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A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve
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Astrocytes provide neurons with exogenous cholesterol in the form of apoE-containing high density lipoprotein (HDL)-like particles.
“astrocytes provide neurons with exogenous cholesterol in the form of apoE-containing high density lipoprotein (HDL)-like particles (Boyles et al., 1985, Boyles et al., 1989, Yu et al., 2010)”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Boyles et al., 1989
The Discussion (page unavailable) proposes that apoE- and apoA-I-containing lipoproteins may transfer cholesterol within an injured rat sciatic nerve, potentially to growing axons. It does not show that astrocytes provide neurons with cholesterol; it identifies macrophages as the major apoE producers in the injured nerve. (LLM, conf=0.86)
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Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829
Self-citationAstrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
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Research works printed but not linked: 7
- Skene, J. H. P., and E. M. Shooter. 1983. Denervated sheath cells secrete a new protein after nerve injury. Proc. Natl. Acad. Sci. USA. 80:4169-4173.
- Ignatius, M. J., P. J. Gebicke-Harter, J. H. P. Skene, J. W. Schilling, K. H. Weisgraber, R. W. Mahley, and E. M. Shooter. 1986. Expression of apolipoprotein E during nerve degeneration and regen- eration. Proc. Natl. Acad. Sci. USA. 83:1125-1129.
- Snipes, G. J., C. B. McGuire, J. J. Norden, and J. A. Freeman. 1986. Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc. Natl. Acad. Sci. USA. 83:1130-1134.
- Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
- Cajal, S. R. Y. 1928. Degeneration and Regeneration of the Nervous System. R. M. May, editor. Oxford University Press, London. 224-264.
- Basu, S. K., M. S. Brown, Y. K. Ho, R. J. Havel, and J. L. Goldstein. 1981. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc. Natl. Acad. Sci. USA. 78:7545- 7549.
- Weisgraber, K. H., and R. W. Mahley. 1983. Characterization of rat plasma lipoproteins. In CRC Handbook of Electrophoresis, Vol. IV: Lipoprotein Studies of Nonhuman Species. L. A. Lewis and H. K. Naito, editors. CRC Press, Boca Raton, FL. 103-132.
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Metadata
- Authors
- Boyles, J. K., Zoellner, C. D., Anderson, L. J., Kosik, L. M., Pitas, R. E., Weisgraber, K. H., Hui, D. Y., Mahley, R. W., Gebicke-Haerter, P. J., & Ignatius, M. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1989-03-01
- Volume
- 83
- Issue
- 3
- Pages
- 1015-1031
- ISSN
- 0021-9738
- Cited by
- 419
- References
- 2
- Language
- en
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