High-voltage-activated Ca2+ currents and the excitability of pyramidal neurons in the hippocampal CA3 subfield in rats depend on corticosterone and time of day
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This study tested the time-of-day dependence of the intrinsic postsynaptic properties of hippocampal CA3 pyramidal neurons. High-voltage-activated Ca2+ currents and the Ca(2+)- and voltage-dependent afterhyperpolarizations were examined in slices of rat brains obtained at four distinct time periods. Just after onset of the dark phase, the steady-state amplitude of the Ca2+ current (-1.24+/-0.11 nA) was significantly greater (P<0.03) than that of the light phase (-0.84+/-0.06 nA). Over the entire time range, the amplitude of the Ca2+ current correlated with plasma corticosterone levels in a U-shaped function. Furthermore, depolarization-induced excitability during the dark phase exhibited an increased spike after depolarization (3.1+/-0.1 mV) and a slower adaptation of the firing frequency (146+/-18%). These findings point to a dynamic time-of-day dependence of the CA3 neuronal properties and postsynaptic Ca2+ currents.
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The rapid stress-induced activation of the hippocampus by steroidal and nonsteroidal neuromodulators would produce a dramatic increase in intracellular calcium levels.
“Ultimately, the rapid stress-induced activation of the hippocampus by steroidal and nonsteroidal neuromodulators would produce a dramatic increase in intracellular calcium levels (Kole et al. [256]; Joëls [257]; Joëls et al. [258]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Kole et al. [256]
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- Authors
- Kole, M. H. P., Koolhaas, J. M., Luiten, P. G. M., & Fuchs, E.
- Affiliations
- University of Groningen (NL)
- German Primate Center (DE)
- Corresponding author
- Fuchs, Eberhard
- ORCID
- Kole, Maarten H.P
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 307
- Issue
- 1
- Pages
- 53-56
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2044312381
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- high-voltage-activated calcium current, hippocampal CA3 pyramidal neurons, corticosterone, circadian rhythm, time of day, afterhyperpolarization, neuronal excitability, plasma corticosterone
- MeSH terms
- Action Potentials, Animals, Cadmium, Cell Membrane, Circadian Rhythm, Corticosterone, Hippocampus, Male, Neural Inhibition, Calcium Channels, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Rats
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