Macrophage colony stimulating factor promotes phagocytosis by murine microglia
Abstract
Macrophage colony stimulating factor (M-CSF) and its receptor are upregulated in the brain in Alzheimer's disease. M-CSF induces activation and proliferation of microglial cells and expression of proinflammatory cytokines. Amyloid beta (Abeta) immunization experiments suggest that microglia have the capacity to aggressively clear Abeta from the brain under certain circumstances. We examined the role of M-CSF in phagocytosis of fluorescent microspheres and Abeta by cultured microglia. M-CSF treatment increased microglial cell phagocytosis of both microspheres and of Abeta. Antibody neutralization of M-CSF inhibited Abeta uptake induced by overexpression of the M-CSF receptor on microglia. These results suggest that M-CSF could be important in promoting microglial clearance of abnormal protein aggregates such as Abeta.
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CSF-1 mediates microglial-induced neurotoxicity by promoting the release of inflammatory cytokines.
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From Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice (2020) · cites this paper as [35]
CSF-1 stimulates clearance of Aβ.
“stimulates clearance of A 𝛃 (35)”
From Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice (2020) · cites this paper as [35]
CSF-1 increases microglial phagocytic activity.
“It has been shown that CSF-1 increases microglial phagocytic activity”
From Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice (2020) · cites this paper as [35]
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Self-citation
- Authors
- Mitrasinovic, O. M., Vincent, V. A. M., Simsek, D., & Murphy, G. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Murphy, Greer M
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 344
- Issue
- 3
- Pages
- 185-188
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2094812747
- Cited by
- 45
- References
- 20
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2016: 3 · 2015: 2 · 2013: 3 · 2012: 3
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- macrophage colony-stimulating factor, microglia, phagocytosis, amyloid-beta, Alzheimer's disease, M-CSF receptor, microglial activation, protein aggregate clearance, fluorescent microspheres
- MeSH terms
- Animals, Cell Line, Flow Cytometry, Fluorescent Dyes, Microspheres, Peptide Fragments, Phagocytosis, Macrophage Colony-Stimulating Factor, Amyloid beta-Peptides, Microglia, Mice
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