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Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng
Open accessAbstract
Heat treatment of Panax ginseng C.A. Meyer at a temperature higher than that applied to the conventional preparation of red ginseng yielded a mixture of saponins with potent antioxidative properties. Thus, the methanol extract of heat-processed neoginseng (designated as 'NGMe') attenuated lipid peroxidation in rat brain homogenates induced by ferric ion or ferric ion plus ascorbic acid. Furthermore, the extract protected against strand scission in phiX174 supercoiled DNA induced by UV photolysis of H2O2, and was also capable of scavenging superoxide generated by xanthine-xanthine oxidase or by 12-O-tetradecanoylphorbol-13-acetate (TPA) in differentiated human promyelocytic leukemia (HL-60) cells. Topical application of NGMe onto shaven backs of female ICR mice 10 min prior to TPA, significantly ameliorated skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene. Moreover, TPA-induced enhancement of epidermal ornithine decarboxylase (ODC) activity and ODC mRNA expression was abolished by a topical dose (0.68 mg) of NGMe. Likewise, TPA-induced production of tumor necrosis factor- in mouse skin was inhibited by NGMe pretreatment.
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Cited by
Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity
Yang, W.-Z., Hu, Y., Wu, W.-Y., Ye, M., & Guo, D.-A. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.07.012 · Cited by 342
Toxicity of Naturally Occurring Anthraquinones
Shukla, V., Asthana, S., Gupta, P., Dwivedi, P. D., Tripathi, A., & Das, M. (2017) · Advances in Molecular Toxicology · doi:10.1016/b978-0-12-812522-9.00001-4 · Cited by 42
Shin, S., Lee, J.-A., Son, D., Park, D., & Jung, E. (2017) · Cosmetics · doi:10.3390/cosmetics4020018 · Cited by 34
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Metadata
- Authors
- Keum, Y.-S., Park, K.-K., Lee, J.-M., Chun, K.-S., Park, J. H., Lee, S. K., Kwon, H., & Surh, Y.-J.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 150
- Issue
- 1
- Pages
- 41-48
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2122579696
- Cited by
- 379
- References
- 0
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Keum, Y.-S., Park, K.-K., Lee, J.-M., Chun, K.-S., Park, J. H., Lee, S. K., Kwon, H., & Surh, Y.-J. (2000). Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Letters. https://doi.org/10.1016/s0304-3835(99)00369-9
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