The PTX family of homeodomain transcription factors during pituitary developments
Abstract
A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes. We isolated the first member of this family, Ptxl (pituitary homeobox 1), through its DNA binding properties whereas a second related gene, Ptx2 (RIEG), was identified by positional cloning as the causative gene for Rieger's syndrome. The mechanisms of Ptx action on its target genes as well as its putative roles during development are reviewed with particular emphasis on its role in pituitary function.
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rs133934508 (menarche P=3.6×10−5) is associated with expression of PITX1, which encodes a pituitary transcriptional regulator.
“rs133934508 (menarche P-value=3.6×10−5) is associated with expression of PITX1, which encodes a pituitary transcriptional regulator30.”
From Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) · cites this paper as [30]
Cites
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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
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A Single Pitx1 Binding Site Is Essential for Activity of the LHβ Promoter in Transgenic Mice
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- Authors
- Drouin, J., Lamolet, B., Lamonerie, T., Lanctôt, C., & Tremblay, J. J.
- Affiliations
- Montreal Clinical Research Institute (CA)
- Corresponding author
- Drouin, Jacques
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 140
- Issue
- 1-2
- Pages
- 31-36
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2072604483
- Cited by
- 114
- References
- 15
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- homeodomain transcription factor, pituitary development, positional cloning, DNA binding, pituitary function
- MeSH terms
- Homeobox Protein PITX2, Animals, DNA-Binding Proteins, Multigene Family, Humans, Nuclear Proteins, Pituitary Gland, Transcription Factors, Transcriptional Activation, Trans-Activators, Homeodomain Proteins, Gene Expression Regulation, Developmental, Response Elements, Drosophila Proteins, Paired Box Transcription Factors
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