Cited by 166Circadian rhythm and melatoninMemory and Neural MechanismsSleep and Wakefulness Research

A time to remember: The role of circadian clocks in learning and memory.

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Smarr, Benjamin L., Jennings, Kimberly J., Driscoll, Joseph R., Kriegsfeld, Lance J.·2014·Behavioral Neuroscience

Abstract

The circadian system has pronounced influence on learning and memory, manifesting as marked changes in memory acquisition and recall across the day. From a mechanistic perspective, the majority of studies have investigated mammalian hippocampal-dependent learning and memory, as this system is highly tractable. The hippocampus plays a major role in learning and memory, and has the potential to integrate circadian information in many ways, including information from local, independent oscillators, and through circadian modulation of neurogenesis, synaptic remodeling, intracellular cascades, and epigenetic regulation of gene expression. These local processes are combined with input from other oscillatory systems to synergistically augment hippocampal rhythmic function. This overview presents an account of the current state of knowledge on circadian interactions with learning and memory circuitry and provides a framework for those interested in further exploring these interactions.

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Authors
Smarr, B. L., Jennings, K. J., Driscoll, J. R., & Kriegsfeld, L. J.
Affiliations
University of California System (US)
Venue
Behavioral Neuroscience
Published
2014
Volume
128
Issue
3
Pages
283-303
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2119461571
Cited by
166
References
248
Citations by year
2026: 5 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 23 · 2021: 19 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 6
FWCI
6.33
Type
journal article
Language
en
Open access
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders
National Institutes of Health (R01 HD050470)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
circadian clock, learning, memory, hippocampus, circadian rhythm, memory consolidation, synaptic plasticity, epigenetic regulation, local oscillator, hippocampal-dependent memory
MeSH terms
Animals, Circadian Rhythm, Hippocampus, Learning, Memory, Synapses, Long-Term Potentiation, Epigenesis, Genetic, Neurogenesis, Circadian Rhythm Signaling Peptides and Proteins, Circadian Clocks

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