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.009 · Cited by 13
Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine
Gaweł, K., Łabuz, K., Gibuła‐Tarłowska, E., Jenda, M., Marszałek‐Grabska, M., Silberring, J., & Kotlinska, J. H. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116642539 · Cited by 13
Verbal working memory and functional large-scale networks in schizophrenia
Dauvermann, M. R., Moorhead, T. W. J., Watson, A. R., Duff, B. J., Romaniuk, L., Hall, J., Roberts, N., Lee, G. L., Hughes, Z. A., Brandon, N. J., et al. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.10.004 · Cited by 12
Dopamine and Schizophrenia
Abi‐Dargham, A., & Grace, A. A. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch20 · Cited by 12
Complexity of VTA DA neural activities in response to PFC transection in nicotine treated rats
Chen, T. Y., Zhang, D., Dragomir, A., Akay, Y. M., & Akay, M. (2011) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-8-13 · Cited by 11
Assessment of the neuroprotective effect of green synthesized iron oxide nanoparticles capped with curcumin against a rat model of Parkinson's disease.
Khadrawy, Y. A., Hosny, E. N., & Mohamed, H. S. (2024) · PubMed Central · doi:10.22038/ijbms.2023.73124.15892 · Cited by 11
Modulation of Excitatory Transmission onto Midbrain Dopaminergic Neurons of the Rat by Activation of Group III Metabotropic Glutamate Receptors
Valenti, O., Marino, M. J., & Conn, P. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.058 · Cited by 11
l-Stepholidine increases the frequency of sEPSC via the activation of D1dopamine signaling pathway in rat prelimbic cortical neurons
Gao, M., Liu, C., Shen, Y. A. N. G., Xue-chu, Z. H. E. N., & Jin, G.-Z. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00547.x · Cited by 12
A simulation model for compensatory plasticity in the prefrontal cortex inducing a cortico-cortical dysconnection in early brain development
Butz, M., & Teuchert, G. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0403-4 · Cited by 12

Authors: Tzschentke, T. M.
Affiliations: Grünenthal Group (Germany) (DE)
Corresponding author: Tzschentke, T.M.
ORCID: Tzschentke, T.M.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2001-02
Volume: 63
Issue: 3
Pages: 241-320
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/s0301-0082(00)00033-2
OpenAlex: W2111304405
Semantic Scholar: 314205aef63746557803f0214ed764321bbe28dc
Cited by: 481
References: 1,268
Citations by year: 2026: 1 · 2025: 4 · 2024: 9 · 2023: 19 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 13 · 2018: 6 · 2017: 17 · 2016: 14 · 2015: 24 · 2014: 21 · 2013: 11 · 2012: 24
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mesocortical dopamine system, prefrontal cortex, medial prefrontal cortex, glutamate, dopamine-glutamate interaction, mesocorticolimbic circuit, reward, addiction, locomotor activity, sensitization, learning, cognition, schizophrenia
MeSH terms: Animals, Behavior, Animal, Dopamine, Humans, Synaptic Transmission, Neurons, Prefrontal Cortex, Ventral Tegmental Area

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Pharmacology and behavioral pharmacology of the mesocortical dopamine system

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