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Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 mice
Abstract
Apolipoprotein E (apoE) genotype is well known as a risk factor for Alzheimer's disease, but more recently also has been associated with the incidence or disease progression of other neurological diseases including amyotrophic lateral sclerosis (ALS). In the present study we have examined the distribution of apoE in the spinal cord of transgenic mice with a familial ALS-linked superoxide dismutase 1 (G93A-SOD1) mutation. Western immunoblotting and immunocytochemistry showed a strong increase in apoE expression in G93A-SOD1 mice coincident with the onset of paralysis (age > 24 weeks). Increased apoE expression occurred in astrocytes and throughout the neuropil. The increase in apoE expression closely correlated in time and spatial distribution with axonal and neuronal degeneration as determined with a silver staining procedure, consistent with a role as an 'injury-response' protein.
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The observed statistical association supports continued evaluation of apoe as a potential injury-response protein in experimental studies of motor neuron degeneration.
“Our observed statistical association supports a continued evaluation of apoe as a potential “injury-response” protein in experimental studies of motor neuron degeneration (62).”
From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [62]
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Cites
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Cited by
Sorted by citations
Cholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500
Association of ALS with head injury, cigarette smoking and APOE genotypes
Schmidt, S., Kwee, L. C., Allen, K. D., & Oddone, E. Z. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.01.011 · Cited by 117
Metadata
- Authors
- Haasdijk, E. D., Vlug, A., Mulder, M. T., & Jaarsma, D.
- Affiliations
- Erasmus University Rotterdam (NL)
- Maastricht University (NL)
- Corresponding author
- Jaarsma, Dick
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 335
- Issue
- 1
- Pages
- 29-33
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2009538497
- Cited by
- 29
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- apolipoprotein E, amyotrophic lateral sclerosis, SOD1 G93A mice, spinal cord, neurodegeneration, astrocytes, axonal degeneration, injury response
- MeSH terms
- Amyotrophic Lateral Sclerosis, Animals, Apolipoproteins E, Astrocytes, Axons, Immunohistochemistry, Mice, Transgenic, Mutation, Nerve Degeneration, Neurons, Paralysis, Spinal Cord, Superoxide Dismutase, Blotting, Western, Neuropil, Mice
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