Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer
Open accessAbstract
Ginseng leaves contain high saponin composition and content, but are used less often than the root part. To develop a use for the leaves that exploits their properties, we studied ginseng leaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular factivity and clinical efficacy of ginseng leaf extract, providing necessary information relevant to the development of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown to have high contents of Rb3 and Rb2. Rb3, the major chemical components of PGLE, promoted collagen synthesis though the activation of transforming growth factor-β (TGF-β) in human skin fibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clinically validated. Our analysis of the crow’s feet wrinkle showed that there was a decrease in the depth of deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period. Based on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered as an attractive, wrinkle-reducing candidate for topical application.
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P. ginseng exerts protective effects against skin aging by reducing inflammation and stimulating collagen synthesis, as demonstrated in in vitro and in vivo models.
“Numerous pharmacological studies have confirmed that P. ginseng exerts protective effects against skin aging by mechanisms such as reducing inflammation and stimulating collagen synthesis, as demonstrated through both in vitro and in vivo experimental models [10,11,12,13,14].”
From Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage (2024) · cites this paper as [14]
The Abstract (page unavailable) reports that a purified P. ginseng leaf extract promoted collagen synthesis in human skin fibroblasts and that a lotion containing the extract reduced crow’s-feet wrinkle depth in volunteers. The Discussion (page unavailable) likewise describes its potential anti-skin-aging effects. Neither passage supports reducing inflammation as a mechanism, so this source supports only part of the attributed claim. (LLM, conf=0.88)
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- Authors
- Shin, S., Lee, J.-A., Son, D., Park, D., & Jung, E.
- Affiliations
- Biospectrum Life Science Institute, U-TOWER 18th FL, 767, Sinsu Ro, Suji Gu, Yongin City, Gyunggi Do 16827, Korea
- Corresponding author
- Jung, Eunsun
- Venue
- Cosmetics
- Publisher
- MDPI AG
- Published
- 2017-06-01
- Volume
- 4
- Issue
- 2
- Pages
- 18
- ISSN
- 2079-9284 (ISSN-L)
- OpenAlex
- W2617448070
- Cited by
- 34
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cosmetics (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Korean Ministry of Health and Welfare (HI15C0050)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- Panax ginseng, anti-aging cosmetics, skin aging, collagen synthesis, RB3, Rb2, saponins, TGF-beta, human dermal fibroblasts, wrinkle reduction, topical application
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