A time to remember: The role of circadian clocks in learning and memory.
Open accessAbstract
The circadian system has pronounced influence on learning and memory, manifesting as marked changes in memory acquisition and recall across the day. From a mechanistic perspective, the majority of studies have investigated mammalian hippocampal-dependent learning and memory, as this system is highly tractable. The hippocampus plays a major role in learning and memory, and has the potential to integrate circadian information in many ways, including information from local, independent oscillators, and through circadian modulation of neurogenesis, synaptic remodeling, intracellular cascades, and epigenetic regulation of gene expression. These local processes are combined with input from other oscillatory systems to synergistically augment hippocampal rhythmic function. This overview presents an account of the current state of knowledge on circadian interactions with learning and memory circuitry and provides a framework for those interested in further exploring these interactions.
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Many types of learning show circadian modulation.
“Many types of learning show circadian modulation49.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [49]
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- Authors
- Smarr, B. L., Jennings, K. J., Driscoll, J. R., & Kriegsfeld, L. J.
- Affiliations
- University of California System (US)
- Venue
- Behavioral Neuroscience
- Published
- 2014
- Volume
- 128
- Issue
- 3
- Pages
- 283-303
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC4385793
- OpenAlex
- W2119461571
- Cited by
- 166
- References
- 248
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 23 · 2021: 19 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 6
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01 HD050470)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian clock, learning, memory, hippocampus, circadian rhythm, memory consolidation, synaptic plasticity, epigenetic regulation, local oscillator, hippocampal-dependent memory
- MeSH terms
- Animals, Circadian Rhythm, Hippocampus, Learning, Memory, Synapses, Long-Term Potentiation, Epigenesis, Genetic, Neurogenesis, Circadian Rhythm Signaling Peptides and Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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