Engelhardt, Britta

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology

Chemokine receptors and signalingMultiple Sclerosis Research Studies

Cited by 1,206

The movers and shapers in immune privilege of the CNS

Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 893

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

Engelhardt, B., & Ransohoff, R. M. (2012) · Trends in Immunology

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 686

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

Tietz, S., & Engelhardt, B. (2015) · Journal of Cell Biology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 551

Strategies to advance translational research into brain barriers

Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., et al. (2008) · The Lancet Neurology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 474

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease

Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B. (2018) · Acta Neuropathologica

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 436

Vascular, glial, and lymphatic immune gateways of the central nervous system

Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 362

Novel insights into the development and maintenance of the blood-brain barrier

Engelhardt, B., & Liebner, S. (2014) · Cell and Tissue Research

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 313

Immune cell trafficking across the blood-brain barrier in the absence and presence of neuroinflammation

Marchetti, L., & Engelhardt, B. (2020) · Vascular Biology

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 304

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood–Brain Barrier Endothelium

Steiner, O., Coisne, C., Cecchelli, R., Boscacci, R., Deutsch, U., Engelhardt, B., & Lyck, R. (2010) · The Journal of Immunology

Cell Adhesion Molecules ResearchBarrier Structure and Function Studies

Cited by 293

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

Lopes Pinheiro, M. A., Kooij, G., Mizee, M. R., Kamermans, A., Enzmann, G., Lyck, R., Schwaninger, M., Engelhardt, B., & de Vries, H. E. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 247

Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

Greenwood, J., Heasman, S. J., Alvarez, J. I., Prat, A., Lyck, R., & Engelhardt, B. (2011) · Neuropathology and Applied Neurobiology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 240

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

Enzmann, G., Mysiorek, C., Gorina, R., Cheng, Y.-J., Ghavampour, S., Hannocks, M.-J., Prinz, V., Dirnagl, U., Endres, M., Prinz, M., et al. (2013) · Acta Neuropathologica

Barrier Structure and Function StudiesAcute Ischemic Stroke Management

Cited by 225

Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse

Wolburg, H., Wolburg-Buchholz, K., Liebner, S., & Engelhardt, B. (2001) · Neuroscience Letters

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 210

The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.

Engelhardt, B., Laschinger, M., Schulz, M., Samulowitz, U., Vestweber, D., & Hoch, G. (1998) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesCell Adhesion Molecules Research

Cited by 203

Cell surface levels of endothelial ICAM‐1 influence the transcellular or paracellular T‐cell diapedesis across the blood–brain barrier

Abadier, M., Haghayegh Jahromi, N., Cardoso Alves, L., Boscacci, R., Vestweber, D., Barnum, S., Deutsch, U., Engelhardt, B., & Lyck, R. (2015) · European Journal of Immunology

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 200

Wiring the Vascular Network with Neural Cues: A CNS Perspective

Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B. (2015) · Neuron

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 178

Dysferlin Is a New Marker for Leaky Brain Blood Vessels in Multiple Sclerosis

Hochmeister, S., Grundtner, R., Bauer, J., Engelhardt, B., Lyck, R., Gordon, G., Korosec, T., Kutzelnigg, A., Berger, J. J., Bradl, M., et al. (2006) · Journal of Neuropathology and Experimental Neurology

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 160

Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

Pfeiffer, F., Schäfer, J., Lyck, R., Makrides, V., Brunner, S., Schaeren-Wiemers, N., Deutsch, U., & Engelhardt, B. (2011) · Acta Neuropathologica

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 160

Molecular anatomy of adult mouse leptomeninges

Pietilä, R., Del Gaudio, F., He, L., Vázquez-Liébanas, E., Vanlandewijck, M., Muhl, L., Mocci, G., Bjørnholm, K. D., Lindblad, C., Fletcher-Sandersjöö, A., et al. (2023) · Neuron

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 145

Ischemia–reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function

Enzmann, G., Kargaran, S., & Engelhardt, B. (2018) · Therapeutic Advances in Neurological Disorders

Neuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

Cited by 119

Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation

Steiner, O., Coisne, C., Engelhardt, B., & Lyck, R. (2011) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 94

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

Lyck, R., Lécuyer, M.-A., Abadier, M., Wyss, C. B., Matti, C., Rosito, M., Enzmann, G., Zeis, T., Michel, L., García Martín, A. B., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 75

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

Li, Z., Korhonen, E. A., Merlini, A., Strauss, J., Wihuri, E., Nurmi, H., Antila, S., Paech, J., Deutsch, U., Engelhardt, B., et al. (2020) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 52