The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse
Abstract
The choroid plexus epithelium forms the blood-cerebrospinal fluid (CSF) barrier and is responsible for the secretion of the CSF from the blood. The morphological correlate of the blood-CSF barrier are the tight junctions of choroid plexus epithelium. By freeze-fracture electron microscopy it has been demonstrated that choroid plexus epithelial tight junctions form parallel strands resembling those of Sertoli cells building the blood-testis barrier and those of the myelin sheaths of oligodendrocytes. As the oligodendrocyte specific protein/claudin-11 has been shown to be the central mediator of parallel-array tight junctions in Sertoli cells and myelin sheaths in mice, we asked whether claudin-11 is present in the tight junctions of choroid plexus epithelial cells of the mouse. Here, we present the first direct evidence that claudin-11 besides claudin-1 and -2, occludin and the zonula occludens protein ZO-1 is present in choroid plexus epithelial tight junctions. During inflammation in the central nervous system such as experimental autoimmune encephalomyelitis, the molecular composition of choroid plexus epithelial tight junctions does not change considerably. Their unique molecular composition, with claudin-11 accompanied by claudin-1 and claudin-2 points to a unique regulatory mechanism of the blood-CSF-barrier function.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, ependymal cells overlying these vessels do have tight junctions and are tasked with forming a blood-CSF barrier composed of transmembrane proteins such as occludin, claudin-1, claudin-2, and claudin-11 (52, 53).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [53]
Citations
Cites
Furuse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.391 · Cited by 962
Morita, K., Sasaki, H., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.185 · Cited by 867
Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 712
CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice
Gow, A., Southwood, C. M., Li, J. S., Pariali, M., Riordan, G. P., Brodie, S. E., Danias, J., Bronstein, J. M., Kachar, B., & Lazzarini, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81553-6 · Cited by 702
Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands
Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.195 · Cited by 612
Occludin and claudins in tight-junction strands: leading or supporting players?
Tsukita, S., & Furuse, M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01578-0 · Cited by 592
Liebner, S., Fischmann, A., Rascher, G., Duffner, F., Grote, E.-H., Kalbacher, H., & Wolburg, H. (2000) · Acta Neuropathologica · doi:10.1007/s004010000180 · Cited by 490
Self-citationTsukita, S., & Furuse, M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.1.13 · Cited by 458
Mitic, L. L., Itallie, C. M. V., & Anderson, J. M. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.2.g250 · Cited by 452
Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis
Morita, K., Sasaki, H., Fujimoto, K., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.3.579 · Cited by 444
Cited by
Sorted by citations
Items 201–210 of 210
Current Advances in Drug Development, Design, and Strategies for Brain Tumors
Waghulde, S., Pawar, D., & Vaidhun, B. H. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898811716125010004
Senthil, S., Tagge, I., Fetco, D., Hsieh, C. H., Assemlal, H.-E., Karimaghaloo, Z., Fetco, E., Moore, G. R. W., Arnold, D. L., Rudko, D. A., et al. (2026) · Journal of Neuroimaging · doi:10.1111/jon.70132 · Cited by 4
Sluijters, O. J. J., Pooley, J. R., & Singleton, W. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00779-5
Gromadzki, B., Wiciński, M., Siedlecki, Z., Porzych, R., & Pisarski, I. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15166192
Claudin-2 in the Rat Hypothalamus in a Model of Chronic Kidney Disease
Piankov, А. А., Морина, И. Ю., & Romanova, I. V. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040071
Primary cell and tissue cultures of human choroid plexus epithelial cells
Bihlmaier, R., Scharr, M., Neckel, P. H., Hirt, B., & Mack, A. F. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1827493
Zheng, C., Ren, B., Wang, J., Guo, Q., Xie, Z., Li, S., Ye, D., Wang, H., & Zheng, W. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102542
Diffusion Barriers of the Lateral Ventricular System
Saravanakumar, A. (2012) · OpenCommons - UConn (University of Connecticut)
Metadata
- Authors
- Wolburg, H., Wolburg-Buchholz, K., Liebner, S., & Engelhardt, B.
- Affiliations
- University of Tübingen (DE)
- Max Planck Society (DE)
- Corresponding author
- Wolburg, Hartwig
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 307
- Issue
- 2
- Pages
- 77-80
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2031759209
- Cited by
- 210
- References
- 27
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 14 · 2021: 8 · 2020: 9 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 14 · 2012: 6
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- choroid plexus epithelium, tight junctions, claudin-1, claudin-2, claudin-11, blood-CSF barrier, occludin, ZO-1, experimental autoimmune encephalomyelitis, neuroinflammation, mice
- MeSH terms
- Animals, Blood-Brain Barrier, Cell Membrane Permeability, Choroid Plexus, Encephalomyelitis, Autoimmune, Experimental, Epithelium, Female, Immunohistochemistry, Membrane Proteins, Nerve Tissue Proteins, Phosphoproteins, Tight Junctions, Mice, Claudins, Claudin-1, Zonula Occludens-1 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
