Microscale electrostatics in mitosis
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The applied field is expected to interfere with proper microtubule formation preventing a functioning mitotic spindle, due to the force of interactions with the large intrinsic dipole moments of the tubulin dimers.
“the applied field is expected to interfere with proper microtubule (MT) formation preventing a functioning mitotic spindle, due to the force of interactions with the large intrinsic dipole moments of the tubulin dimers [14,15,16]”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [16]
The authors of references [15,16,22] estimated the maximum electrostatic force in the mitotic plate as F = 6n2 pN per MT where n is the number of elementary charges on each protofilament.
“The authors of the references [15,16,22] estimated the maximum electrostatic force in the mitotic plate, which was given as F = 6n2 pN per MT where n is the number of elementary charges on each protofilament.”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [16]
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Flagged first, then by citations
2 of the 34 references couldn’t be matched to a known paper.
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Wenger, C., Miranda, P. C., Salvador, R., Thielscher, A., Bomzon, Z., Giladi, M., Mrugala, M. M., & Korshoej, A. R. (2018) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2017.2765282 · Cited by 126 · see citing works
“influence chromosomal motion [65]–[67].”
Nonlinear ionic pulses along microtubules
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An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields
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Li, X., Liu, K., Xing, L., & Rubinsky, B. (2023) · Radiology and Oncology · doi:10.2478/raon-2023-0044 · Cited by 43 · see citing works
Is intracellular pH a clock for mitosis?
Gagliardi, L. J., & Shain, D. H. (2013) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-10-8 · Cited by 34 · see citing works
“Thus it seems reasonable to assume that, over distances consistent with the reduced dielectric constant and modified counterion screening, the electrostatic nature of tubulin dimers allows tubulin dimer microtubule subunits to align end-to-end and laterally, facilitating the formation of asters and mitotic spindles [2…”
BackgroundSelf-citationGagliardi, L. J. (2002) · Physical Review E · doi:10.1103/physreve.66.011901 · Cited by 33 · see citing works
Self-citationElectrostatic force generation in chromosome motions during mitosis
Gagliardi, L. J. (2005) · Journal of Electrostatics · doi:10.1016/j.elstat.2004.09.007 · Cited by 26 · see citing works
Self-citationElectrostatic considerations in nuclear envelope breakdown and reassembly
Gagliardi, L. J. (2006) · Journal of Electrostatics · doi:10.1016/j.elstat.2006.02.005 · Cited by 11 · see citing works
Self-citationElectrostatic forces drive poleward chromosome motions at kinetochores
Gagliardi, L. J., & Shain, D. H. (2016) · Cell Division · doi:10.1186/s13008-016-0026-1 · Cited by 8 · see citing works
“Thus dipole electrostatic fields organize and align electric dipole dimer subunits, thereby facilitating their assembly into microtubules that form the asters and the mitotic spindle [46].”
BackgroundSelf-citationPolar electrostatic forces drive poleward chromosome motions
Gagliardi, L. J., & Shain, D. H. (2014) · Cell Division · doi:10.1186/s13008-014-0005-3 · Cited by 8 · see citing works
“, the centrosome matrix within which the microtubule dimer dipolar subunits assemble in many cell types to form asters [25]) was proposed to carry a net negative charge [2,26].”
BackgroundSelf-citationInduced electrostatic charge in poleward motion of chromosomes during mitosis
Gagliardi, L. J. (2007) · Journal of Electrostatics · doi:10.1016/j.elstat.2007.11.002 · Cited by 7 · see citing works
Self-citationHow pH deregulation favors the hallmarks of cancer
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Electrical oscillations in microtubules
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“Given that MT oscillation frequencies overlap (among others, Scarinci et al., 2023[6]) with the gamma range of neuronal activity (30–100 Hz), it is plausible that MT-based electrodynamics contribute to synchronization phenomena underlying higher-order brain functions.”
Emergent Mitotic Chromosome Motions from a Changing Intracellular pH
Gagliardi, L. J., & Shain, D. H. (2017) · Open Journal of Biophysics · doi:10.4236/ojbiphy.2018.81002 · Cited by 2 · see citing works
“This is consistent with the efficient self-assembly of the spindle during prophase, when—due to the higher pHi—the greater expression of negative charge on tubulin dimers (notably C-termini) and centrosomes favors microtubule polymerization and microtubule organizing center nucleation [20] [26].”
BackgroundSelf-citationContinuum Electrostatics in Cell Biology
Gagliardi, L. J. (2010) · NeuroQuantology · doi:10.14704/nq.2010.8.3.299 · Cited by 1 · see citing works
Self-citationSystems Approach to Mitotic Chromosome Motions
Gagliardi, L. J. (2013) · Open Journal of Biophysics · doi:10.4236/ojbiphy.2013.32017
Self-citation
- Authors
- Gagliardi, L. J.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Gagliardi, L.J.
- ORCID
- Gagliardi, L.J.
- Venue
- Journal of Electrostatics
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 54
- Issue
- 3-4
- Pages
- 219-232
- ISSN
- 0304-3886 (ISSN-L)
- OpenAlex
- W2163584069
- Cited by
- 17
- References
- 34
- Citations by year
- 2025: 1 · 2023: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 3
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Electrostatics (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- mitosis, microtubules, electric dipole, ionic screening, Debye length, ASTER, anaphase A, anaphase B, cell elongation, intracellular pH, cytokinesis, cell division mechanism
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